Protein Alignment Vav and Akap13

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_038961459.1
• Gene: Akap13 / 293024
• RGDID: 727893
• Length: 2793
• Species: Rattus norvegicus
• Alignment Length: 538
• Identity: 104/538 - (19%)
• Similarity: 216/538 - (40%)
• Gaps: 116/538 - (21%)

  Fly   285 ARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEH 349
            ::..:.|.:|...:....|||      :.:...|..|:.:|:|..:|.....  ....:|::|
  Rat  1848 SQPKERPRSAVLLAEEAIAAP------MFTNRRSQQSVSLSKSVSIQNITGV--GNDENMSNT-- 1902

  Fly   350 EYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCA----LHR 410
             :.::....|.  ...:|        |...:|:::...|.|   |:..|.::..|..:    |..
  Rat  1903 -WKFLSHSTDS--LNKIC--------KVNESTESLTDEGVG---TDMNEGQLMGDFESDSKQLEA 1953

  Fly   411 TSRSQTASSTSFEQ-------RDYVIRELIDTESNYLDVLTALKTKFMGPLERHL--NQDELRLI 466
            .|.|:|..|...:|       |..||.||:.||.:::..|..:...:...:...|  .|..:..:
  Rat  1954 ESWSRTVDSKFLKQQKKDVVKRQEVIYELMQTELHHIRTLKIMSDVYSRGMMTDLLFEQQMVEKL 2018

  Fly   467 FPRIRELVDIHTKF----LDKLRESLTPNAKVKMAQVFLDFREPFLI------------------ 509
            ||.:.||:.||::|    |::.:|||...::           :.|||
  Rat  2019 FPCLDELISIHSQFFQRILERKKESLVDKSE-----------KNFLIKRIGDVLVSQFSGENAER 2072

  Fly   510 ----YGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLL 570
                ||:||.....:::|..|:..|::.....|:|......|.:|.:.:.:.:..|||.||.:|.
  Rat  2073 LKKTYGKFCGQHNQSVNYFKDLYTKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLF 2137

  Fly   571 DKLV---KETSPLHDDY-RSLERAKEAM--ID--VSQY-----INEVKRDSDHLVIIQKVKDSIC 622
            .:::   |:.....:|. :||...|:.:  :|  |:.|     :.|:...:|...|::
  Rat  2138 QRILQCTKDNEVEQEDLTQSLSLVKDVIGAVDSKVASYEKKVRLGEIYTKTDSKSIMR------- 2195

  Fly   623 DIHLLQNGN--GSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYT 685
                :::|.  ..:.|:..:|:.||.:.:|:...:..:::...:.| ||:.     ::..|.:|.
  Rat  2196 ----MKSGQMFAKEDLRRKKLVRDGSVFLKSATGRLKEVQAVLLTD-ILVF-----LQEKDQKYV 2250

  Fly   686 YRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSG---KTAFTLYLKSEHERDKWRKALTEA 747
            :..    .|::......::.|.|:...:.:.|.....|   .....::..|..||:.|.:.:.:.
  Rat  2251 FAS----LDHKSTVISLKKLIVREVAHEEKGLFLISMGVKDPEMVEVHASSREERNSWIQIIQDT 2311

  Fly   748 MESL---EPPGCQSTDHK 762
            :.||   |..|..|.:.:
  Rat  2312 INSLNRDEDEGIPSENEE 2329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/215 (22%)
		PH_Vav	624..753	CDD:269930	22/136 (16%)
		PH	641..749	CDD:278594	18/110 (16%)
		C1_1	761..804	CDD:278556	0/2 (0%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Akap13	XP_038961459.1	PHA03307	545..>837	CDD:223039
		C1_AKAP13	1769..1824	CDD:410428
		RhoGEF	1975..2169	CDD:238091	46/204 (23%)
		PH_AKAP13	2212..2314	CDD:275427	18/111 (16%)
		SMC_prok_B	<2509..>2669	CDD:274008

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910