DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Plekhg5

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_038965663.1	Gene:	Plekhg5 / 310999	RGDID:	1303132	Length:	1101	Species:	Rattus norvegicus

Alignment Length:	684	Identity:	153/684 - (22%)
Similarity:	246/684 - (35%)	Gaps:	190/684 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 IYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIEDSLSNMC 228
            ||.|..:|.|      |:...|.....:|.|...... ||..   :|.|.:|     ..|||...
  Rat   218 IYLDQSNTPL------SLTFEAYRFGGHYLRVKAKPG-DEGK---VEQGVKD-----SKSLSLPA 267

  Fly   229 DSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTPESYARQSQSPLA 293
                   ...:|..||:|........||.|.|:               :.|   ...|::.|...
  Rat   268 -------LRPSGAGTPVLERVDPQSRRESSLDI---------------LAP---GRRRKNMSEFL 307

  Fly   294 AAAPSVPVSAAPGP-----PMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAY 353
            ... |:|...:|.|     |:|..|.:|.||.|.       ..|||:....:.||..||.
  Rat   308 GDT-SIPGQESPAPSSCSLPVGSSVGSSGSSESW-------KNRAASRFSGFFSSSPSTG----- 359

  Fly   354 IYSEDDEKVYEDL-----CYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEE------------- 400
            .:..:.:|: |.|     .|..|.....|         ....:||.:.:|||
  Rat   360 AFGREVDKM-EQLESKLHAYSLFGLPRMP---------RRLRFDHDSWEEEEDDEEEEDNSGLRL 414

  Fly   401 --VYQDLCALH-RTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDE 462
              .:::|...| :.:|.|.       .:...:.||:.||.:|:..|..:...|:..|   ||..|
  Rat   415 EDSWRELIDGHEKLTRRQC-------HQQEAVWELLHTEVSYIRKLRVITNLFLCCL---LNLQE 469

  Fly   463 LRL--------IFPRIRELVDIH--------TKFLDKLRES---LTPNAKVKMAQVFLDFREPFL 508
            ..|        :|..|.||..:|        ...|:|.|.:   |.|:..:|..::|....:|::
  Rat   470 SGLLCEVEAERLFSNIPELARLHRGLWSSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYI 534

  Fly   509 IYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKL 573
            .|   |....|.::|:..:.:.|.:....|...|:.....:|:|.|:|:.|.||:.||.|||..:
  Rat   535 RY---CMEEEGCMEYMRSLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKPHQRLTKYPLLLKSV 596

  Fly   574 VKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKD---------SICDIHLLQN 629
            :::|..        .|||||:|.:   |:.|:|...|:....:.:.         |..|.:.:..
  Rat   597 LRKTDE--------PRAKEAIITM---ISSVERFIHHVNTCMRQRQERQRLAGVVSRIDAYEVVE 650

  Fly   630 GNGSDLLQY---------------------GRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVK 673
            |:..::.::                     .:|||:|.|.:|..:|.|..: |.|:|..:|::.|
  Rat   651 GSNDEVDKFLKEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDV-YCFLFTDLLLVTK 714

  Fly   674 ALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLAR----KSGKTAFTLYLKSE 734
            |  :|..:.....|.. .|.|         :.:.|:.|.....||..    .|...|:|....|:
  Rat   715 A--VKKAERTKVIRPP-LLVD---------KIVCRELRDPGSFLLIHLNEFHSAVGAYTFQASSQ 767

  Fly   735 HERDKWRKALTEAMESL-----------EPPGCQ 757
            .....|...|..|...|           |.||.|
  Rat   768 ALCRSWVDTLYNAQNQLQQLRAQLLCAQEHPGTQ 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	52/193 (27%)
		PH_Vav	624..753	CDD:269930	31/164 (19%)
		PH	641..749	CDD:278594	29/111 (26%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Plekhg5	XP_038965663.1	RBD_PLEKHG5	172..246	CDD:340588	9/33 (27%)
		RhoGEF	438..624	CDD:214619	55/202 (27%)
		PH_PLEKHG5_G6	681..779	CDD:270064	28/110 (25%)
		Atrophin-1	913..>1077	CDD:397323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910