DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Arhgef4

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_008765203.2	Gene:	Arhgef4 / 301334	RGDID:	1586179	Length:	1751	Species:	Rattus norvegicus

Alignment Length:	798	Identity:	165/798 - (20%)
Similarity:	285/798 - (35%)	Gaps:	214/798 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 EPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQ-LSPTERSHSDEAIYKDL----HST 171
            :|:.|...|:.....|.:|....|.....|..:..|...: .||..||....|...||    .::
  Rat   928 KPSWLTSATSPGAAQIDISYTLPCSSACHLSYESQGMPCRPTSPKPRSPMAGAQRVDLCLAGRTS 992

  Fly   172 DLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDA 236
            .::|....| |..|:..:|..:|...|.:   .:.:.:...|.:.:|..||..:..|..
  Rat   993 AVSMVSLRS-DRDANRCSEVPERPKASKA---RASLLLSLQTLNQNDQKEDRSTCQCHH------ 1047

  Fly   237 EDAGVET-PLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTPESY---------ARQSQSP 291
               |:.| |.|.|..|:.                    |...:|..|..         |..:|.|
  Rat  1048 ---GLGTVPFLRDLPGNE--------------------STQESPPEEKLGCSHDHNTGAEPTQRP 1089

  Fly   292 LAAA------APSVPVSAAP--GPPMGRLVSTSS--SSSSLLVSESQR--------LQRAAAA-- 336
            ::||      .||:.....|  .|...|.....|  |...|.:.::||        |:|..:.
  Rat  1090 VSAAEVVTWTLPSISAEQVPREAPLQFRRAPQRSHVSFDDLWIEKTQRRKLEKQMLLRRQMSTGL 1154

  Fly   337 -----VYNYR-SSMASTEHEY----AYIYSE---------------------------------- 357
                 |..:| :::.|.|..:    :::.|:
  Rat  1155 ASVDPVQCWRKTTVTSPESPHLPRRSHLLSQSAPMGLDHTGWPEPMPNTGMPDGTLDAVCAEETG 1219

  Fly   358 DDEKVYEDLCYVTFQAKAKP----------EVTTDNIA-CNGTGYDHTNTKEEE-------VYQD 404
            .:|.:|||| :.:....:.|          |:.:|..| |....:||....::|       |.:.
  Rat  1220 SEEDLYEDL-HSSGHHYSHPRGGGEQLAINELISDGSAVCAEALWDHVTMDDQELGFKAGDVIEV 1283

  Fly   405 LCALHR------------------------------------------TSRSQTASSTSFEQRDY 427
            :.|.:|                                          ......|.|...:.|..
  Rat  1284 MDATNREWWWGRVVDGEGWFPASFVRLRVNQDEPADDYEAPRAGAGEADDSGPEAQSCKDQMRTN 1348

  Fly   428 VIRELIDTESNYLDVLTALKTKFMGPLERH---LNQDELRLIFPRIRELVDIHTKFLDKLRESLT 489
            ||.|::.||.:|:..|..:...::....:.   .::::||.||..|.::......|:..|.:...
  Rat  1349 VINEILSTERDYIKHLRDICEGYVRQCRKREDMFSEEQLRTIFGNIEDIYRCQKAFVKALEQKFN 1413

  Fly   490 ---PNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQ 551
               |:.. ::...||:.:..|.||.|:|:....|...|:.:.|.::.: ...:.|.....:..:.
  Rat  1414 TERPHLS-ELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYV-YFFEACRLLQRMIDIS 1476

  Fly   552 LRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQK 616
            |...|..|:|:|.||.|.|.:|:|.|.|.|.|::::|.|..||.:|:|.|||.||..:::..|.:
  Rat  1477 LDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKNVEAALHAMKNVAQLINERKRRLENIDKIAQ 1541

  Fly   617 VKDSICDIHLLQNGNGSDLL-QYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTG 680
            .:.||      ::..|.||| :...|:..|||........:::.|..|:||:.||..|...::..
  Rat  1542 WQSSI------EDWEGEDLLVRSSELIHSGELTRVTQPQARSQQRMFFLFDRQLIYCKKDLLRRD 1600

  Fly   681 DMQYTYR-DSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLY-----------LKS 733
            .:.|..| |..:|....||.       |:|...       ..|.|.||.||           .:.
  Rat  1601 VLYYKGRLDMDDLEVVDVED-------GKDRDL-------HVSVKNAFRLYCGTTGDSHLLCARK 1651

  Fly   734 EHERDKWRKALTEAMESL 751
            ..::.:|.||.....|.:
  Rat  1652 PEQKQRWLKAFAREREQV 1669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	5/19 (26%)
		RhoGEF	428..603	CDD:279015	48/180 (27%)
		PH_Vav	624..753	CDD:269930	33/141 (23%)
		PH	641..749	CDD:278594	28/119 (24%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Arhgef4	XP_008765203.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910