Protein Alignment Vav and tiam-1

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_491367.3
• Gene: tiam-1 / 259373
• WormBaseID: WBGene00015704
• Length: 889
• Species: Caenorhabditis elegans
• Alignment Length: 813
• Identity: 160/813 - (19%)
• Similarity: 289/813 - (35%)
• Gaps: 223/813 - (27%)

  Fly    56 DGVLLCNLVIHLDPSSLDPRE--FNRKPQMAQ------FLCSKNIKLFLDVCHNNFGIRDADLFE 112
            |.:..|:........||:|..  ||.|....:      |.||...:..:|:.|.|
 Worm   142 DSIQPCDEQPETSNVSLNPLNMVFNYKGSPVEIDLLECFACSSEAENCVDIAHAN---------- 196

  Fly   113 PTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRK 177
                    |..||:::                             :|:...:.:.|:.:.|.:.:
 Worm   197 --------NIFRVIVS-----------------------------AHAHLFLIQALNVSSLLLAR 224

  Fly   178 TSSIDASASSSAEYYDRTSQS-GSLDENSDITIENGTEDIDDYI----------EDSLSNMCDST 231
            |:|...:.:..|...|:..|. .:|.|.|:.:.....|||...:          .:||.......
 Worm   225 TTSNLVAINYLARQNDKIQQKLIALLETSESSENASKEDIRQMLLLKNVVVTQRLNSLQQRALPG 289

  Fly   232 IDNDAEDAG--VETPLLSDCQGS-----HVRELSFDL---ALDVVSSTTDGASNAVTPTPESYAR 286
            |:....|..  ::..||..|:..     |....||.:   .::.....|.|:|.|.|   ..|.:
 Worm   290 IELIQHDISPQIDQKLLEKCRLPSLFLYHFNMNSFRIWRKPMETRDMNTMGSSMAST---SQYHQ 351

  Fly   287 -----QSQSPLAAAA----------PSVPVSAAPG--------PPMGRLVSTSSSSSSLLVSESQ 328
                 |:|:||.:..          |...|:...|        |...||...|.:....|...|:
 Worm   352 IPIQIQNQNPLPSQQIQPQQQQQYHPPDHVTTHNGTTTFHTTNPTKPRLCEGSLAPGCSLAEASE 416

  Fly   329 RLQRAAAAVYNYRSSMASTEHEYA---------YIYSEDDEKVYE-DLCYVTFQAKAKPEVTTDN 383
            :.:|..|......:..:|.|..:.         .||:.:|:.|.. ::..||..|....:|....
 Worm   417 QRKREMAEQKKELAGPSSAEDYFVRKTNGRLGLTIYAHNDDGVIRAEVRGVTSFAPRCAQVGDSV 481

  Fly   384 IACNGTGYDHTNTKE--EEVYQDLCALH---RTSRSQTASS----------TSFEQRDYVIRELI 433
            :|.:...........  |::.:....:|   :|..:..|.|          |...:....::||:
 Worm   482 VAVDSELISSVRNASDVEKLLRIGKVIHLRRKTPLTPRAPSQLDATNVNKKTGCAKLAMALQELL 546

  Fly   434 DTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELVD-------IHTKFLDKLRESLTPN 491
            .||..|:..|            |.:|  |:.|...::|::::       :.|.|:|.:.|::...
 Worm   547 VTEKKYVSDL------------REMN--EVFLCMRQVRDIMNAAIRLYKMQTSFVDSIEEAIGDM 597

  Fly   492 AK--VKMAQ----------VFLDFREPFLIYGEFCS---LLLGAIDYLADVCKKNQIIDQL-VQK 540
            ::  :.:||          ||::....|.||.|:.:   ||...|....::..|.:.::.. .|.
 Worm   598 SRQDISVAQIRDSVMRVCAVFINKCSDFKIYAEYAAGYHLLQHEIKNKKELLSKLEAVNSTREQH 662

  Fly   541 CERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYR---SLERAKEAMIDVSQYIN 602
            |..:..:.|         |:|||::|.|||..:   ...|..|.|   .:|.|.:.|...::|:|
 Worm   663 CSWESRMIK---------PVQRIVQYPLLLKNI---ADALPKDARERVQVEAALQKMQTSAEYVN 715

  Fly   603 EVKR-DSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLD-GELHIKAH---EDQKTKLRYA 662
            |::| ..|:...::.|:.:           ...:|....|.|| .||.:.||   .|...:....
 Worm   716 EMQRLHEDYAQYMETVRKA-----------NEPMLAEKSLRLDTRELLVFAHIKWRDAPAEHYVV 769

  Fly   663 FVFDKILIMV-------------KALHIKTGDMQYTYRDSHNLADYRV-------EQSHSR-RTI 706
            |||..:::::             :.|.|...|:.....|:.||..|..       :.|||. .|:
 Worm   770 FVFHSLILLLPSYARKEIKMKWTRVLPINEVDINEMPNDALNLKLYHAAFEGPNGQLSHSNPNTV 834

  Fly   707 GR----DTRFKYQLLLARKSGKTAFTLYLKSEH 735
            ..    .::.|..|:   |:.|.|.||:.:..|
 Worm   835 YNIECCQSQLKQHLI---KNIKKARTLFSRESH 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	17/83 (20%)
		RhoGEF	428..603	CDD:279015	45/200 (23%)
		PH_Vav	624..753	CDD:269930	31/141 (22%)
		PH	641..749	CDD:278594	30/124 (24%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
tiam-1	NP_491367.3	RhoGEF	541..715	CDD:238091	45/199 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030