DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Vav and Mcf2

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:XP_008771798.1 Gene:Mcf2 / 317598 RGDID:1566098 Length:1110 Species:Rattus norvegicus


Alignment Length:435 Identity:93/435 - (21%)
Similarity:179/435 - (41%) Gaps:110/435 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   328 QRLQRAAAAVYNYRSSMASTEH---EYAY-----IYSEDDEKVYEDLCYVTFQAKAKPEVTTDNI 384
            ||:..|..:|...|:...|.:|   .|::     |:|    ||.:....:..|:..|.:.|.|:.
  Rat   607 QRMIPAPESVMRARTIFFSPKHVGIGYSFFQACKIFS----KVKKSWRQIQAQSNVKVQATQDSQ 667

  Fly   385 ACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYL----DVLTA 445
            ..|   :|.....:..:  |:.                  :::|:.|||.||..|:    .||..
  Rat   668 EKN---FDQPPKLDSSL--DIL------------------KNHVLNELIQTERAYVRELFTVLLG 709

  Fly   446 LKTKFMGP----LERHLNQDELRLIFPRIRELVDIHTK-FLDKLRESLTPNAKVKMAQVFLDFRE 505
            .:::...|    |...|.:::..::|..:.|:.:.|.. |:.:|.:  ..:|..::...||:.:|
  Rat   710 YRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSRLED--CSDAPERVGPCFLERKE 772

  Fly   506 PFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLV----------QKCERDYNVGKLQLRDILSVPM 560
            .|.:|.::|               :|:...:|:          |:|:|... .:|.|...|..|:
  Rat   773 DFQMYAKYC---------------QNKPRSELIWRKYSECAFFQECQRKLK-HRLGLDSYLLKPV 821

  Fly   561 QRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIH 625
            |||.||.|||.:|:| .|...:....|:.|.::|:::.:.:|    ||.|...|           
  Rat   822 QRITKYQLLLKELLK-YSKEGEGTTKLKEALDSMLELLKSVN----DSMHQTAI----------- 870

  Fly   626 LLQNGNGSDLLQYGRLLLDGELHI-KAHEDQKTKL----------RYAFVFDKILIMVKALHIKT 679
               ||...::...|:::|.|...: ..|....||:          |:.|:::|.::..|. ..::
  Rat   871 ---NGYVGNMNDLGKMILQGAFSVWVGHRKGATKMKDFARFKPMQRHLFLYEKAVMFCKR-RFES 931

  Fly   680 G---DMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARK 721
            |   |...:|...|.|   ::|::.....:..|.| |:::....|
  Rat   932 GEGADRYPSYSFKHCL---KMEEAGITEHVKGDNR-KFEIWYGEK 972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015 47/193 (24%)
PH_Vav 624..753 CDD:269930 22/112 (20%)
PH 641..749 CDD:278594 19/95 (20%)
C1_1 761..804 CDD:278556
SH2_Vav_family 824..934 CDD:198193
SH3 940..993 CDD:302595
Mcf2XP_008771798.1 SEC14 119..259 CDD:214706
SPEC 399..590 CDD:295325
RhoGEF 685..862 CDD:238091 47/195 (24%)
PH-like 869..1000 CDD:302622 23/123 (19%)
PH 884..997 CDD:278594 19/94 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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