DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and hwt

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001259484.1	Gene:	hwt / 32202	FlyBaseID:	FBgn0264542	Length:	1768	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	109/523 - (20%)
Similarity:	175/523 - (33%)	Gaps:	140/523 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 SSAEYYDRTSQSGSLDENSDITIE--NGTEDIDDYIEDSLSNMCDSTIDNDAEDAG---VETPLL 246
            ||.|....:|..||::.....|.|  ..|...:.....|||:....:....:..:|   |..||
  Fly  1289 SSTESIATSSSGGSMESLRSSTSEGNRSTSSSESRHSSSLSSHSSESGSGGSGGSGGSSVAYPL- 1352

  Fly   247 SDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTPESYARQSQSP---LAAAAPSVPVSAAPGPP 308
                  ....|.....|.::|..:|.:|.  .|...|.:.|||.|   ||..|.....|...|.|
  Fly  1353 ------RPAPLLLHSKLHILSPISDKSSQ--EPASASASEQSQQPSQQLAPMASQEDDSTTSGAP 1409

  Fly   309 MGRLVSTSSSSSSLLVSESQRLQRAA--AAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTF 371
            .|..|..::|      .:..|..|.|  .|:......:..::...: ::|.:|.|...    :..
  Fly  1410 AGNQVQVNAS------LKQPRSNRGAPNKALLQLADELLGSDSGIS-LHSREDGKPQA----LAL 1463

  Fly   372 QAKAKP-------EVTTDNIACNGTGYDHTN----------------TKEEEVYQDLCAL----- 408
            |....|       |.||.:...:|.|.....                :....:.|||..|
  Fly  1464 QRLTLPKLQLIGAEGTTTSATASGAGGSSATGGSSGAGGSGSGSVVASGSTGIQQDLRDLPFDMP 1528

  Fly   409 ---HRTSRSQTASSTSFEQRDYVIREL-IDTESNYLDVLTALKTKFMGPLERHL--NQDELRLIF 467
               .|.:..|.|:.||.......:.|| .|                |..|.|.|  ||.|:..:.
  Fly  1529 KLRRRKTLQQEAACTSGSATSVDLGELPFD----------------MPKLRRRLRANQAEINNLL 1577

  Fly   468 PRIRELVDI-HTKFLDKLRESLTPNAKVKMA----QVFLDFREPFLIYGEFCSLLLGAIDYLADV 527
            ....|...| .......:|:....::|:..|    .:.|:..|......:|.||.|..::
  Fly  1578 MHSTESSGISQASSSHSMRDDQKMSSKLDTALFRQNLTLNLNESRQATKQFGSLDLRGLN----- 1637

  Fly   528 CKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETS--PLHD-------- 582
              .|:   :|.....:.| |..:.|.|: ::|::|...||..:.::..||:  ||.:
  Fly  1638 --SNK---ELNMNLSQGY-VTAVDLIDV-TIPLERQGWYHGAITRIEAETTLRPLSEGSFLVRNC 1695

  Fly   583 -----DYR-SLERAKEAM------IDVSQYI--------------------NEVK-RDSDHLVII 614
                 ||. ||:.||..|      .:..|||                    |.:. |.::|:.:|
  Fly  1696 ESTKQDYSLSLKGAKGFMHMRIQRNETGQYILGQFSRPFETVPEMIRHFCLNRLPVRGAEHMCLI 1760

  Fly   615 QKV 617
            :.|
  Fly  1761 EPV 1763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	45/224 (20%)
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
hwt	NP_001259484.1	SH2_SHB_SHD_SHE_SHF_like	1666..1763	CDD:198198	20/96 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910