DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and PLEKHG4

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001123199.1	Gene:	PLEKHG4 / 25894	HGNCID:	24501	Length:	1191	Species:	Homo sapiens

Alignment Length:	456	Identity:	94/456 - (20%)
Similarity:	171/456 - (37%)	Gaps:	109/456 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 PPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSED-DEKVYEDLCY-- 368
            ||:|       |::||.||:..    ||.|....|.         ||.:..: .:.:.|..|:
Human   650 PPVG-------STASLCVSQVP----AAPAHPPLRK---------AYSFDRNLGQSLSEPACHCH 694

  Fly   369 --VTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRS----QTASSTSFEQRDY 427
              .|..|..:||.        |.|                ||.:.|.:    .::...|..:...
Human   695 HAATIAACRRPEA--------GGG----------------ALPQASPTVPPPGSSDPRSLNRLQL 735

  Fly   428 VIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELR----LIFPRIRELVDIHTKFLDKLRESL 488
            |:.|::.||..|:..|......:...|:|......||    .:|..:.:|.|.|..|..:..|:.
Human   736 VLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEAC 800

  Fly   489 TPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGK---- 549
            |.:.. ::|..||..|..|.:|..:              .|.....|.|:......:...|
Human   801 TRHPP-RVAYAFLRHRVQFGMYALY--------------SKNKPRSDALMSSYGHTFFKDKQQAL 850

  Fly   550 ---LQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHL 611
               |.|...|..|:||:.||.|||.:|.:.......:..:|..| ::::..     :::..:|.|
Human   851 GDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREA-QSLVHF-----QLRHGNDLL 909

  Fly   612 VIIQKVKDSI--CDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKA 674
            .:     |:|  ||::|.:.         |:|:...|..::.  .:...:|..|:|:::|:..|.
Human   910 AM-----DAIQGCDVNLKEQ---------GQLVRQDEFVVRT--GRHKSVRRIFLFEELLLFSKP 958

  Fly   675 LHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDK 739
            .|..||...:.|:.|..:||..:.:...      ::..::::...|:..:..|.|...|...:..
Human   959 RHGPTGVDTFAYKRSFKMADLGLTECCG------NSNLRFEIWFRRRKARDTFVLQASSLAIKQA 1017

  Fly   740 W 740
            |
Human  1018 W 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	41/185 (22%)
		PH_Vav	624..753	CDD:269930	21/117 (18%)
		PH	641..749	CDD:278594	19/100 (19%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
PLEKHG4	NP_001123199.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..152
		SPEC	447..>598	CDD:321951
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	707..728		5/44 (11%)
		RhoGEF	736..906	CDD:306973	41/190 (22%)
		PH_puratrophin-1	899..1034	CDD:270062	27/147 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1176
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910