DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and scd1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_594221.1	Gene:	scd1 / 2542337	PomBaseID:	SPAC16E8.09	Length:	872	Species:	Schizosaccharomyces pombe

Alignment Length:	572	Identity:	126/572 - (22%)
Similarity:	229/572 - (40%)	Gaps:	135/572 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 TFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELID 434
            |.::.:.|..:||:....||               |.:|..:.|..||             ||.:
pombe   202 TTKSSSTPSPSTDDNVPTGT---------------LNSLIASGRRVTA-------------ELYE 238

  Fly   435 TESNYLDVLTALKTKFMGPLERH--LNQDELRLIFPRIRELVDIHTKFLDKLRESLT-PNAKVKM 496
            ||..|:..|..| :.:|..|::.  |:||.:..||..:.|::|...:||..|..:|: |..:.::
pombe   239 TELKYIQDLEYL-SNYMVILQQKQILSQDTILSIFTNLNEILDFQRRFLVGLEMNLSLPVEEQRL 302

  Fly   497 AQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQ 561
            ..:|:...|.|.:|..||:....|...:.|  .:||:: ::....|..|     :|..:|..|:|
pombe   303 GALFIALEEGFSVYQVFCTNFPNAQQLIID--NQNQLL-KVANLLEPSY-----ELPALLIKPIQ 359

  Fly   562 RILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHL 626
            ||.||.|||::|:|.|...:.....|::....::.|:..:||.:|..::...|.:::..:.|
pombe   360 RICKYPLLLNQLLKGTPSGYQYEEELKQGMACVVRVANQVNETRRIHENRNAIIELEQRVID--- 421

  Fly   627 LQNGNGSDLLQYGRLLLDGELHI-KAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSH 690
               ..|..|..:|:||:...::: ||..:::   .:.::|:|||:..|.:
pombe   422 ---WKGYSLQYFGQLLVWDVVNVCKADIERE---YHVYLFEKILLCCKEM--------------- 465

  Fly   691 NLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPG 755
                         .|:.|..|    .:...|..|...:|.||.        :.||..:.::.|
pombe   466 -------------STLKRQAR----SISMNKKTKRLDSLQLKG--------RILTSNITTVVP-- 503

  Fly   756 CQSTDHKMEIYTFDAPTTCRHCSKFLKG-RIHQGYRCKVCQISVHKGCISSTGRCK--------- 810
                :|.|..|....         |.:| ..|:.:..|:.....||..:|...|..
pombe   504 ----NHHMGSYAIQI---------FWRGDPQHESFILKLRNEESHKLWMSVLNRLLWKNEHGSPK 555

  Fly   811 --QNPVSVPP-PVCDRQLSEFNWFAGNMDRE-TAAHRLENR-----RIGTYLLRVRPQGPSTAHE 866
              ::..|.|. ||.:|..|:.:....:.|.: ...|.|:..     .|.:...:..|...:|:.:
pombe   556 DIRSAASTPANPVYNRSSSQTSKGYNSSDYDLLRTHSLDENVNSPTSISSPSSKSSPFTKTTSKD 620

  Fly   867 TMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERND 918
            |..|.:  ||:.....:::|.|.|..:     ||.|..:|...:||    ||
pombe   621 TKSATT--TDERPSDFIRLNSEESVGT-----SSLRTSQTTSTIVS----ND 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	49/177 (28%)
		PH_Vav	624..753	CDD:269930	22/129 (17%)
		PH	641..749	CDD:278594	19/108 (18%)
		C1_1	761..804	CDD:278556	9/43 (21%)
		SH2_Vav_family	824..934	CDD:198193	22/101 (22%)
		SH3	940..993	CDD:302595
scd1	NP_594221.1	CDC24	105..194	CDD:283938
		RhoGEF	232..401	CDD:279015	51/190 (27%)
		PH_Scd1	404..546	CDD:270066	37/205 (18%)
		PB1	775..848	CDD:214770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940