DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and ccdc28a

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_005158777.1	Gene:	ccdc28a / 326808	ZFINID:	ZDB-GENE-030131-5007	Length:	209	Species:	Danio rerio

Alignment Length:	313	Identity:	53/313 - (16%)
Similarity:	94/313 - (30%)	Gaps:	133/313 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 LDVVSSTTDGASNAVTPTPE---------SYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSS 318
            :.|:..|.:|.|    |.|:         |..|:|..|.:...|       |..|..:..|.|..
Zfish     9 VQVLPPTPEGQS----PVPDNLNDTMEEKSKKRKSPKPSSNQLP-------PSVPARKTTSRSFG 62

  Fly   319 SSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDN 383
            ...:....|||.:....|                                   :.|.:|:
Zfish    63 VGGIGTHSSQRAKNRRGA-----------------------------------RDKPRPQ----- 87

  Fly   384 IACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKT 448
                                        |:|..::.:|..|..: :.::.|.:.....:|:.|..
Zfish    88 ----------------------------SQSGKSNQSSHIQHSF-LTDVSDVQEMEKGLLSLLND 123

  Fly   449 KFMGPLERHLNQ---DELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIY 510
            ...|.|:...|:   |::.    .:||           ::|:|.              |..|.:|
Zfish   124 FHSGKLQAFGNECSIDQME----HVRE-----------MQETLA--------------RLHFDLY 159

  Fly   511 GEFCSLLLGAIDYLADVCKKNQI---IDQLVQKCER-DYNVGKLQLRDILSVP 559
            ||        :|.|.:..:|:..   :|:|:...|. ..::.||.|.|...||
Zfish   160 GE--------VDELPEDQRKSAYDTNMDKLLLNLEELSSSIQKLNLADTQDVP 204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	28/139 (20%)
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
ccdc28a	XP_005158777.1	DUF4061	108..180	CDD:290010	19/108 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910