DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and PLEKHG3

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_011534929.1	Gene:	PLEKHG3 / 26030	HGNCID:	20364	Length:	1391	Species:	Homo sapiens

Alignment Length:	885	Identity:	182/885 - (20%)
Similarity:	305/885 - (34%)	Gaps:	310/885 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 PTPESYARQ--SQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYR 341
            |:|.|.||.  |.|.....:...|||         |.||:|||.|...|               |
Human    14 PSPGSNARMPVSTSLHQDGSQERPVS---------LTSTTSSSGSSCDS---------------R 54

  Fly   342 SSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLC 406
            |:|....                     :.:|.||          ||.|             .|.
Human    55 SAMEEPS---------------------SSEAPAK----------NGAG-------------SLR 75

  Fly   407 ALHRTSRSQTASS--------TSFEQR----------DY---VIRELIDTESNYLDVLTALKTKF 450
            :.|..:.:..:||        :.|..|          .|   |:||:::||..|:..|.::...:
Human    76 SRHLPNSNNNSSSWLNVKGPLSPFNSRAAAGPAHHKLSYLGRVVREIVETERMYVQDLRSIVEDY 140

  Fly   451 MGPL---ERHLNQDELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGE 512
            :..:   ...|..:::..:|..|..:..::::.|..| :|...: .|.:|..|::..:.|.||.:
Human   141 LLKIIDTPGLLKPEQVSALFGNIENIYALNSQLLRDL-DSCNSD-PVAVASCFVERSQEFDIYTQ 203

  Fly   513 FCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGK------------LQLRDILSVPMQRILK 565
            :|:....::..|.:              |.||....|            |.|...|..|:|||||
Human   204 YCNNYPNSVAALTE--------------CMRDKQQAKFFRDRQELLQHSLPLGSYLLKPVQRILK 254

  Fly   566 YHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNG 630
            |||||.::.|......|.:..:|.|.:.|..|:.|||::||..:|.|.:|:::.      ||.|.
Human   255 YHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQS------LLINW 313

  Fly   631 NGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADY 695
            .|.||..||.|:|:|...:....:::|    .|:|||.|::.|    |.|| .:.|:.:...:..
Human   314 KGPDLTTYGELVLEGTFRVHRVRNERT----FFLFDKTLLITK----KRGD-HFVYKGNIPCSSL 369

  Fly   696 RVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKW----RKALTEAMESLEPPGC 756
            .:.:|.........|.:|:        .|..:::..|:..|:..|    ::.:.|...:..|...
Human   370 MLIESTRDSLCFTVTHYKH--------SKQQYSIQAKTVEEKRNWTHHIKRLILENHHATIPQKA 426

  Fly   757 QSTDHKMEIYTFDAPTTCRHCSKFLK----------GRIHQGYR---------CKVCQISVHKGC 802
            :....:|:.|   .|...|...:.||          ..:.||.|         .:....|..:|.
Human   427 KEAILEMDSY---YPNRYRCSPERLKKAWSSQDEVSTNVRQGRRQSEPGHSPYSRATLPSGQRGF 488

  Fly   803 I--SSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLE----NRRIGTYLLRVRPQGP 861
            :  |..||.|    |.|.....|||:|....||.....:|...|:    :|..|   |:...:|.
Human   489 VMPSLKGRRK----SEPTKHLLRQLNEKARAAGMKHAGSAGTLLDFGQPSRTRG---LQPEAEGA 546

  Fly   862 STAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLG------ 920
            :...|       :.::.|::..:..:|           ..:.|:..:|.::.:|.|:.|
Human   547 TQEEE-------EEEEEVVEEEEEEEE-----------EEQAFQVSLEDLTGHEGNEKGAGPEPP 593

  Fly   921 ----------------ENFAGLNQSLQ-----WPYKEVIATAL---------------------- 942
                            |..|....||.     |.|:   |.||
Human   594 GSEEEEEEQEESLAVAEQVADFASSLLAALHCWHYR---ANALLFSRGAMGKGRRESESSRSSRR 655

  Fly   943 -----------------------YDYEPKAGSNQ-----------------------LQLRTDCQ 961
                                   .:.:|:|||.|                       |:.:.|..
Human   656 PSGRSPTSTEKRMSFESISSLPEVEPDPEAGSEQEVFSAVEGPSAEETPSDTESPEVLETQLDAH 720

  Fly   962 VLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQEQK-LASEE 1000
            ..::|.|..         ||.|.:...|..::.| |:|||
Human   721 QGLLGMDPP---------GDMVDFVAAESTEDLKALSSEE 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	47/189 (25%)
		PH_Vav	624..753	CDD:269930	30/132 (23%)
		PH	641..749	CDD:278594	22/111 (20%)
		C1_1	761..804	CDD:278556	11/63 (17%)
		SH2_Vav_family	824..934	CDD:198193	24/140 (17%)
		SH3	940..993	CDD:302595	15/120 (13%)
PLEKHG3	XP_011534929.1	RhoGEF	118..292	CDD:279015	47/189 (25%)
		PH_PLEKHG1_G2_G3	274..417	CDD:270063	41/165 (25%)
		PH	338..414	CDD:278594	18/92 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940