DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and GAS2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001378862.1	Gene:	GAS2 / 2620	HGNCID:	4167	Length:	331	Species:	Homo sapiens

Alignment Length:	115	Identity:	24/115 - (20%)
Similarity:	39/115 - (33%)	Gaps:	40/115 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   639 GRLLLDGELHIKAHEDQKTKLRYAFVFDKI----------LIMVKALH----IKTGDMQYTYRDS 689
            |.||.|....|.  ||...|....|..:::          ::.::.||    |.|...:.|::..
Human   199 GNLLDDAVKRIS--EDPPCKCPNKFCVERLSQGRYRVGEKILFIRGLHGCDYISTAKAKQTFKML 261

  Fly   690 HN-------------LADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTA 726
            ||             .|.|.::....|           .|.::|..|||:
Human   262 HNKHVMVRVGGGWETFAGYLLKHDPCR-----------MLQISRVDGKTS 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930	24/115 (21%)
		PH	641..749	CDD:278594	23/113 (20%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
GAS2	NP_001378862.1	CH_GAS2	29..163	CDD:409116
GAS2	NP_001378862.1	GAS2	200..291	CDD:413356	18/103 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910