DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and tagln2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_963870.1	Gene:	tagln2 / 259183	ZFINID:	ZDB-GENE-020802-2	Length:	201	Species:	Danio rerio

Alignment Length:	148	Identity:	35/148 - (23%)
Similarity:	62/148 - (41%)	Gaps:	22/148 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LRDGVLLCNLVIHLDPSSLDPRE-------FNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLF 111
            |:||.:||.|:..|...|...::       |.:..|::|||.:.          ..:||..:|:|
Zfish    56 LKDGCILCELINSLFKDSKPVKKIQSSSMAFKQMEQISQFLTAA----------ERYGITKSDIF 110

  Fly   112 EPTMLY---DLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTDL 173
            :...|:   ||......|::|..|:..:.......|...|..:.....|..|:|.: |:.||. :
Zfish   111 QTVDLWEGKDLAAVQMTLLSLGSLAVTKDDGCYRGDPAWFPKKSHENRREFSEEQM-KEGHSV-I 173

  Fly   174 NMRKTSSIDASASSSAEY 191
            .:...::|.||.:....|
Zfish   174 GLHMGTNIGASQAGMTGY 191

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	22/87 (25%)
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
tagln2	NP_963870.1	SCP1	14..187	CDD:227526	34/142 (24%)
		CH	25..131	CDD:278723	21/84 (25%)
		Calponin	173..196	CDD:278814	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910