DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and RASGRP3

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001132960.1	Gene:	RASGRP3 / 25780	HGNCID:	14545	Length:	690	Species:	Homo sapiens

Alignment Length:	627	Identity:	122/627 - (19%)
Similarity:	212/627 - (33%)	Gaps:	221/627 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 EVYQDLCALHRTSRSQTAS----STSFEQRDYVIR---------ELIDTESNYLDVLTALKTKFM 451
            |:.:.|..::|.:..::.:    ...:..|.::::         .||.....:.:|.:.|
Human    50 ELAEKLLCMYRNATGESCNEFRLKICYFMRYWILKFPAEFNLDLGLIRMTEEFREVASQL----- 109

  Fly   452 GPLERHLNQDELRLIFPRIRELVDIHT-KFLDKLRESLTPNAKVK---MAQVFLDFREP------ 506
             ..|:|::             |:||.: ...|.:|. :|...||.   .|.:..|..||
Human   110 -GYEKHVS-------------LIDISSIPSYDWMRR-VTQRKKVSKKGKACLLFDHLEPIELAEH 159

  Fly   507 --FLIYGEFCSLLLGAIDYLADV---CKKNQIIDQLVQKCERDYN-VGKLQLRDILS--VPMQR- 562
              ||.:..|  ..:...||.:.|   |.:|   :..:::....:| :.|.....:||  .|.||
Human   160 LTFLEHKSF--RRISFTDYQSYVIHGCLEN---NPTLERSIALFNGISKWVQLMVLSKPTPQQRA 219

  Fly   563 --ILKYHLLLDKL--VKETSPLHD-----DYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVK 618
              |.|:..:..||  :|..:.|..     .:.|:.|.||....:|..:.:...:...||
Human   220 EVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELV------ 278

  Fly   619 DSICDIHLLQNGNGSDLLQYGRLLLDGE--------LHIK----AH-------EDQKTKL----R 660
                    ..|||   ...|.:...|.:        :|:|    .|       |:.|..:    :
Human   279 --------SSNGN---YCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQ 332

  Fly   661 YAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKT 725
            .:....:::.:..|.|....:|     |..||....::..|:     .|..:|..|:|..::.|:
Human   333 LSVTLSELVSLQNASHHLEPNM-----DLINLLTLSLDLYHT-----EDDIYKLSLVLEPRNSKS 387

  Fly   726 AFT-------------------------------------LYLKSEHERDKWRKALTEAMESL-- 751
            ..|                                     ::...:|:.|.:  ...|..||:
Human   388 QPTSPTTPNKPVVPLEWALGVMPKPDPTVINKHIRKLVESVFRNYDHDHDGY--ISQEDFESIAA 450

  Fly   752 -------------EPPGCQSTD----------------------HKMEIYTFDAPTTCRHCSKFL 781
                         :..|..|.|                      |..:..|:..||.|.||:.||
Human   451 NFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFL 515

  Fly   782 KGRIHQGYRCKVCQISVHKGC----ISSTGRCKQNPV------SVP-----PPVCDRQLSEFNWF 831
            .|.|.|||:||.|..:.||.|    :.:..|..:.|.      |:|     ||..| ::.||
Human   516 WGIIKQGYKCKDCGANCHKQCKDLLVLACRRFARAPSLSSGHGSLPGSPSLPPAQD-EVFEF--- 576

  Fly   832 AGNMDRETAAHR-LENRRI-----GTYLLRVRPQGPSTAHET 867
                ...||.|| |::|.|     .:..:.||.|..:|:..|
Human   577 ----PGVTAGHRDLDSRAITLVTGSSRKISVRLQRATTSQAT 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	44/211 (21%)
		PH_Vav	624..753	CDD:269930	28/203 (14%)
		PH	641..749	CDD:278594	22/167 (13%)
		C1_1	761..804	CDD:278556	20/46 (43%)
		SH2_Vav_family	824..934	CDD:198193	14/50 (28%)
		SH3	940..993	CDD:302595
RASGRP3	NP_001132960.1	REM	11..126	CDD:100121	13/94 (14%)
		RasGEF	148..384	CDD:214539	52/267 (19%)
		EF-hand_7	428..478	CDD:316058	8/51 (16%)
		C1	495..544	CDD:237996	20/48 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910