Protein Alignment Vav and MCF2L

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_001425319.1
• Gene: MCF2L / 23263
• HGNCID: 14576
• Length: 1214
• Species: Homo sapiens
• Alignment Length: 993
• Identity: 203/993 - (20%)
• Similarity: 361/993 - (36%)
• Gaps: 304/993 - (30%)

  Fly    89 SKNIKLFLDV----CHNNFGIRDADLFEP----------TMLYD----LTNFHRVLITLSKLSQC 135
            |:.|..|.|:    .|....:||...||.          .:..|    :.|.|..:.::.  .:|
Human   374 SQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGEQLIGNKHYAVDSIR--PKC 436

  Fly   136 RKVQQL----------HPDLIGFNLQLS---PTERSHSDEAIYKDLHSTDLNMRKTSSIDASASS 187
            ::::.|          ...|:..:|:|.   .|.....||.||         :..:..:|..
Human   437 QELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEGIY---------LLASQPVDKC--- 489

  Fly   188 SAEYYDRTSQSGSLDENSDITIENGTEDIDDYIEDSLSNMCD--STIDNDAEDAGVETPLLSDCQ 250
                   .||.|:         |...::|:.::|....|...  :.|..:.|.      :|:...
Human   490 -------QSQDGA---------EAALQEIEKFLETGAENKIQELNAIYKEYES------ILNQDL 532

  Fly   251 GSHVREL-SFDLALDVVSSTTDGASNAVTPTPESYARQSQ--SPLAAAAPSVPVSAAPGPPMGRL 312
            ..|||:: ....:::.|......:...:.      |||::  .|:|....::..|..|.|.:.|
Human   533 MEHVRKVFQKQASMEEVFHRRQASLKKLA------ARQTRPVQPVAPRPEALAKSPCPSPGIRR- 590

  Fly   313 VSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKP 377
               .|.:||   ||...|:|..     ||                                :||.
Human   591 ---GSENSS---SEGGALRRGP-----YR--------------------------------RAKS 612

  Fly   378 EVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLD- 441
            |::...   .|.|    :..|||  :.|..|.|                :|:.||:|||..|::
Human   613 EMSESR---QGRG----SAGEEE--ESLAILRR----------------HVMSELLDTERAYVEE 652

  Fly   442 ---VLTALKTKFMGPLERHLNQDELR----LIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQV 499
               ||.....:...||..||....|.    ::|..:.|:...|.:...:..|:.|...:: :.:.
Human   653 LLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDCPEL-VGRC 716

  Fly   500 FLDFREPFLIYGEFC-------SLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILS 557
            ||:..|.|.||.::|       ||.....|     |       ...|:|:|..: .||.|...|.
Human   717 FLERMEDFQIYEKYCQNKPRSESLWRQCSD-----C-------PFFQECQRKLD-HKLSLDSYLL 768

  Fly   558 VPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSIC 622
            .|:|||.||.|||.:::|.:       |:.|.|:    |:.:.::.:      |.|::.|.||
Human   769 KPVQRITKYQLLLKEMLKYS-------RNCEGAE----DLQEALSSI------LGILKAVNDS-- 814

  Fly   623 DIHLL----QNGNGSDLLQYGRLLLDGEL---------HIKAHEDQKTK--LRYAFVFDKILIMV 672
             :||:    .:||..||   |:||:.|..         |.|..|..:.|  .|:.|:.:|.::..
Human   815 -MHLIAITGYDGNLGDL---GKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFC 875

  Fly   673 KALHIKTGD-----MQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLL-ARKSGKTAFTLYL 731
            |... :.|:     ..|:|:.|.|:|...:.::     :..|.: |:::.. ||:.   .:.:..
Human   876 KKRE-ENGEGYEKAPSYSYKQSLNMAAVGITEN-----VKGDAK-KFEIWYNAREE---VYIVQA 930

  Fly   732 KSEHERDKW----RKALTEAMESLEPPGCQSTDHKMEIYTFDAPTT---CRHCSKFLKGRIHQGY 789
            .:...:..|    ||.||..:::...........:.:.....|||:   .|..|:.:| ::.:.
Human   931 PTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIK-KLEER- 993

  Fly   790 RCKVCQISVHKGCISSTGRCKQNPVSVPP---------------PVCDRQLSEFNWFAGNMDRET 839
              |...:|: :|.:||.      |::.||               ....|:......|| |:..:.
Human   994 --KTDPLSL-EGYVSSA------PLTKPPEKGKDDTVTSSASESSALSRKRFTLQGFA-NLKGQK 1048

  Fly   840 AAHRLENRRIGTYLLRVRPQ--GPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRR 902
            |:....:::...:.::..|.  |.....:|.::|....||......: .|.||.|:
Human  1049 ASPTSPDKKAKRHEVKSDPTPFGVRGWSKTSHSLEAPEDDGGWSSAE-EQINSSDA--------- 1103

  Fly   903 HFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQVLVIGK 967
                              |...||......|.|   .|.:.|:| |.|.:.|::|:. .|:.:.:
Human  1104 ------------------EEDGGLGPKKLVPGK---YTVVADHE-KGGPDALRVRSG-DVVELVQ 1145

  Fly   968 DGDSKGWW-----RGKIG 980
            :||...|:     .||.|
Human  1146 EGDEGLWYVRDPTTGKEG 1163

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050	12/63 (19%)
		RhoGEF	428..602	CDD:459876	51/188 (27%)
		PH_Vav	624..753	CDD:269930	33/153 (22%)
		C1_VAV	759..810	CDD:410360	11/53 (21%)
		SH2_Vav_family	824..934	CDD:198193	17/111 (15%)
		SH3	940..993	CDD:473055	14/46 (30%)
MCF2L	NP_001425319.1	None