DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Stac3

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001346680.1	Gene:	Stac3 / 237611	MGIID:	3606571	Length:	360	Species:	Mus musculus

Alignment Length:	290	Identity:	62/290 - (21%)
Similarity:	105/290 - (36%)	Gaps:	70/290 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   723 GKTAFTLYLKSEHERDKWRKALTEAMESLEPPG-CQSTDHKMEIYTFDAPTTCRHCSKFLKGRIH 786
            |...:.:|.:.|.|.:       |.....|||. .....||.:.:.|..|..|..|::.:.....
Mouse    57 GGPIYYIYEEEEEEEE-------EEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNK 114

  Fly   787 QGYRCKVCQISVHKGCIS--STGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHR----LE 845
            .|.|||.|:.::|:.|.|  ...||..   .:||..  |:......::......:||:|    .|
Mouse   115 FGLRCKNCKTNIHEHCQSYVEMQRCFG---KIPPGF--RRAYSSPLYSDQQYAVSAANRNDPVFE 174

  Fly   846 NRRIGTYLL-RVRPQGPSTAHETMYAL-----------SLKTDD--NVIKHMKINQENSGDSMLY 896
            ..|:|..:. :.|.:|.:.....:.|:           ..|:.|  |..|..|..::...|....
Mouse   175 TLRVGVIMANKERKKGQADKKNPLAAMMEEEPESARPEEGKSQDGNNAEKDKKAEKKTPDDKNKQ 239

  Fly   897 CLSSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQ 961
            ....:.|:...:......|::||                        |:.|..           :
Mouse   240 PGFQQSHYFVALYRFKALEKDDL------------------------DFPPGE-----------K 269

  Fly   962 VLVIGKDGDSKGWWRGKIGDTVGYFPKEYV 991
            :.||  |..::.|||||||:.||:||..::
Mouse   270 ITVI--DDSNEEWWRGKIGEKVGFFPPNFI 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930	5/29 (17%)
		PH	641..749	CDD:278594	5/25 (20%)
		C1_1	761..804	CDD:278556	13/42 (31%)
		SH2_Vav_family	824..934	CDD:198193	19/127 (15%)
		SH3	940..993	CDD:302595	16/52 (31%)
Stac3	NP_001346680.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..86		8/35 (23%)
		C1_1	89..134	CDD:365894	14/44 (32%)
		STAC2_u1	146..>187	CDD:374707	7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..241		9/53 (17%)
		SH3_Stac3_1	247..299	CDD:212919	19/88 (22%)
		SH3_Stac_2	306..356	CDD:212768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910