DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Arhgef2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_006232705.1	Gene:	Arhgef2 / 310635	RGDID:	1304659	Length:	1180	Species:	Rattus norvegicus

Alignment Length:	962	Identity:	203/962 - (21%)
Similarity:	359/962 - (37%)	Gaps:	260/962 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 FHRVLITLSKLSQCR--KVQQLHP---------DLIGFNLQLSPTE-RSHSDEAIYKDLHSTDLN 174
            |||      ..|.|.  ....:||         .:.|.||.|..:: ..:|.::     |:||||
  Rat   130 FHR------GQSFCHLSATSSVHPATGMLSKAVSMSGINLLLDCSDPNGNSSQS-----HATDLN 183

  Fly   175 -----MRKTSSIDASASSSAEY--------YDRTSQSGSLDENSDITIENGTEDIDDYIEDSLSN 226
                 :.:.|...|.:|....:        .|:|.:...:.|..|....||    ..:...|:|.
  Rat   184 KCGKQLEEDSGTWAGSSLRRTFSFLLGMTGRDKTREKEKMKEAKDARYTNG----HLFTTISVSG 244

  Fly   227 M--------------------CDSTIDNDAEDAGVETPLLSDCQGSHVRE-------LSFDLALD 264
            |                    |:.||.|..:|.      |::|  :.|::       |..:.||.
  Rat   245 MTMCYACNKSITAKEALICPTCNVTIHNRCKDT------LANC--TKVKQKQQKAALLRNNTALQ 301

  Fly   265 VVS-----STTDGASNAVTPTPESY------ARQSQSPLAAAAPSVPVSAAPG-----PPMGRLV 313
            .||     :|.:..::|:.|: :|:      :|:..|.| :.|.||..:...|     .|:|...
  Rat   302 SVSLRSKTTTRERPTSAIYPS-DSFRQSLLGSRRGLSSL-SLAKSVSTTNIAGHFNDESPLGLRQ 364

  Fly   314 STSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKP- 377
            ..|.|:.||                |.|:...|.|.    :..|..|..|.:| ...|:...|.
  Rat   365 ILSQSTDSL----------------NMRNRTLSVES----LIDEGVEVFYNEL-MSDFEMDEKDF 408

  Fly   378 EVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDV 442
            |..:.::|.: :.:...:.||....||                       ||.|||.||.:::..
  Rat   409 EADSWSLAVD-SSFLQQHKKEVMKKQD-----------------------VIYELIQTELHHVRT 449

  Fly   443 LTALKTKF-MGPLER-HLNQDELRLIFPRIRELVDIHTKFLDKL----RESLTPNAKVKMAQVFL 501
            |..:...| .|.||. .:..:.::.:||.:.||.||||:||.:|    |::|.|.:    .:.|:
  Rat   450 LKIMTRLFRTGMLEELQMEPEVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGS----TRNFV 510

  Fly   502 DFREPFLI---------------YGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQ 551
            ..|...|:               |.||||....|:....::..:::...|.::|..|...:.:..
  Rat   511 IHRLGDLLISQFSGSNAEQMRKTYSEFCSRHTKALKLYKELYARDKRFQQFIRKMTRSAVLKRHG 575

  Fly   552 LRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERA----KEAMIDVSQYINEVKRDSDHLV 612
            :::.:.:..|||.||.:|::::::.:..:.::|:.|..|    ||.:.:|.|.::|::::: .|.
  Rat   576 VQECILLVTQRITKYPVLINRILQNSHGIEEEYQDLAAALGLVKELLSNVDQDVHELEKEA-RLQ 639

  Fly   613 IIQKVKDSICDIHLLQNGN-GSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKA-- 674
            .|....|......:...|. |.|.|...:|:.||.|..|....:         |..:|:::..
  Rat   640 EIYNRMDPRAQTPVPGKGPFGRDELLRRKLIHDGCLLWKTATGR---------FKDVLLLLMTDV 695

  Fly   675 -LHIKTGDMQY--TYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSG-KTAFTLYLKSEH 735
             :.::..|.:|  |..|..::...       :..|.||...:.:.:....|| ...:.::..|..
  Rat   696 LVFLQEKDQKYIFTSLDKPSVVSL-------QNLIVRDIANQAKGMFLISSGPPEMYEVHAASRD 753

  Fly   736 ERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRC--KVCQIS- 797
            :|..|.:.:.:::..     |.|.:....|.|.|.....|     :|.::.|..:.  ::.|::
  Rat   754 DRTTWIRVIQQSVRL-----CPSREDFPLIETEDKAYLRR-----IKTKLQQKNQALVELLQMNV 808

  Fly   798 ------VHKGCISSTGRCKQNPVSVPPPVCDR---QLSEFNWFAGNMDRETAAHRLENRRIGTYL 853
                  ||...:      |...:.:|||...|   :|..|....|....:.|...:|.  :...|
  Rat   809 ELFAEMVHFQAL------KAGFIGMPPPTLPRGLFRLESFESLRGERLLKDALREVEG--LKDLL 865

  Fly   854 LRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELV------S 912
            |......|.||.|.  ||.::.|......:..|.|            .|.|...:||.      |
  Rat   866 LGPCVDLPLTAREP--ALPVEADSGSCPGVTANGE------------ARTFNGSIELCRADSDSS 916

  Fly   913 YYERNDLGE--------------NFAGLNQSLQ--WPYKEVIATALYDYEPK 948
            ..:||  |.              |..||.|.||  ...:|.:..||:...|:
  Rat   917 QKDRN--GNQLRSPQEEALQPLVNLYGLLQGLQAVVVQQERLMEALFPEGPE 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	3/9 (33%)
		RhoGEF	428..603	CDD:279015	51/199 (26%)
		PH_Vav	624..753	CDD:269930	23/135 (17%)
		PH	641..749	CDD:278594	19/113 (17%)
		C1_1	761..804	CDD:278556	9/51 (18%)
		SH2_Vav_family	824..934	CDD:198193	30/131 (23%)
		SH3	940..993	CDD:302595	3/9 (33%)
Arhgef2	XP_006232705.1	C1_ARHGEF2	230..290	CDD:410427	13/71 (18%)
		RhoGEF	432..626	CDD:238091	51/220 (23%)
		PH_ARHGEF2	666..781	CDD:275428	22/135 (16%)
		SMC_prok_B	<898..>1057	CDD:274008	19/83 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910