DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Bcr

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_038955099.1	Gene:	Bcr / 309696	RGDID:	1307993	Length:	1270	Species:	Rattus norvegicus

Alignment Length:	1080	Identity:	211/1080 - (19%)
Similarity:	356/1080 - (32%)	Gaps:	329/1080 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 WLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFN------------- 78
            |..|....||| .||:|.|....|.....||.         ||:.::..|..
  Rat    75 WGFRRAAQPPD-GAAEPRASAPRLPPAPADGA---------DPAPVEESEARPDGEGSPSKGRPA 129

  Fly    79 --RKPQMA--QFLCSKNIKLFLDVCHNNF-GIR-------DADLFEPTMLYDLTNFH--RVLITL 129
              |:|..|  .....:.....:....:|| .||       .||..:|  .|....||  |.|:.:
  Rat   130 TARRPAAAAPADRDDRGPPTSVAALRSNFEKIRKGPAQPGSADAEKP--FYVNVEFHHERGLVKV 192

  Fly   130 SKLSQCRKVQQLHPDLIGFNLQLS-------------PTERSHSDEA---IYKDLHSTDLNMR-- 176
            :......::..|....:....:.|             |..|..|.|:   :..|....:||.|
  Rat   193 NDKEVSDRISSLGSQAMQMERKKSQQSAGQGLGEAPRPHYRGRSSESSCGLDGDYEDAELNPRFL 257

  Fly   177 KTSSIDASASS-----SAEY--YDRTSQSGSLDE---NSDITIENGTEDIDDYIEDSLSNMCDST 231
            |.:.|:|:..:     ..||  |......|.:.|   .|.:.....|.:    .|..|:....|.
  Rat   258 KDNLINANGGNRPPWPPLEYQPYQSIYVGGMMVEGEGKSPLLRSQSTSE----QEKRLTWPRRSY 318

  Fly   232 IDNDAEDA-GVETPLLSDCQGSHVRELSFDLALDVVSSTTD---GASNAVTPTPESYAR---QSQ 289
            .....||: |..||   ||..:.          ::.||..|   |.|:.|:|:|.:|..   :|:
  Rat   319 SPRSFEDSGGGYTP---DCSSNE----------NLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSR 370

  Fly   290 SPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYI 354
            ||...:..|...|:.|.|...:    ......::|||        |.:...|.:        ..|
  Rat   371 SPSQNSQQSFDSSSPPTPQCQK----RHRQCQVVVSE--------ATIVGVRKT--------GQI 415

  Fly   355 YSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQD--------------- 404
            :..|.:.        |||.:|.....|.    .|.|......:|:..:||
  Rat   416 WPSDGDS--------TFQGEADSSFGTP----PGYGCAADQAEEQRRHQDGLPYIDDSPSSSPHL 468

  Fly   405 ---------LCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERH--- 457
                     ..||..|..|:.......|.|.:|:..::.:|..||..|.||... |.||:..
  Rat   469 SSKGRGSPASGALEPTKASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLP-MKPLKAAATT 532

  Fly   458 ----LNQDELRLIFPRIRELVDIHTKFLDKLRESLTPNA-----KVKMAQVFLDFREPFLIYGEF 513
                |...::..||.::.||.:||.:|.|    .|.|..     :.::..:|........:|..|
  Rat   533 SQPVLTSQQIETIFFKVPELYEIHKEFYD----GLFPRVQQWSHQQRVGDLFQKLASQLGVYRAF 593

  Fly   514 CSLLLGAIDYLADVCKKN----QIIDQLVQKCERDY--NVGKLQLRDILSVPMQRILKYHLLLDK 572
            ......|::.....|:.|    :|.:.|..:..:|.  :..|..|..:|..|:.|:.:..|:|..
  Rat   594 VDNYGVAMETAEKCCQANAQFAEISENLRARSNKDVKDSTTKNSLETLLYKPVDRVTRSTLVLHD 658

  Fly   573 LVKETSPLHDDYRSLERAKEAMIDVSQYINE----------VKRDSDHLVIIQKVKDSICDIHLL 627
            |:|.|...|.|:..|:.|.....:....|||          ||: .:|.   |.:|||.. :.|:
  Rat   659 LLKHTPSSHPDHSLLQDALRISQNFLSSINEEITPRRQSMTVKK-GEHR---QLLKDSFM-VELV 718

  Fly   628 QNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVK--------------ALHIK 678
            :...                          |||:.|:|..:|:..|              ..:|.
  Rat   719 EGAR--------------------------KLRHIFLFTDLLLCTKLKKQSGGKTQQYDCKWYIP 757

  Fly   679 TGDMQYTYRD------------SHNLADYRVEQSHSRRTIGRDTRF----------------KYQ 715
            ..|:.:...|            ...|...:::.|..:..|.|:.|.                :..
  Rat   758 LTDLSFQMVDELEALPNIPLVPDEELDALKIKISQIKSDIQREKRANKGSKVMERLRKKLSEQES 822

  Fly   716 LLLA----------RKSGKTAFTLYLKSEHERDKWRKALTE---------AMESLEPPGCQSTDH 761
            |||.          .::|| ::|..:.|::||.:||:::.|         ::.|:|.....::..
  Rat   823 LLLLMSPSMAFRVHSRNGK-SYTFLISSDYERAEWRESIREQQKKCFKSFSLTSVELQMLTNSCV 886

  Fly   762 KMEIYTFDAPTTCRHC----------SKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSV 816
            |::        |..|.          |..|.|.:|         ..||    |:||..:.:.:
  Rat   887 KLQ--------TVHHIPLTINKEDDESPGLYGFLH---------AIVH----SATGFKQSSNL-- 928

  Fly   817 PPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIK 881
               .|..::..|.:|...  .:|..:|............:..:|..|.....|       :....
  Rat   929 ---YCTLEVDSFGYFVNK--AKTRVYRDTTEPNWNEEFEIELEGSQTLRILCY-------EKCYN 981

  Fly   882 HMKINQEN--SGDSML---------YCLSSRRHFKTIVEL 910
            .||:.:|:  |.|.::         ..|..|...:|::::
  Rat   982 KMKMAKEDGESADKLMGKGQVQLDPQTLQDRDWQRTVIDM 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	30/131 (23%)
		RhoGEF	428..603	CDD:279015	45/192 (23%)
		PH_Vav	624..753	CDD:269930	29/189 (15%)
		PH	641..749	CDD:278594	27/168 (16%)
		C1_1	761..804	CDD:278556	9/52 (17%)
		SH2_Vav_family	824..934	CDD:198193	15/98 (15%)
		SH3	940..993	CDD:302595
Bcr	XP_038955099.1	Bcr-Abl_Oligo	3..75	CDD:401106	211/1080 (20%)
		RhoGEF	501..688	CDD:395496	44/191 (23%)
		PH-like	683..876	CDD:418428	38/224 (17%)
		C2_ABR	912..1032	CDD:176068	22/137 (16%)
		RhoGAP_Bcr	1051..1251	CDD:239852
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910