DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Vav and Pura

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_996016.2 Gene:Pura / 2768948 FlyBaseID:FBgn0035802 Length:1904 Species:Drosophila melanogaster


Alignment Length:784 Identity:164/784 - (20%)
Similarity:274/784 - (34%) Gaps:247/784 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 NFHRVLITLSKLSQ------------CRKVQQLHP--DLIGFNLQLSPTERSHSDEA------IY 165
            :.|...:.:|.||:            .:|::..|.  |..|..|.|. |:....:.|      :.
  Fly  1104 DLHAAALKVSVLSESANNLKSALDQFAQKLELAHERYDAAGRLLHLL-TQHQRENAAREELQRLA 1167

  Fly   166 KDLHSTDL------NMRKT------SSIDASASSSAEYYDRTSQS------GSLDENSDITIEN- 211
            :.|.:|.|      .||||      ||..|:|:.....|..:|.|      |....|.....|: 
  Fly  1168 EQLGATSLLEKHWPVMRKTHTLPVASSTPAAAAGKRVSYRCSSASRSSFEGGPSSSNCSCWRESR 1232

  Fly   212 GTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNA 276
            ..||:|...|           :.:.:|        .||.|.                  ||    
  Fly  1233 NLEDMDQMEE-----------EEEEQD--------HDCDGG------------------DG---- 1256

  Fly   277 VTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSS----SSSSLLVSESQRLQRAAAAV 337
                     .:.||.:|.:...|..:....|.:.|:.|..|    |...||  |.:...|.:   
  Fly  1257 ---------EEQQSKIADSGLGVCDNCERNPKLARICSCQSLNEKSHDELL--EDECFDRPS--- 1307

  Fly   338 YNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKE---- 398
                                   |.|.|:.:...:|.|       ::.|:|:..:....:|    
  Fly  1308 -----------------------KRYMDIMHSPMEANA-------HLQCHGSSLELPKLEELSCL 1342

  Fly   399 -EEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDE 462
             .::.:.|..:.|....        .:|||| |.|.....||:|.|  |:.....||....|   
  Fly  1343 DPKIQKTLLLIMREMIG--------TERDYV-RSLYYVIENYIDEL--LREDIPQPLRGQRN--- 1393

  Fly   463 LRLIFPRIRELVDIH-TKFLDKL-RESLTPNAKVKMAQVFLDFREPFLIYGEF------CSLLLG 519
              :||..|.::.:.| :.||.:| |....|   :|:...||:....|.:|..:      ...||.
  Fly  1394 --VIFGNIEKIFEFHNSHFLGELERYERNP---LKVGAAFLEMESKFYLYALYNKNKPKSDTLLS 1453

  Fly   520 AIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVK-----ETSP 579
              :|.:...|..|:  ||..         ||.|...|..|:||:.||.|||.:|||     |.:.
  Fly  1454 --EYGSSFFKPKQM--QLQD---------KLDLASYLLKPVQRMGKYALLLQQLVKACKGVEGAA 1505

  Fly   580 LHD---DYRSLERAKEAMIDVSQYINEVK---RDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQY 638
            |.:   |...|:||:|.          ||   |..:.|:.:..::|  ||:::.:.         
  Fly  1506 LQEIAADVEELQRAEEM----------VKFQLRHGNDLLAMDSLRD--CDVNVKEQ--------- 1549

  Fly   639 GRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSR 703
            ||||...|..:......|..||..|:|:::::..||..         :.|..||..|..:.|...
  Fly  1550 GRLLRQNEFLVWQGRGGKKTLRQVFLFEELVLFSKARR---------FPDHKNLDIYIYKNSIKT 1605

  Fly   704 RTIG-----RDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTE---------------AM 748
            ..||     .|:..|:::...::.....:.|...||..::.|.:.:::               .|
  Fly  1606 SDIGLTAHTGDSATKFEIWFRKRKPDDTWMLQCMSEDIKNAWTEEISKLLWKQAKRNREVRLAEM 1670

  Fly   749 ES----------LEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCI 803
            .|          :.|...|.:|..:.:...:.....|| |:..||.:.:. ...:.:.|:..|..
  Fly  1671 SSMGIGSKPCLDIRPSNNQISDRSIPLAQLNKTPKLRH-SEPGKGSMRRP-NSLISESSLSSGTS 1733

  Fly   804 SSTG 807
            :::|
  Fly  1734 TTSG 1737

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723 2/10 (20%)
RhoGEF 428..603 CDD:279015 54/190 (28%)
PH_Vav 624..753 CDD:269930 27/158 (17%)
PH 641..749 CDD:278594 23/127 (18%)
C1_1 761..804 CDD:278556 7/42 (17%)
SH2_Vav_family 824..934 CDD:198193
SH3 940..993 CDD:302595
PuraNP_996016.2 PX_domain 15..>52 CDD:295365
RhoGEF 1353..1532 CDD:279015 61/220 (28%)
PH_puratrophin-1 1524..1663 CDD:270062 31/158 (20%)
PH 1562..1655 CDD:278594 20/101 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45462287
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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