DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and quo

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001004109.2	Gene:	quo / 321031	ZFINID:	ZDB-GENE-030131-9944	Length:	1987	Species:	Danio rerio

Alignment Length:	744	Identity:	163/744 - (21%)
Similarity:	278/744 - (37%)	Gaps:	187/744 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 SQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQ 197
            :|||.::|...::    ||.:.|.:...|||        .||           ..|.:..:|.::
Zfish  1199 TQCRDIRQRLSEI----LQAAHTHKDSQDEA--------QLN-----------PVSGQTQNRAAE 1240

  Fly   198 SGSLDENSDITIENGTE--DIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFD 260
            .|   :|..:|.....|  ..:..:..|:.....|.|....|....||        .|:.|....
Zfish  1241 QG---DNETLTYLQSAEGSKFEQVMTSSVHEQSASRIQQSVECTEQET--------RHLHETKDK 1294

  Fly   261 L--ALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLL 323
            |  |..:.:.:|..|..:|..|.:..:...::...:..||:...:|  ..:...|..:..::|.|
Zfish  1295 LHNASSMHNESTSHAQQSVQCTVQKASMLQETNNTSRNPSMHKDSA--SHIQESVQCTDQNTSHL 1357

  Fly   324 VSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDD-------EKVYEDLCYVTFQAKAK----- 376
             .|.|       |:.::.|.....||.:.:.:|:||       .|..:...|..|.....
Zfish  1358 -HEPQ-------AISHHPSDRKLKEHHHKHSHSDDDLRKSGRIHKFGQTAHYKVFIRSQSAESCL 1414

  Fly   377 -------PEVTTDNIA----------------------------------C----NGTGY---DH 393
                   |...||..|                                  |    :|:|.   |:
Zfish  1415 RGYRYNIPLCKTDAAASCVGASLEGLSSELNQHDSFCSSASGFSQKCSSDCGSEDHGSGVRCSDN 1479

  Fly   394 TNTKEEE-VYQDLCALHRTSRSQTASSTSFE-QRDYVIRELIDTESNYLDVLTALKTKFMGPLER 456
            ..||:|| |.:..|.|..|       ||:.: ||  :::||:.||..|:..|..:...:|..|||
Zfish  1480 AFTKQEESVCKPECILENT-------STALKLQR--IMQELLQTEQEYVRALAYVVENYMPELER 1535

  Fly   457 HLNQDELR----LIFPRIRELVDIHT-KFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFC-- 514
            .....:||    |||..:.:|.|.|. .|:.:|  .|.......:.:.||..:|.|.:|..:.
Zfish  1536 PDVPQDLRGQRGLIFGNLEKLRDFHQHHFIQEL--ELCLEKPFSVGRCFLKHKESFGLYALYSKN 1598

  Fly   515 -----SLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLV 574
                 :||   |.:..|..|:.|   ||::..        |.|...|..|:|||.||.|||..|:
Zfish  1599 KPRSENLL---IQHGKDFFKQKQ---QLLKDA--------LDLSSYLLKPVQRISKYSLLLQDLL 1649

  Fly   575 KETSPLHDDYRSLERAK-EAMIDVSQYINEVKRDSDHLVIIQKVKDSI--CDIHLLQNGNGSDLL 636
            :|...:.:  ..|:|.: ...:::.|:  :::..::.|.:     |.|  ||::|.:.|   .|:
Zfish  1650 RECECVTN--AELQRTEIHTALNIIQF--QLRHGNNLLAM-----DDIYGCDVNLKEQG---QLI 1702

  Fly   637 QYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSH 701
            :....||...        :|...|:.|:|..:::..|......|:..|.|:.|...:|  :..:|
Zfish  1703 RQDEFLLTFR--------KKKCYRHIFLFQDLILFSKTRKTDVGNDTYIYKQSFKTSD--IGMTH 1757

  Fly   702 SRRTIG---------RDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQ 757
            :....|         |.|:..|.|..|.:..|.::|..|    ||..|.:|:......::.....
Zfish  1758 NSGDSGLCFEIWFRRRKTQDTYVLQAASREVKESWTRDL----ERILWEQAIHNREIRMQERVFM 1818

  Fly   758 STDHK--MEIYTFDAPTTCRHCSKFLKGR 784
            ...||  |:|...:...:.|..:..|.||
Zfish  1819 GIGHKPFMDIKPSEMAISDRAINCVLTGR 1847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	51/187 (27%)
		PH_Vav	624..753	CDD:269930	29/137 (21%)
		PH	641..749	CDD:278594	26/116 (22%)
		C1_1	761..804	CDD:278556	8/26 (31%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
quo	NP_001004109.2	SMC_N	<894..>1314	CDD:330553	30/148 (20%)
		RhoGEF	1507..1680	CDD:306973	51/192 (27%)
		PH_puratrophin-1	1673..1808	CDD:270062	35/158 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910