DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Vav and hwt

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_001259484.1 Gene:hwt / 32202 FlyBaseID:FBgn0264542 Length:1768 Species:Drosophila melanogaster


Alignment Length:523 Identity:109/523 - (20%)
Similarity:175/523 - (33%) Gaps:140/523 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   187 SSAEYYDRTSQSGSLDENSDITIE--NGTEDIDDYIEDSLSNMCDSTIDNDAEDAG---VETPLL 246
            ||.|....:|..||::.....|.|  ..|...:.....|||:....:....:..:|   |..|| 
  Fly  1289 SSTESIATSSSGGSMESLRSSTSEGNRSTSSSESRHSSSLSSHSSESGSGGSGGSGGSSVAYPL- 1352

  Fly   247 SDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTPESYARQSQSP---LAAAAPSVPVSAAPGPP 308
                  ....|.....|.::|..:|.:|.  .|...|.:.|||.|   ||..|.....|...|.|
  Fly  1353 ------RPAPLLLHSKLHILSPISDKSSQ--EPASASASEQSQQPSQQLAPMASQEDDSTTSGAP 1409

  Fly   309 MGRLVSTSSSSSSLLVSESQRLQRAA--AAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTF 371
            .|..|..::|      .:..|..|.|  .|:......:..::...: ::|.:|.|...    :..
  Fly  1410 AGNQVQVNAS------LKQPRSNRGAPNKALLQLADELLGSDSGIS-LHSREDGKPQA----LAL 1463

  Fly   372 QAKAKP-------EVTTDNIACNGTGYDHTN----------------TKEEEVYQDLCAL----- 408
            |....|       |.||.:...:|.|.....                :....:.|||..|     
  Fly  1464 QRLTLPKLQLIGAEGTTTSATASGAGGSSATGGSSGAGGSGSGSVVASGSTGIQQDLRDLPFDMP 1528

  Fly   409 ---HRTSRSQTASSTSFEQRDYVIREL-IDTESNYLDVLTALKTKFMGPLERHL--NQDELRLIF 467
               .|.:..|.|:.||.......:.|| .|                |..|.|.|  ||.|:..:.
  Fly  1529 KLRRRKTLQQEAACTSGSATSVDLGELPFD----------------MPKLRRRLRANQAEINNLL 1577

  Fly   468 PRIRELVDI-HTKFLDKLRESLTPNAKVKMA----QVFLDFREPFLIYGEFCSLLLGAIDYLADV 527
            ....|...| .......:|:....::|:..|    .:.|:..|......:|.||.|..::     
  Fly  1578 MHSTESSGISQASSSHSMRDDQKMSSKLDTALFRQNLTLNLNESRQATKQFGSLDLRGLN----- 1637

  Fly   528 CKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETS--PLHD-------- 582
              .|:   :|.....:.| |..:.|.|: ::|::|...||..:.::..||:  ||.:        
  Fly  1638 --SNK---ELNMNLSQGY-VTAVDLIDV-TIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNC 1695

  Fly   583 -----DYR-SLERAKEAM------IDVSQYI--------------------NEVK-RDSDHLVII 614
                 ||. ||:.||..|      .:..|||                    |.:. |.::|:.:|
  Fly  1696 ESTKQDYSLSLKGAKGFMHMRIQRNETGQYILGQFSRPFETVPEMIRHFCLNRLPVRGAEHMCLI 1760

  Fly   615 QKV 617
            :.|
  Fly  1761 EPV 1763

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015 45/224 (20%)
PH_Vav 624..753 CDD:269930
PH 641..749 CDD:278594
C1_1 761..804 CDD:278556
SH2_Vav_family 824..934 CDD:198193
SH3 940..993 CDD:302595
hwtNP_001259484.1 SH2_SHB_SHD_SHE_SHF_like 1666..1763 CDD:198198 20/96 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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