DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and FGD1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_004454.2	Gene:	FGD1 / 2245	HGNCID:	3663	Length:	961	Species:	Homo sapiens

Alignment Length:	786	Identity:	157/786 - (19%)
Similarity:	290/786 - (36%)	Gaps:	190/786 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 ASNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSS---SSLLVSESQRL---- 330
            :|.||:...|.:.|:   |:..|:.......:||||...::...:|.   ..|...|:.|.
Human   207 SSAAVSSLIEKFERE---PVIVASDRPVPGPSPGPPEPVMLPQPTSQPPVPQLPEGEASRCLFLL 268

  Fly   331 ---QRAAAAVYNYRS---SMASTEHEYAYIYSEDDEKVYEDLC---------YVTFQAKAKP--- 377
               .|....|.|..|   |::|..:.....:..||......||         .|......:|
Human   269 APGPRDGEKVPNRDSGIDSISSPSNSEETCFVSDDGPPSHSLCPGPPALASVPVALADPHRPGSQ 333

  Fly   378 EVTTDNIACNGTGYDHTNTKEEEVYQDL-CALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLD 441
            ||.:|        .:..:.:|||..:|. ..:....|.::...|..::..::..||:.||..|:.
Human   334 EVDSD--------LEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVS 390

  Fly   442 VLTALKTKFMGP-LERHLNQ-----DELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQ-- 498
            .|..|...|... ||...|:     |.:..||..|..:...|.:|       |.|..:.:|.:
Human   391 RLHLLDQVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQF-------LLPELEKRMEEWD 448

  Fly   499 ------VFLDFREPFL-IYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDIL 556
                  ..|....||| :|||:......|::.:....:::.....::.:.:::...|.|.|:..:
Human   449 RYPRIGDILQKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHM 513

  Fly   557 SVPMQRILKYHLLL-DKLVK--ETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVK 618
            ..|:|||.:|.||| |.|:|  ..||   |.:..:::.|.:...:::.|...|..:.:..:.||.
Human   514 LEPVQRIPRYELLLKDYLLKLPHGSP---DSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVY 575

  Fly   619 DSICDIHLLQNGNGSDLLQYGR-LLLDGELHIKAHEDQKTKLRYAFVF-DKILIMVKALHIKTGD 681
            :.:        |...|::...: |:.:|.:...:.::..|:.||..:| |::|..|..|.:.  .
Human   576 ELL--------GGEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLL--G 630

  Fly   682 MQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARK---SGK-TAFTLYLKSEHERDKWRK 742
            .:::.|...::....:::|.:             |.|.|.   ||| .:..|..::|.|:..|.:
Human   631 QKFSVRARIDVDGMELKESSN-------------LNLPRTFLVSGKQRSLELQARTEEEKKDWVQ 682

  Fly   743 ALTEAM----ESLE---------------PPGCQSTD---------HKMEI-------YTFDAPT 772
            |:...:    ::||               ||...:.|         .:.|:       ..|::.|
Human   683 AINSTLLKHEQTLETFKLLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSIT 747

  Fly   773 TCRH------------CSKFLKGRIHQGYR----CKVCQISVHKGCISSTGRCKQNPVSVPPPVC 821
            ..||            ||:|....::...|    |..|.:::| |...|:..|.|:.......:.
Human   748 KRRHHCKACGHVVCGKCSEFRARLVYDNNRSNRVCTDCYVALH-GVPGSSPACSQHTPQRRRSIL 811

  Fly   822 DRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQG----------PSTAHETMYALSLKTD 876
            ::|.|            .||   ||..|.::|..:...|          |......:|......|
Human   812 EKQAS------------VAA---ENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQD 861

  Fly   877 DNVIKHM-----KINQENSGDSMLYCLSSRRH-FKTIVELVSYYERNDLGENFAGLNQSLQWPYK 935
            ....:.:     ::....:|:.     ..||| ||.....:|:|        |:...:.||..:.
Human   862 VKAQRSLPLIGFEVGPPEAGER-----PDRRHVFKITQSHLSWY--------FSPETEELQRRWM 913

  Fly   936 EVIATA 941
            .|:..|
Human   914 AVLGRA 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	46/192 (24%)
		PH_Vav	624..753	CDD:269930	27/153 (18%)
		PH	641..749	CDD:278594	23/116 (20%)
		C1_1	761..804	CDD:278556	13/65 (20%)
		SH2_Vav_family	824..934	CDD:198193	23/125 (18%)
		SH3	940..993	CDD:302595	1/2 (50%)
FGD1	NP_004454.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..353		33/156 (21%)
		SH3-binding. /evidence=ECO:0000255	171..187
		RhoGEF	376..559	CDD:238091	46/192 (24%)
		PH1_FGD1	591..698	CDD:275392	25/121 (21%)
		PH	591..688	CDD:278594	23/111 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	702..726		3/23 (13%)
		FYVE_FGD1_2_4	725..789	CDD:277280	11/63 (17%)
		PH2_FGD1-4	815..920	CDD:270056	24/133 (18%)
		PH	823..921	CDD:278594	19/110 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	925..961
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910