DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Sos

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_476597.2	Gene:	Sos / 34790	FlyBaseID:	FBgn0001965	Length:	1596	Species:	Drosophila melanogaster

Alignment Length:	669	Identity:	139/669 - (20%)
Similarity:	230/669 - (34%)	Gaps:	170/669 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   196 SQSGSLDENSDITIEN----GTEDIDDYIEDSLSNMCDST-IDNDAEDAGVETPLLSD-CQGSHV 254
            |.|||......|.|..    |.:|.|.|         |.| .:|.|...|:.||.|.. .:..|.
  Fly    31 SGSGSQGGGGGIGIGGGGVAGLQDCDGY---------DFTKCENAARWRGLFTPSLKKVLEQVHP 86

  Fly   255 RELSFDLALDVVSSTTDG--ASNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSS 317
            |..:.:.||..|......  |.....|.|.| .:..:..:..:.|: |:..........::::..
  Fly    87 RVTAKEDALLYVEKLCLRLLAMLCAKPLPHS-VQDVEEKVNKSFPA-PIDQWALNEAKEVINSKK 149

  Fly   318 SSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTD 382
            ..|.|...:...|.:.....|...||:::.........|.|..|:..|  ||...|..  |:|.:
  Fly   150 RKSVLPTEKVHTLLQKDVLQYKIDSSVSAFLVAVLEYISADILKMAGD--YVIKIAHC--EITKE 210

  Fly   383 NIA----CNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVL 443
            :|.    .:....|..|..|..:.....:|    .:|.||:| :|:   .::|||..|..|...|
  Fly   211 DIEVVMNADRVLMDMLNQSEAHILPSPLSL----PAQRASAT-YEE---TVKELIHDEKQYQRDL 267

  Fly   444 TALKTKFMGPLERHLNQD-ELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPF 507
            ..:...|...|.:.::.. ||..||..|.::.::....|..|.:.:..:.:.....|...|.|
  Fly   268 HMIIRVFREELVKIVSDPRELEPIFSNIMDIYEVTVTLLGSLEDVIEMSQEQSAPCVGSCFEE-- 330

  Fly   508 LIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVP-----------MQ 561
                     |..|.::  ||.||...  .:..:..||      .|.::||.|           .:
  Fly   331 ---------LAEAEEF--DVYKKYAY--DVTSQASRD------ALNNLLSKPGASSLTTAGHGFR 376

  Fly   562 RILKYH---LLL------------DKLVKETSPLHDDYRSLER-------------------AKE 592
            ..:||:   |||            .|.:|:.|...||..|.|:                   :||
  Fly   377 DAVKYYLPKLLLVPICHAFVYFDYIKHLKDLSSSQDDIESFEQVQGLLHPLHCDLEKVMASLSKE 441

  Fly   593 AMIDVSQYINEVKRDSDHLVIIQKVKDSICDI-HLLQNGNGSDLLQYGRLLLDGELHIKAHEDQK 656
            ..:.||   ..|:|.    :.|::.::....: |......|.:..::.|            ||..
  Fly   442 RQVPVS---GRVRRQ----LAIERTRELQMKVEHWEDKDVGQNCNEFIR------------EDSL 487

  Fly   657 TKL---------RYAFVFDKILIMVKALHIK----TGDMQYTYRDSHNLADYRVEQSHSRRTIGR 708
            :||         |..|:||.::::.||...|    .|...|         |||:::.:..|.:..
  Fly   488 SKLGSGKRIWSERKVFLFDGLMVLCKANTKKQTPSAGATAY---------DYRLKEKYFMRRVDI 543

  Fly   709 DTR-----FKYQLLLARKSGKTAFTLYLKSEHERDKW---------RKALTEAMESLEPPGCQST 759
            :.|     .|....||.:...........::|:.| |         :..|...::|:    .|..
  Fly   544 NDRPDSDDLKNSFELAPRMQPPIVLTAKNAQHKHD-WMADLLMVITKSMLDRHLDSI----LQDI 603

  Fly   760 DHK-------MEIYTFDAP 771
            :.|       .|||.|..|
  Fly   604 ERKHPLRMPSPEIYKFAVP 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	46/220 (21%)
		PH_Vav	624..753	CDD:269930	29/156 (19%)
		PH	641..749	CDD:278594	25/134 (19%)
		C1_1	761..804	CDD:278556	6/18 (33%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Sos	NP_476597.2	Histone	90..216	CDD:278551	25/131 (19%)
		H2A	155..>196	CDD:305064	7/40 (18%)
		RhoGEF	249..432	CDD:238091	43/206 (21%)
		PH_SOS	476..586	CDD:269963	25/131 (19%)
		PH	482..587	CDD:278594	25/126 (20%)
		RasGEFN	637..791	CDD:214571
		RasGEF	825..1062	CDD:238087
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I8515
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910