DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Arhgef4

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001355702.1	Gene:	Arhgef4 / 226970	MGIID:	2442507	Length:	1855	Species:	Mus musculus

Alignment Length:	991	Identity:	186/991 - (18%)
Similarity:	311/991 - (31%)	Gaps:	321/991 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 CKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIKLF 95
            |:..||.|...|.      :::..:.||:.......|......|..:|.|....   ....||..
Mouse   834 CQGEPPLHHVHQS------VSLETKSGVIQVGTSGDLSGEGPSPESYNIKRLKT---TESKIKAR 889

  Fly    96 LDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQL-----------HPDLI--- 146
            |.:.|..|    .:.||..:: :.||...|.....|..:.|...:.           .|.|:
Mouse   890 LALAHKTF----TNFFEAKVM-EKTNTGSVKGEKEKRRRARGSWRAFLRSKDAEGSKRPALVSGV 949

  Fly   147 ---GFNLQL---SPTERSH-------SDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTS-- 196
               ||...|   .|..|.|       :|..::.: |.|.||  ..:::.:|..:|.|:..|:.
Mouse   950 PEPGFPQLLCSSPPATRGHCEKWTIDTDSHVFGE-HWTPLN--SPATLSSSHLASPEHRRRSEPT 1011

  Fly   197 -------------QSGSLDENSDIT--IENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPL- 245
                         .||...::|.:|  ...|...||.......|:.|..|.:|........:|.
Mouse  1012 IRRTAAQESSTHLSSGVFPKSSWLTSATSPGAAQIDISFALPCSSACHLTYENQGMPCRPTSPKP 1076

  Fly   246 LSDCQGSHVRELSF---DLALDVVSSTTDGASNAVTPTP-------------------------- 281
            .|...|:...:|..   ..|:.:||..:|..:|..:..|
Mouse  1077 RSPMAGAQRMDLCLRGRTSAVSMVSLRSDKDANRSSEVPERPKASKARASLLLSLQTLNQNDQKE 1141

  Fly   282 -----------------------ESYARQSQSP-----------LAAAAPSVPVSAAPGPPMGRL 312
                                   |||..|...|           .....|..||||.      .:
Mouse  1142 DKSQCQCYHGLGTVPFLRDHPGNESYIAQESPPDKKRNCSHDQKTYTEPPHRPVSAT------EV 1200

  Fly   313 VSTSSSSSSLLVSESQRLQRAAAAVYNY----------------RSSMASTEHEYAYIYSEDDEK 361
            ..|..|.|:..|.....||...|..:::                :..|.......|.:..||..:
Mouse  1201 TRTLPSMSAEQVPREVPLQFRRAPQHSHFSFDDIWLEKAQRRKLKKQMLLRRQMCAELVPEDPVQ 1265

  Fly   362 VYEDLCYVTFQA-----------------------------KAKPEVTTDNIACNGTGYDHTNTK 397
            .:......:.::                             ...|:.|.|.:....||      .
Mouse  1266 CWRKTTITSPESPHLPRRSHLLSQSAPMGLDHTGWPEPTSDTGMPDGTLDTVCAEETG------S 1324

  Fly   398 EEEVYQDL-----------------------------CA------------------------LH 409
            ||::|::|                             ||                        :.
Mouse  1325 EEDLYEELHNSGHHYSHPRGGGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMD 1389

  Fly   410 RTSR---------------------------------------------SQTASSTSFEQRDYVI 429
            .|:|                                             ...|.|...:.|..||
Mouse  1390 ATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDYEAPRAGAREADDSGPEAQSCKDQMRTNVI 1454

  Fly   430 RELIDTESNYLDVLTALKTKFMGPLERH---LNQDELRLIFPRIRELVDIHTKFLDKLRESLT-- 489
            .|::.||.:|:..|..:...::....:.   .::::||.||..|.::......|:..|.:...
Mouse  1455 NEILSTERDYIKHLRDICEGYVRQCRKREDMFSEEQLRTIFGNIEDIYRCQKAFVKALEQKFNTE 1519

  Fly   490 -PNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLR 553
             |:.. ::...||:.:..|.||.|:|:....|...|:.:.|.::.: ...:.|.....:..:.|.
Mouse  1520 RPHLS-ELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYV-YFFEACRLLQRMIDISLD 1582

  Fly   554 DILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVK 618
            ..|..|:|:|.||.|.|.:|:|.|.|.|.|::::|.|..||.:|:|.|||.||..:::..|.:.:
Mouse  1583 GFLLTPVQKICKYPLQLAELLKYTHPQHRDFKNVEAALHAMKNVAQLINERKRRLENIDKIAQWQ 1647

  Fly   619 DSICDIHLLQNGNGSDLL-QYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDM 682
            .||      ::..|.||| :...|:..|||........:::.|..|:||:.||..|...::...:
Mouse  1648 SSI------EDWEGEDLLVRSSELIHSGELTRVTQPQARSQQRMFFLFDRQLIYCKKDLLRRDVL 1706

  Fly   683 QYTYR-DSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLY-----------LKSEH 735
            .|..| |..:|....||.       |:|...       ..|.|.||.||           .:...
Mouse  1707 YYKGRLDMDDLEVVDVED-------GKDRDL-------HVSVKNAFRLYCGTTGDSHLLCARKPE 1757

  Fly   736 ERDKWRKALTEAMESL 751
            ::.:|.||.....|.:
Mouse  1758 QKQRWLKAFAREREQV 1773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	21/100 (21%)
		RhoGEF	428..603	CDD:279015	48/180 (27%)
		PH_Vav	624..753	CDD:269930	33/141 (23%)
		PH	641..749	CDD:278594	28/119 (24%)
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Arhgef4	NP_001355702.1	SH3_ASEF	1344..1416	CDD:212906	4/71 (6%)
		RhoGEF	1450..1631	CDD:238091	48/182 (26%)
		PH_Collybistin_ASEF	1637..1776	CDD:269931	36/157 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940