DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Vav3

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_017446264.1	Gene:	Vav3 / 295378	RGDID:	1565941	Length:	875	Species:	Rattus norvegicus

Alignment Length:	1117	Identity:	280/1117 - (25%)
Similarity:	436/1117 - (39%)	Gaps:	387/1117 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQ 85
            |::|..||..|||:|.:|:.....|::..||.|||||||||.|:.:|.|.|::.:|.|.:|||:|
  Rat     4 WKQCAQWLIHCKVLPANHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRPHSINLKEINLRPQMSQ 68

  Fly    86 FLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNL 150
            |||.|||:.||..|.:.||::.::|||...|:|:.:|.:|:.|||:||:.       |..:...:
  Rat    69 FLCLKNIRTFLAACCDTFGMKKSELFEAFDLFDVRDFGKVIETLSRLSRT-------PIALATGI 126

  Fly   151 QLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTED 215
            :..|||.|.:||.|||
  Rat   127 RPFPTEESVNDEDIYK------------------------------------------------- 142

  Fly   216 IDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPT 280
                   .|.::.|.|...|.||       |.||
  Rat   143 -------GLPDLIDETRVEDEED-------LYDC------------------------------- 162

  Fly   281 PESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMA 345

  Rat   163 ----------------------------------------------------------------- 162

  Fly   346 STEHEYAYIYSEDD-EKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALH 409
                    :|.||: .:|||||                             .|.||.:|
  Rat   163 --------VYGEDEGGEVYEDL-----------------------------MKAEEAHQ------ 184

  Fly   410 RTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELV 474
                   |.|...:.|...:.|:..||..|.:.|.:::..||.||:|.|...|...:|..|.:||
  Rat   185 -------AKSQENDIRSCCLAEIRQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPDLV 242

  Fly   475 DIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQ 539
            .:|...:.::.:|:.......:.|||::::|..:|||::||.:..||..|..:.|..:.:...::
  Rat   243 KVHRSLMQEIHDSIVNKDDHNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVRLKLE 307

  Fly   540 KCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHD--DYRSLERAKEAMIDVSQYIN 602
            :|.:..|.||..|||:|.|||||:|||||||.:|||.|   ||  :..:|:.|.:||.|::||:|
  Rat   308 ECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHT---HDPMEKSNLKLALDAMKDLAQYVN 369

  Fly   603 EVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDK 667
            |||||::.|..|::.:.||      :|.| ..:|.:||...|||:.|...:....:.|:.|:||.
  Rat   370 EVKRDNETLREIKQFQLSI------ENLN-QPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDL 427

  Fly   668 ILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLK 732
            .:|:.|    :.|| .|..::..:|..|::  :::..|...:.::.|...|....|:.....|.|
  Rat   428 AVIVCK----RKGD-NYEMKEIIDLQQYKI--ANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCK 485

  Fly   733 SEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQIS 797
            ::..:.||.:....|:.::.|....|..|..:::||...|:||.|...|:|..:|||.|..|...
  Rat   486 TKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCRVCQMLLRGTFYQGYLCFKCGAK 550

  Fly   798 VHKGCISSTGRC------KQNP-------------------------------VSVPPPV----- 820
            .||.|:.....|      :|.|                               ...|||.
  Rat   551 AHKECLGRVDNCGRVNSVEQGPFKPPEKRTNGLRRASRQVDPGLPKMRVIRNYTGTPPPALHEGP 615

  Fly   821 --------------------------------------------CDRQLSEFN---WFAGNMDRE 838
                                                        |..:..:::   |:||.|:|.
  Rat   616 PLHIQAGDTVELLRGEAHTVFWQGRNLASGEVGFFPSDAVKPSPCVPKPVDYSCQPWYAGPMERL 680

  Fly   839 TAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRH 903
            .|...|.||...|||:|:|     |.....||:|:|. :|..||:||...:.    .:.::..|.
  Rat   681 QAETELINRVNSTYLVRLR-----TKESGEYAISIKY-NNEAKHIKILTRDG----FFHIAENRK 735

  Fly   904 FKTIVELVSYYERNDLGENFAGLNQSLQWPYKEV------------------------------- 937
            ||:::|||.||:.:.|.|.|..|:.:||:||||.
  Rat   736 FKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHASGQRGNRTGNSSPPLFCGFSFVTPPDYS 800

  Fly   938 -------------------IATALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTV 983
                               ||.|.||:..: ...:|.|.....|.:..| ..:.|||||::...|
  Rat   801 FVPPSSTPFWSVLSPKVLGIAIARYDFCAR-DMRELSLLKGDMVKIYTK-MSANGWWRGEVNGRV 863

  Fly   984 GYFPKEYVQEQK 995
            |:||..||:|.:
  Rat   864 GWFPSTYVEEDE 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	52/110 (47%)
		RhoGEF	428..603	CDD:279015	64/176 (36%)
		PH_Vav	624..753	CDD:269930	29/128 (23%)
		PH	641..749	CDD:278594	24/107 (22%)
		C1_1	761..804	CDD:278556	17/42 (40%)
		SH2_Vav_family	824..934	CDD:198193	38/112 (34%)
		SH3	940..993	CDD:302595	18/52 (35%)
Vav3	XP_017446264.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4787
eggNOG	1	0.900	-	-		E1_KOG2996
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1691
OMA	1	1.010	-	-		QHG52258
OrthoDB	1	1.010	-	-		D313065at33208
OrthoFinder	1	1.000	-	-		FOG0001414
OrthoInspector	1	1.000	-	-		otm45144
orthoMCL	1	0.900	-	-		OOG6_103071
Panther	1	1.100	-	-	O	PTHR45818
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1295
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840