Protein Alignment Vav and Arhgef25

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_001387885.1
• Gene: Arhgef25 / 314904
• RGDID: 735210
• Length: 613
• Species: Rattus norvegicus
• Alignment Length: 589
• Identity: 132/589 - (22%)
• Similarity: 229/589 - (38%)
• Gaps: 109/589 - (18%)

  Fly   276 AVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNY 340
            |..|.||||:      :|.:..|:..||..|     |.:.|..||.|  |...........|...
  Rat    66 AWAPQPESYS------IAGSEGSMSASAVSG-----LAALSGPSSGL--SSHPCSPVPPGPVTGL 117

  Fly   341 RSSMASTEHEYAYIYSEDD-------EKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKE 398
            |..:..::|..: :.:|.|       |....:....|.|  ..||:|.......|.|......:|
  Rat   118 RRWLDHSKHCLS-VETEADSGQTRQCENWMLEPTLTTGQ--ELPELTLLTTLLEGPGVKAQPAEE 179

  Fly   399 EEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDEL 463
            |.:.|      .....:....|:.|:..:|:.||::||..|:|.|..:...:|..:......:.|
  Rat   180 ETLSQ------APKNEEEQKKTALERSMFVLSELVETERMYVDDLGQIVEGYMATMATQGVPESL 238

  Fly   464 ----RLIFPRIRELVDIHTK-FLDKLRESL-TPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAID 522
                |::|..|:::.:.|.. ||.:|::.| .|:   .:||:|:.......:|..:|.....:..
  Rat   239 RGRDRIVFGNIQQIYEWHRDYFLQELQQCLKDPD---WLAQLFIKHERRLHMYVVYCQNKPKSEH 300

  Fly   523 YLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSL 587
            .|::.  .:...::|.|:...     :|||.|:|..|:|||:||.|||...:|.......|...|
  Rat   301 VLSEF--GDSYFEELRQQLGH-----RLQLSDLLIKPVQRIMKYQLLLKDFLKYYRRAGMDTEEL 358

  Fly   588 ERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAH 652
            |:|.|.|..|.:..|:       ::.:.:::           |....|...|:||......:...
  Rat   359 EQAVEVMCFVPKRCND-------MMSLGRLR-----------GFEGKLTAQGKLLGQDTFLVTEP 405

  Fly   653 E-----DQKTKLRYAFVFDKILIMVKAL------HIKTGDMQYTYRDSHNLADYRVEQSHSRRTI 706
            |     ..:.:.|..|:|::|:|..:||      ..:.|   |.|::|..::...:|.:..
  Rat   406 EAGGLLSSRGRERRVFLFEQIVIFSEALGGGGRGGTQPG---YVYKNSIKVSCLGLEGNLQ---- 463

  Fly   707 GRDTRFKYQLLLAR--KSGKTAFTLYLKSEHERDKWRKALTEAMES-------LEPPGCQSTDHK 762
            |...||   .|.:|  :.|...:.|..........|.|.:.:.:||       |:.|
  Rat   464 GNACRF---ALTSRGPEGGIQRYVLQASDPAVSQAWIKQVAQILESQRDFLNALQSP-------- 517

  Fly   763 MEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVH---KGCISSTGRCKQNPV-SVPPPVCDR 823
            :|....::.|.    |....|....|...::.|:|:|   .|.:.|.....:..| ..|.|:..:
  Rat   518 IEYQRRESQTN----SLGRSGGPGVGSPGRMAQVSMHTPINGSLPSLLLLPRGEVPRAPLPLDTQ 578

  Fly   824 QLSE 827
            .|||
  Rat   579 ALSE 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050
		RhoGEF	428..602	CDD:459876	49/179 (27%)
		PH_Vav	624..753	CDD:269930	30/148 (20%)
		C1_VAV	759..810	CDD:410360	10/53 (19%)
		SH2_Vav_family	824..934	CDD:198193	3/4 (75%)
		SH3	940..993	CDD:473055
Arhgef25	NP_001387885.1	RhoGEF	203..373	CDD:459876	49/179 (27%)
		PH2_Kalirin_Trio_p63RhoGEF	378..520	CDD:270061	31/170 (18%)