DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and pex13

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_593611.1	Gene:	pex13 / 2543046	PomBaseID:	SPAC3C7.10	Length:	288	Species:	Schizosaccharomyces pombe

Alignment Length:	133	Identity:	30/133 - (22%)
Similarity:	57/133 - (42%)	Gaps:	25/133 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   881 KHMKINQENSGDSMLYCLSSRRHFKTIVELVSY-----------YERNDLGENFAGLNQSLQWP- 933
            ||.||::.||.:..::......|..:|..:||.           |....|.:|.....:.:|..
pombe   152 KHSKIDEMNSQEYDVFEKEEGNHKNSIYSIVSSLAIILGLVGLPYAIIRLFKNIYEKEKQIQQAK 216

  Fly   934 -YKEV----IATALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSKG----WWRG--KIGDTVGYFP 987
             .|::    ...|.|::..:....::.|:....:.::.|. |::|    ||:|  :.|:| |:||
pombe   217 IRKKIDSLEFCKADYEFMSRDPGVEMSLKKGDIIAILSKT-DTQGNPCEWWQGRKRSGET-GWFP 279

  Fly   988 KEY 990
            ..|
pombe   280 SNY 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193	14/65 (22%)
		SH3	940..993	CDD:302595	15/57 (26%)
pex13	NP_593611.1	Peroxin-13_N	86..202	CDD:282008	11/49 (22%)
pex13	NP_593611.1	SH3_Pex13p_fungal	226..285	CDD:212705	15/59 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030