DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and TIAM2

DIOPT Version :10

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_036586.3 Gene:TIAM2 / 26230 HGNCID:11806 Length:1701 Species:Homo sapiens


Alignment Length:885 Identity:179/885 - (20%)
Similarity:319/885 - (36%) Gaps:255/885 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   123 HRV--LITLSKLSQCRKVQQLHPDLIGFNLQ---------LSPTERSHSDEAIYKD-----LHST 171
            |||  ::||:    | |::||.|...|..|:         ..|....:..:.:|.:     |:..
Human   830 HRVEDILTLA----C-KMRQLEPSHYGLQLRKLVDDNVEYCIPAPYEYMQQQVYDEIEVFPLNVY 889

  Fly   172 DLNMRKTSSI-DASASSSAEYYDRTSQSGSLDENSDITIENGTEDIDDYIEDSLSNMCDSTIDND 235
            |:.:.||.|: |...:.:|:..:|...|...              |.|.:.|.|           
Human   890 DVQLTKTGSVCDFGFAVTAQVDERQHLSRIF--------------ISDVLPDGL----------- 929

  Fly   236 AEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVP 300
            |...|:.       :|:.:..|:.:...|:                  ..:|.::..:..:..:.
Human   930 AYGEGLR-------KGNEIMTLNGEAVSDL------------------DLKQMEALFSEKSVGLT 969

  Fly   301 VSAAPGPPMGRLVSTSSSSSSLLVSESQRL-------QRAAAAVYNYRSSMASTEHEYAYIYSED 358
            :.|.| |.....:.||.|.|.|...:.:.|       |.....:.|::.   :|.::::.:    
Human   970 LIARP-PDTKATLCTSWSDSDLFSRDQKSLLPPPNQSQLLEEFLDNFKK---NTANDFSNV---- 1026

  Fly   359 DEKVYEDLCYVTFQAKAKPEVTT--DNIACNGTGYDHTNTKE--EEVY---QDLCALHRTSRSQT 416
                              |::||  .....:|| .|..:.:|  |:.:   :.:.||.|:.....
Human  1027 ------------------PDITTGLKRSQTDGT-LDQVSHREKMEQTFRSAEQITALCRSFNDSQ 1072

  Fly   417 ASSTS--FEQRD-----------------YVIRELIDTESNYLDVLTALKTKFMGPL--ERHLNQ 460
            |:...  .|.:|                 .||:||:|||.:|:..|:.|...::.||  |..|.|
Human  1073 ANGMEGPRENQDPPPRSLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQ 1137

  Fly   461 DELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFRE-------PFLIYGEFCSLLL 518
            ||:..:|..:.|:::....||:.|.:.::.::.....:....||:       .||.|.:...|..
Human  1138 DEMESLFGSLPEMLEFQKVFLETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFKLYS 1202

  Fly   519 GAIDYLADVCKKNQIIDQLVQKCERD---------YNVGKLQ---LRDILSVPMQRILKYHLLLD 571
            |       .|..:..:.:::::.:.|         .|..|..   |...|..|:||:|||.|||.
Human  1203 G-------FCANHIKVQKVLERAKTDKAFKAFLDARNPTKQHSSTLESYLIKPVQRVLKYPLLLK 1260

  Fly   572 KLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKR--DSDHLVIIQKVKDSICDIHLLQNGNGSD 634
            :||..|....:::..|..|.:||..|:.:|||:::  :....|..|.|.:        |:|...:
Human  1261 ELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAE--------QSGTEKE 1317

  Fly   635 L--LQYGRLLLDGELHI--------KAHEDQKTKLRYAFVFDKILIMVKALHIK-TGDMQYTYRD 688
            :  |..|.||:...:..        ||.:|.:..:   |||.:.:|:|...:.| ...:....|.
Human  1318 VTELSMGELLMHSTVSWLNPFLSLGKARKDLELTV---FVFKRAVILVYKENCKLKKKLPSNSRP 1379

  Fly   689 SHNLADYRVEQSHSRRTIGRDTRFKYQLL-----LARKSGKTAFT--------LYLKSEHERDKW 740
            :||..|.              ..||::.|     |..:.|..|.|        ::.|||.|    
Human  1380 AHNSTDL--------------DPFKFRWLIPISALQVRLGNPAGTENNSIWELIHTKSEIE---- 1426

  Fly   741 RKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKV-CQISVHKGCIS 804
                 ...|::....|..::.|..|.            |.::..:.:.:|..: |::.:.|.|..
Human  1427 -----GRPETIFQLCCSDSESKTNIV------------KVIRSILRENFRRHIKCELPLEKTCKD 1474

  Fly   805 STGRCKQN-PVSVPPPVCDRQL-----SEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPST 863
            .....|.. |||. .....|.|     |..|.:.|    ||....|.:...|:.....:..|..|
Human  1475 RLVPLKNRVPVSA-KLASSRSLKVLKNSSSNEWTG----ETGKGTLLDSDEGSLSSGTQSSGCPT 1534

  Fly   864 AHETMYALSLKTD-----------DNVIKHMKINQENSGD 892
            |.....:.|....           ||:||...|..:...|
Human  1535 AEGRQDSKSTSPGKYPHPGLADFADNLIKESDILSDEDDD 1574

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH_VAV 19..135 CDD:409050 5/13 (38%)
RhoGEF 428..602 CDD:459876 52/194 (27%)
PH_Vav 624..753 CDD:269930 31/152 (20%)
C1_VAV 759..810 CDD:410360 7/51 (14%)
SH2_Vav_family 824..934 CDD:198193 18/85 (21%)
SH3 940..993 CDD:473055
TIAM2NP_036586.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..250
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 265..293
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 389..417
PH1_Tiam1_2 505..631 CDD:269937
Tiam_CC_Ex 645..742 CDD:408184
Ubl1_cv_Nsp3_N-like 811..881 CDD:475130 14/55 (25%)
PDZ 887..976 CDD:214570 20/139 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1070..1092 3/21 (14%)
RhoGEF 1103..1292 CDD:214619 53/195 (27%)
PH2_Tiam1_2 1294..1466 CDD:269957 40/217 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1500..1556 11/59 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1568..1628 1/7 (14%)
Blue background indicates that the domain is not in the aligned region.

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