DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Syde2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_017446301.2	Gene:	Syde2 / 308021	RGDID:	1564206	Length:	1281	Species:	Rattus norvegicus

Alignment Length:	701	Identity:	132/701 - (18%)
Similarity:	214/701 - (30%)	Gaps:	253/701 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 TSQSGSLDENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETP-----LLSDCQGSHV 254
            :|::||...:.|...:.|....:...||....:.......:|..|.::.|     :||....:..
  Rat   443 SSRNGSSAFSEDDADDEGEIWYNPIPEDDSLGIAHVLSLEEANAAALKLPAVRVSMLSARDLAKA 507

  Fly   255 RELSFDLAL------DVVSSTTDG--------ASNAVTPTPESYARQSQSPLAAAAPSVPVSAAP 305
            ...|.||..      ||.:|.::|        :::.|.|..:....::|..|.|.......||..
  Rat   508 ETRSEDLLCPTQHRGDVQTSQSNGINSVDSIHSTDIVQPCRQRLGHRTQESLTAEDSPGLKSAFT 572

  Fly   306 GPPMGRLVST---------------------SSSSSSL------------LVSESQRL-----QR 332
            ||  |.||||                     ||.:.||            |..:.:||     :|
  Rat   573 GP--GILVSTNRTELRALEPPSPSPSPVKKGSSITWSLPDKIKSPRTVRKLSMKMKRLPEFSRKR 635

  Fly   333 AAAAVYNYRSSMASTEHEYAYIYSEDDEKV---------------YEDLCYVTFQAKAKPEVTTD 382
            .|....:|.:|...|.....:.|.|..:.|               :.|....:..:..|..:.:.
  Rat   636 GARGALHYTNSPDRTPPLSKWYYGEGPQSVLLPSGNPASNVISRYHLDTTVSSQHSYQKKPLGSS 700

  Fly   383 NIACNGTGY------------------DHTNTKEEEVYQDLC--------ALHRTSRSQTASSTS 421
            ...|.| ||                  :|...|..|.....|        |....|.|.....:.
  Rat   701 RYPCKG-GYLSDGDSPELRTRSSKHGSEHRLGKGREAVPSGCSKNEIDVGAFRHYSFSDQPKCSQ 764

  Fly   422 F--------------------EQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHL-----NQD 461
            :                    :.:|......:|:.:.....|...:|.|: .|:...     |..
  Rat   765 YISGLMSVHFYGAEGLKPPRIDSKDVFCAIQVDSVNKARTALLTCRTTFL-DLDHTFNIEIENAQ 828

  Fly   462 ELRLIF------PRIRELVDIH-TKFLDKL-RESLTPNAKVKMAQVFLDFREP-FLIYGEFC--- 514
            .|:|:.      || |..|..| |..|..| |.:.|....||:        || .|||.:..
  Rat   829 HLKLVVFSWEPTPR-RNRVCCHGTVVLPALFRVTRTHQLAVKL--------EPRGLIYVKVTLME 884

  Fly   515 --------------SLLLGAIDYLADVCKKNQ--IIDQLVQKC---------------------- 541
                          |::.| :|....|.|:|.  ::..|:|||
  Rat   885 QWENSLHGLDKNRESVMFG-VDIQKVVEKENAGLMVPLLIQKCIMEIEKRGCQVVGLYRLCGSAA 948

  Fly   542 ---------ER-------------DYNVGKLQLRDIL-SVPMQRILK--YHLLLDKLVKETSPLH 581
                     |:             |.||....|:|.| .:|...|.|  |..:||.:||  |||.
  Rat   949 VKKELREAFEKDSKTVGLCEDQYPDINVITGVLKDYLRELPSPLITKQLYQAVLDAMVK--SPLK 1011

  Fly   582 DDYRSLERA---KEAMIDVSQYINEVKRDS-----DHLVIIQKVKD---------SICDIHLLQN 629
            ......|..   ....:|:...:.:|::.:     |||.::....:         ::|
  Rat  1012 MSSNGCENESSDSRFTVDLLNCLPDVEKATLKMLLDHLKLVASYHEVNKMTCQNLAVC------- 1069

  Fly   630 GNGSDLLQYGRLLLDGELHIKAHEDQ----KTKLRYAFVFDKILIMVKALH 676
                    :|.:||:.......|.::    ..:|..|..|.|   .::.||
  Rat  1070 --------FGPVLLNQRQETSTHNNRVFSDSEELASALDFKK---HIEVLH 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	55/257 (21%)
		PH_Vav	624..753	CDD:269930	10/57 (18%)
		PH	641..749	CDD:278594	9/40 (23%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Syde2	XP_017446301.2	PHA03247	<115..324	CDD:223021
		C2	767..882	CDD:417471	26/124 (21%)
		RhoGAP	902..1116	CDD:413382	44/229 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910