Protein Alignment Vav and Vav1

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_036891.2
• Gene: Vav1 / 25156
• RGDID: 3951
• Length: 843
• Species: Rattus norvegicus
• Alignment Length: 1082
• Identity: 293/1082 - (27%)
• Similarity: 446/1082 - (41%)
• Gaps: 353/1082 - (32%)

  Fly    19 DLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQM 83
            :|||:|..||.:|:|:||.|:.....|::..||..||||||||.|:.:|.|.:::.||.|..|||
  Rat     2 ELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLCQLLNNLLPHAINLREVNLWPQM 66

  Fly    84 AQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGF 148
            :||||.|||:.||..|...||::.::|||...|:|:.:|.:|:.|||.||.....|  :..::.|
  Rat    67 SQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQ--NKGIMPF 129

  Fly   149 NLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGT 213
                 |||    |.|:                                               |.
  Rat   130 -----PTE----DSAL-----------------------------------------------GD 138

  Fly   214 EDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVT 278
            ||    |...||:..|.|.:.| ||       |.||
  Rat   139 ED----IYSGLSDQIDDTAEED-ED-------LYDC----------------------------- 162

  Fly   279 PTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSS 343
                                                                             
  Rat   163 ----------------------------------------------------------------- 162

  Fly   344 MASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCAL 408
               .|:|.|    |.|| :||||
  Rat   163 ---VENEEA----EGDE-IYEDL------------------------------------------ 177

  Fly   409 HRTSRSQTASS----TSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPR 469
               .||::..:    |.:::|...:||:..||..|.|.|.:::..||.||:|.|...::..||..
  Rat   178 ---MRSESVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVN 239

  Fly   470 IRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQII 534
            |.||:.:||.||.:|:::|:......:.|||:.::|.||:||.:||.:..|..:|..|....:.:
  Rat   240 IEELLSVHTHFLKELKDALSGPGATMLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREDV 304

  Fly   535 DQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQ 599
            ...:::|.:..|.|:..|||:|.|||||:|||||||.:|||.|... .:..:|..|.:||.|::|
  Rat   305 QMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDT-TEKENLRLALDAMRDLAQ 368

  Fly   600 YINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFV 664
            .:||||||::.|..|...:.||.::       ...|..|||..:||||.|.:.|.:....||||:
  Rat   369 CVNEVKRDNETLRQITNFQLSIENL-------DQSLANYGRPKIDGELKITSVERRSKTDRYAFL 426

  Fly   665 FDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDT-RFKYQLLLARKSGKTAFT 728
            .||.|::.|    :.|| .|..:.|.||..::|....|..   ||. ::.:..||....|...:.
  Rat   427 LDKALLICK----RRGD-SYDLKASVNLHSFQVRDDSSGE---RDNKKWSHMFLLIEDQGAQGYE 483

  Fly   729 LYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKV 793
            |:.|:...:.||.:....|:.::.|....:..|..::::|:..|:|:.|...|:|..:|||||..
  Rat   484 LFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYR 548

  Fly   794 CQISVHKGCISSTGRC---------------------KQNPV------------SVPPP------ 819
            |:...||.|:.....|                     |:|.:            .:|||
  Rat   549 CRAPAHKECLGRVPPCGRQDFSGTMKKDKLHRRAQDKKRNELGLPKMEVCQEYYGIPPPPGAFGP 613

  Fly   820 -----------------------------------VCDR----------QLSEFNWFAGNMDRET 839
                                               .|:|          .||...|:||.|:|..
  Rat   614 FLRLNPGDIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVRPYVHGPPQDLSVHLWYAGPMERAG 678

  Fly   840 AAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNV-IKHMKINQENSGDSMLYCLSSRRH 903
            |...|.||..||||:|.|.:  .||.   :|:|:|.  || :||:||.....    ||.::.::.
  Rat   679 AEGILTNRSDGTYLVRQRVK--DTAE---FAISIKY--NVEVKHIKIMTSEG----LYRITEKKA 732

  Fly   904 FKTIVELVSYYERNDLGENFAGLNQSLQWPYKEV-----------------IATALYDYEPKAGS 951
            |:.:.|||.:|::|.|.:.|..|:.:||:||||.                 .|.|.||:..:..|
  Rat   733 FRGLPELVEFYQQNSLKDCFKSLDTTLQFPYKEPERRAINKPPVGSTKYFGTAKARYDFCARDRS 797

  Fly   952 NQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQE 993
             :|.|:....:.::.|.| .:|||||:|...:|:||..||:|
  Rat   798 -ELSLKEGDIIKILNKKG-QQGWWRGEIYGRIGWFPSNYVEE 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050	55/115 (48%)
		RhoGEF	428..602	CDD:459876	66/173 (38%)
		PH_Vav	624..753	CDD:269930	36/129 (28%)
		C1_VAV	759..810	CDD:410360	17/71 (24%)
		SH2_Vav_family	824..934	CDD:198193	41/110 (37%)
		SH3	940..993	CDD:473055	19/52 (37%)
Vav1	NP_036891.2	CH_VAV1	2..121	CDD:409111	55/118 (47%)
		RhoGEF	195..371	CDD:238091	67/176 (38%)
		PH_Vav	385..508	CDD:269930	38/137 (28%)
		C1_VAV1	510..566	CDD:410417	17/55 (31%)
		SH3_VAV1_1	594..656	CDD:212912	5/61 (8%)
		SH2_Vav1	663..765	CDD:198268	43/112 (38%)
		SH3_VAV1_2	784..837	CDD:212909	20/54 (37%)