DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and bzz1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_596017.1	Gene:	bzz1 / 2539679	PomBaseID:	SPBC12C2.05c	Length:	642	Species:	Schizosaccharomyces pombe

Alignment Length:	696	Identity:	146/696 - (20%)
Similarity:	244/696 - (35%)	Gaps:	184/696 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   391 YDHTNTKEEEVYQDLCAL-----HRTSRSQTASS--------------TSFEQRDYVIRELIDTE 436
            |...::.|:|..|.|.:|     .:.||..:|.|              .|......::.||..:.
pombe    37 YKERSSIEKEYAQKLASLSNKYGEKKSRKSSALSVGDTPAMSAGSLECASLTTWSKILDELTRSS 101

  Fly   437 SNY--------LDVLTALKTKFMGPLERHLNQDELRLIFPRIRELVDIHTKFLDKLRESLTPNAK 493
            ..:        ||:...||     .||.|:  :.||.::.      |::.||..: :|:|..:
pombe   102 KTHQKLSDDYSLDIAEKLK-----KLESHI--EALRKVYD------DLYKKFSSE-KETLLNS-- 150

  Fly   494 VKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSV 558
            ||.|:|         .|.|.|       |.|....:||....:  ||.:|:..:.:..:.|..:.
pombe   151 VKRAKV---------SYHEAC-------DDLESARQKNDKYRE--QKTQRNLKLSESDMLDKKNK 197

  Fly   559 PMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVK--------------RDSD 609
            .:.|:|.|:....|...||.|             .:::..|.:||.:              ..|.
pombe   198 YLLRMLVYNAHKQKFYNETLP-------------TLLNHMQVLNEYRVSNLNEIWCNSFSIEKSL 249

  Fly   610 HLVIIQKVKDSICDIHLLQNGNGSDLLQYGR-----LLLDGELHIKA----HEDQ--------KT 657
            |..:.|:..:...:|  .:|....|...:||     ..|..:||.:.    |:..        |.
pombe   250 HDTLSQRTVEIQSEI--AKNEPVLDSAMFGRHNSKNWALPADLHFEPSPIWHDTDALVVDGSCKN 312

  Fly   658 KLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKS 722
            .||...|..|     ..|..:.|::  ...|| .|...||:..:|     .:..|:.:.......
pombe   313 YLRNLLVHSK-----NDLGKQKGEL--VSLDS-QLEGLRVDDPNS-----ANQSFESKKASINLE 364

  Fly   723 GKTAFTLYLKSEHERDKWR-KALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIH 786
            ||   .|.:|:..|..:.| ..:|....:||..|   ..|..:..:|..||:|.:|.:.:.|...
pombe   365 GK---ELMVKARIEDLEVRINKITSVANNLEEGG---RFHDFKHVSFKLPTSCSYCREIIWGLSK 423

  Fly   787 QGYRCKVCQISVHKGC-ISSTGRCKQNPVSVPPPVCD--------RQLSEFNWFAGNMD-----R 837
            :|..||.|....|..| :.....||..    .|.|.|        ....:|:..|.:.:     |
pombe   424 RGCVCKNCGFKCHARCELLVPANCKNG----EPEVADDDAVDTSVTATDDFDASASSSNAYESYR 484

  Fly   838 ETAAHRLENRRI-GTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSR 901
            .|....:::..| .|.|..|:.:      ||..|......|.|:.: ....|:.|   :...|..
pombe   485 NTYTDDMDSSSIYQTSLSNVKTE------ETTPAEPASKVDGVVLY-DFTGEHEG---VITASEG 539

  Fly   902 RHFKTIVE-----------------LV--SYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEP 947
            :.| |::|                 |:  ||.:.||      .||.|:..........|||.|..
pombe   540 QEF-TLLEPDDGSGWVRVKIDGTDGLIPASYVKLND------ELNTSVTLDGDSSYVKALYAYTA 597

  Fly   948 KAGSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQE 993
            :: ..:|.:: :..::.:.......||..|.:....|.||..||.:
pombe   598 QS-DMELSIQ-EGDIIQVTNRNAGNGWSEGILNGVTGQFPANYVTD 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	39/182 (21%)
		PH_Vav	624..753	CDD:269930	31/146 (21%)
		PH	641..749	CDD:278594	25/120 (21%)
		C1_1	761..804	CDD:278556	13/43 (30%)
		SH2_Vav_family	824..934	CDD:198193	27/134 (20%)
		SH3	940..993	CDD:302595	13/52 (25%)
bzz1	NP_596017.1	FCH	6..107	CDD:214492	13/69 (19%)
		C1_1	398..447	CDD:278556	13/48 (27%)
		SH3_Bzz1_1	519..572	CDD:212845	11/57 (19%)
		SH3	588..640	CDD:302595	12/53 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910