DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and plekhg4

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_009301619.1	Gene:	plekhg4 / 326099	ZFINID:	ZDB-GENE-030131-4824	Length:	2630	Species:	Danio rerio

Alignment Length:	947	Identity:	177/947 - (18%)
Similarity:	329/947 - (34%)	Gaps:	251/947 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 AEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDAD 109
            ||:::..:.:|      :..:||       |:|:::.:..:....|.::|:             :
Zfish  1778 AELQVYEVKVR------SFWVHL-------RDFSQRVEDTKDKIDKTVQLY-------------E 1816

  Fly   110 LFEPTMLYDLTNF-HRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLH---S 170
            .|:....:.|... |...:::.......|.|.:...|..:..|..|...:|..|  .|||.   .
Zfish  1817 FFDKAYEWALEGMRHLACVSMEDCGMSEKCQSVITCLETYRSQHPPIPDAHFQE--MKDLAGELK 1879

  Fly   171 TDLNMRK---------------TSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTEDIDDYI 220
            ::..:::               ...::.:..|..:...::.:|.|...|||::.::...
Zfish  1880 SEQGLKQWKFAWSKCQETKQMFEKKLEMALRSRRDSDSKSVRSDSSRRNSDVSTKHQER------ 1938

  Fly   221 EDSLSNMC----------------DSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSST 269
            ..|:|..|                .||....:..:|:.
Zfish  1939 SSSISFSCRKAFGGAWGRDRLSSHSSTSSTPSSPSGIR--------------------------- 1976

  Fly   270 TDGASNAVTPTPESYARQSQSPLAA------AAPSVPVSAAPGPPMGR-LVSTSSSSSSLLVSES 327
            .|......|||...|:.:.:.|.:.      ...|:....:|..|... |.|||.|.:|:
Zfish  1977 LDARDTVRTPTGSPYSIEHRIPHSTPVRSHRLTRSISTDESPQSPHAEGLASTSPSGTSV----- 2036

  Fly   328 QRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYD 392
            |..:|......::.::.:....:|.             .|..|....|:...|  .:...|....
Zfish  2037 QTNRRVLRKTQSFDTAGSEPVSQYG-------------TCQRTLSEPARRGNT--GVFIKGLEVS 2086

  Fly   393 HTNTKEEEVYQDLCALHRTSR--SQTASSTSFEQRD------YVIRELIDTESNYLDVLTALKTK 449
            .|...:......|..:|..|.  :..:.|.:.|.|.      :::.|::.||..|:..|..:...
Zfish  2087 STEVIDRPYSPRLPPIHGWSSIDAHRSGSPAPETRSKGSKLRHIVDEMVTTEREYVRSLRYIIDN 2151

  Fly   450 FMGPLERHLNQDELR----LIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIY 510
            :...:||.:...:||    :||..:.:|||.|:::..|..||.. |..::::..||..::.|.:|
Zfish  2152 YFPEMERAVLPQDLRGKRSVIFGNLEKLVDFHSQYFLKELESCC-NHPLRVSHCFLRHQDQFSLY 2215

  Fly   511 GEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDY------NVG-KLQLRDILSVPMQRILKYHL 568
            ..:              .|.....|.|:.....::      .:| |:.|...|..|:||:.||.|
Zfish  2216 ALY--------------SKNKPKSDTLLASHGNNFFKHKQMELGDKMDLASYLLKPIQRMSKYAL 2266

  Fly   569 LLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNG--- 630
            ||..|:||.|.:.:...:..||...|:...      .|..:.|:.:..::|  ||::|.:.|
Zfish  2267 LLKDLIKEVSEVQEQELTYLRAAAEMVKFQ------LRHGNDLLAMDAIRD--CDVNLKEQGQLV 2323

  Fly   631 -NGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLAD 694
             .....:.|||               |...|:.|:|:.:::..|...|:.|...|.|:.|...||
Zfish  2324 RQDEFTISYGR---------------KKCQRHVFLFEDLVLFSKPKRIEGGLDVYIYKHSFKTAD 2373

  Fly   695 YRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKS-----EH------ERDKWRKALTEAM 748
            ..:.::....::      ::::...|::.|.. |..|:|     :|      .|..|::|.....
Zfish  2374 VGMTETSGENSL------RFEIWFRRRTSKNQ-TYILQSSTADIKHAWTCDIARILWQQATRNKE 2431

  Fly   749 ESLEPPGCQSTDHK--MEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQ 811
            ..::........:|  ::|...||....|.....:|||   |.|.:.   |:.......:...|:
Zfish  2432 IRMQEMVSMGVGNKPFLDIKPSDAAINDRAIDYIMKGR---GARTRA---SIAVSLFDHSNPFKR 2490

  Fly   812 ----NPVSVPP----PVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQ-GP-----S 862
                .|||..|    |.....|...|           .|...::.:   |...||. ||     .
Zfish  2491 AAVNTPVSGTPVSGGPSSSTLLGPLN-----------LHMYSSQSL---LAGERPLIGPCIEEDE 2541

  Fly   863 TAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLS 899
            ..|||....|:.|            |:||.|. :|||
Zfish  2542 LEHETSSQPSMTT------------ESSGSSS-HCLS 2565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	12/87 (14%)
		RhoGEF	428..603	CDD:279015	45/185 (24%)
		PH_Vav	624..753	CDD:269930	26/143 (18%)
		PH	641..749	CDD:278594	21/118 (18%)
		C1_1	761..804	CDD:278556	11/44 (25%)
		SH2_Vav_family	824..934	CDD:198193	20/82 (24%)
		SH3	940..993	CDD:302595
plekhg4	XP_009301619.1	COG5099	467..>912	CDD:227430
		SEC14	1433..1573	CDD:238099
		BAR	<1707..>1807	CDD:299863	7/41 (17%)
		RhoGEF	2130..2302	CDD:279015	46/192 (24%)
		PH_puratrophin-1	2294..2430	CDD:270062	31/165 (19%)
		PH	2319..2414	CDD:278594	22/116 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910