DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Arhgef16

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_011248543.1	Gene:	Arhgef16 / 230972	MGIID:	2446219	Length:	721	Species:	Mus musculus

Alignment Length:	681	Identity:	130/681 - (19%)
Similarity:	241/681 - (35%)	Gaps:	175/681 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 ASSSAEYYDRTSQSGSLDE-------NSDITIENGTEDID--DYIEDSLSNMCDSTIDNDA---- 236
            |||......|.|.| ||||       ::::.::.....|.  ..:..||....::..:.||
Mouse     3 ASSVTSMSQRHSDS-SLDEKLLEYRFHAELRLDANGNPIPGLPMVRSSLKARANAAFEPDASEPL 66

  Fly   237 ------EDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTPESY----------- 284
                  ||.....|::...|.....::.   ...::..:...||.|.|.:|..:
Mouse    67 PPPPSPEDEEPPRPIVLSTQSPAALKMG---TQQLIPKSLAVASKAKTKSPARHQSFGAAVLSKE 128

  Fly   285 -ARQSQSPLAAAAPSVPVS-------------------------AAPGPPMGRLVSTSSSSSSLL 323
             ||  ::|...:|||..:.                         ..||||      :|...|..|
Mouse   129 AAR--RNPQLFSAPSFSLDDMDMDMVTTGNLRRNLRNQSYRAAMKGPGPP------SSKGDSVQL 185

  Fly   324 VSESQRLQRAAA------AVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTD 382
            ..:.|.|...||      ...|.::......|:.::   :||.::|:::
Mouse   186 GPKLQALAEEAAQPPSRYPAKNKKTLGRKRAHKGSF---KDDPQLYQEI---------------- 231

  Fly   383 NIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQT---------------------------ASST 420
                ...|.:.::..::::..:......|.|:.|                           ..||
Mouse   232 ----RERGLNTSHESDDDILDEPSGPVGTQRADTTIVVKSYRPAQLTWSQLPEVLESGVLDTLST 292

  Fly   421 SFEQRDYVIRELIDTESNYLDVLTALKTKFM--GPLERHLNQDELRLIFPRIRELVDIHTKFLDK 483
            ...:|...|.|::.:|.:||..|:.|.|:|:  ..|...:.|.|...:|..|.:::....||.:.
Mouse   293 EERKRQEAIFEILTSEFSYLHSLSILVTEFLQSRELRATMTQTEHHHLFSNILDVMSASQKFFEA 357

  Fly   484 LRESLTPNAKVK-MAQVFLDFRE----PFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCER 543
            |.:.......|: ::.:..|..:    |::.|   ||..:.....|..:...|.....::::.|:
Mouse   358 LEQRHKAQVCVEDISDILEDHAQHHFHPYIAY---CSNEVYQQRTLQKLSNSNAAFRDVLKEIEK 419

  Fly   544 DYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINE----- 603
            ....|.|.:...|.:||||:.:..||.|.|..:|....:.|::..:|.:|:..:.:..||
Mouse   420 RPACGGLPMISFLILPMQRVTRLPLLTDTLCLKTQGHPERYKAASQALKAISKLVKQCNEGAHKM 484

  Fly   604 VKRDSDHLVIIQ----KVKDSICDIHLLQNGNGSDLLQYGRLLLD-GELHIKAHEDQKTKLR--- 660
            .:.:..:.:.:|    |||             ...|:...|.||. |||.:........|:.
Mouse   485 ERTEQIYTLNMQLDFGKVK-------------SLPLISASRWLLKRGELFLLEESSIFRKIASRP 536

  Fly   661 --YAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTI--GRDTR-------FKY 714
              |.|:|:.:|::.|    |..:..|..:|...|...:|.:......:  |..:|       |:.
Mouse   537 TCYLFLFNDVLVVTK----KKSEESYLVQDYAQLDHVQVRKLEPSEPLLPGGSSRSSSVPYPFQV 597

  Fly   715 QLLLARKSGKTAFTLYLKSEHERDKWRKALT 745
            .||...:..:....|...|..:|.:|..|||
Mouse   598 NLLHNSEGRQEQILLSSDSASDRARWITALT 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	41/181 (23%)
		PH_Vav	624..753	CDD:269930	30/137 (22%)
		PH	641..749	CDD:278594	28/120 (23%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Arhgef16	XP_011248543.1	RhoGEF	300..478	CDD:366202	41/180 (23%)
		PH_ephexin	501..634	CDD:269929	33/145 (23%)
		SH3_ARHGEF16_26	645..696	CDD:212871
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910