Protein Alignment Vav and Frmd5

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_011237768.1
• Gene: Frmd5 / 228564
• MGIID: 2442557
• Length: 599
• Species: Mus musculus
• Alignment Length: 570
• Identity: 110/570 - (19%)
• Similarity: 182/570 - (31%)
• Gaps: 218/570 - (38%)

  Fly   412 SRSQTASSTSFEQRDY--VIRELIDTE----------SNYL-DVLTALKTKFMGPLERHLNQDE- 462
            ||..:.||.|.| |:|  .:|.|.|:|          ..|| |:|.           .|||..|
Mouse     3 SRLMSGSSRSLE-REYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLC-----------HHLNLLEK 55

  Fly   463 ----LRLIFP-RIRELVDIHTKFLDKLRES--LTPNAKVKMAQ--------------VFLDFREP 506
                :|.:.| :.|..::.....:.:||..  .|...:||...              |||..:..
Mouse    56 DYFGIRFVDPDKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRD 120

  Fly   507 FLIYGEFCSLLLGAIDYLADVCKKNQ---IIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHL 568
             |.:|..             :||.:.   :...::|....||:.||..  :..|...|...|:.
Mouse   121 -LYHGRL-------------LCKTSDAALLAAYILQAEIGDYDPGKHP--EGYSSKFQFFPKHS- 168

  Fly   569 LLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQ--NGN 631
              :||.|:.:.:|....|      .....:..:|.:::       .|.::....|.|..:  :||
Mouse   169 --EKLEKKIAEIHKTELS------GQTPATSELNFLRK-------AQTLETYGVDPHPCKDVSGN 218

  Fly   632 GSDL--LQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVK---ALHIKTGDMQYTYRDSHN 691
            .:.|  ..:|.::|.|...:.              |.|.::...   |:|...|     ::|...
Mouse   219 AAFLAFTPFGFVVLQGNKRVH--------------FIKCILFASFTAAIHWAGG-----FKDFST 264

  Fly   692 LADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGC 756
            :....:..:..       |:.|::       ||| |.||:..:.|
Mouse   265 ITPKPLSWNEV-------TKLKFE-------GKT-FYLYVSQKEE-------------------- 294

  Fly   757 QSTDHKMEIYTFDAPT--TCRHCSK-------------------------FLKG-RIHQGYRCKV 793
                 |..|.|:.|||  .|:|..|                         |.|| |.....|
Mouse   295 -----KKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGR--- 351

  Fly   794 CQISVHKGCISSTGRCKQNPVS------VPPPVCDR-----QLSEFNWFAGNMDRETAAH----- 842
                |.|..:.|:.:.|:.|..      ||...|..     :||..     ...|..|.|
Mouse   352 ----VAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSV-----PRTRRRAVHISIME 407

  Fly   843 RLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGD 892
            .||:.|...:...||    |::|          .|..:.|::.::.:|.:
Mouse   408 GLESLRDSAHSTPVR----SSSH----------GDTFLPHVRSSRADSNE 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	40/210 (19%)
		PH_Vav	624..753	CDD:269930	22/135 (16%)
		PH	641..749	CDD:278594	17/110 (15%)
		C1_1	761..804	CDD:278556	16/70 (23%)
		SH2_Vav_family	824..934	CDD:198193	15/74 (20%)
		SH3	940..993	CDD:302595
Frmd5	XP_011237768.1	B41	19..210	CDD:214604	43/233 (18%)
		PH-like	191..324	CDD:388408	34/198 (17%)
		FA	338..383	CDD:370090	13/51 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910