DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Vav and Fgd4

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_001288746.1 Gene:Fgd4 / 224014 MGIID:2183747 Length:887 Species:Mus musculus


Alignment Length:817 Identity:151/817 - (18%)
Similarity:281/817 - (34%) Gaps:195/817 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 LLSDCQGSHVRELSFDLALDVVSS----TTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAAP 305
            |:|..:|..|.....||..|...:    .|.|.....:..|..:..| .||..............
Mouse   144 LISHFEGGSVLSSYIDLQKDSTMNLNIPQTLGQPGLTSSPPRKFLPQ-HSPQKQENDPDQTQGQH 207

  Fly   306 GPPMGRLVSTSS-----SSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYED 365
            |.....:|:..:     ......:|....:|.|||:...:            .:..|.:|.:.:.
Mouse   208 GCLANGVVAAQNQMECEDEKETTLSPEMAIQTAAASPDTH------------VLNGERNETITDS 260

  Fly   366 LCYVTFQAKAKPEVTTDNIACNGTGYD------------HTNTKEEEVYQDLCALHRTSRSQTAS 418
            ...:   |.:..|..:|: :|...|.|            ....:|.|...:...|....:.....
Mouse   261 ASSI---ANSHDENASDS-SCRTPGTDLGLPSKEGEPGMDAELQERENGVNTMGLDTLDQHHEVK 321

  Fly   419 STSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQ-----DELRLIFPRIRELVDIHT 478
            .|:.::...:..||:.||..|:..|..|...|...|....|:     :.:..||..|..:...|:
Mouse   322 ETNEQKLHKIATELLLTERAYVSRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHS 386

  Fly   479 KFLDKLRESLTPNAKVKMAQ--------VFLDFREPFL-IYGEFCSLLLGAIDYLADVCKKNQII 534
            ||       |.|..:.:|.:        ..|....||| :|||:......|::.:..:.::....
Mouse   387 KF-------LLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAVELVKTMTERVPQF 444

  Fly   535 DQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQ 599
            ..:.::.::....|.|.|:..:..|:|||.:|.:||...:|:.||...|:...:::.|.:...:.
Mouse   445 KSVTEEIQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPDSPDWNDAKKSLEIISTAAS 509

  Fly   600 YINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQ-YGRLLLDGELHIKAHEDQKTKLRYAF 663
            :.|...|..::|..:.::.:.:        |...|::. ...|:.:|::...|..:...:.||.|
Mouse   510 HSNSAIRKMENLKKLLEIYEML--------GEEEDIVNPSNELIKEGQILKLAARNTSAQERYLF 566

  Fly   664 VFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFT 728
            :|:.:|:.........|. ::|.|....:...::.::|:     .:....:|:     |||.. |
Mouse   567 LFNNMLLYCVPRFSLVGS-KFTVRTRVGIDGMKIVETHN-----EEYPHTFQI-----SGKER-T 619

  Fly   729 LYLKSEHERDK--WRKALTEAM-------ESLEPPGCQSTDHKMEIYTFD----AP--------T 772
            |.|::..|:||  |.|||.|::       |:......:..|..:|:.|.:    ||        |
Mouse   620 LELQASSEQDKEEWIKALQESIDAFHQRHETFRNAIAKENDIPLEVSTAELGKRAPRWIRDNEVT 684

  Fly   773 TCRHCSKFLKGRIHQGYRCKVC------QISVHKGCISSTGR-----CKQNPVSVPPPVCDRQLS 826
            .|..|.:.......:.:.|:.|      :.|.:|..:...|.     ||.         |.:.:|
Mouse   685 MCMKCKESFNALTRRRHHCRACGHVVCWKCSDYKAQLEYDGGRLNKVCKD---------CYQIIS 740

  Fly   827 EFNWFAGNMDRETAAHR----LENRRIG---------TYLLRVRP----------QGPST----- 863
            .|.      |.|....|    :|:..:.         .|:.:.:|          |.|..     
Mouse   741 GFT------DSEEKKRRGILEIESAEVSGNSEVCSFLQYMEKSKPWQKIWCVIPKQDPLVLYMYG 799

  Fly   864 ------AHETMYALSLKTDD-----NVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERN 917
                  |..|:..|....||     ::....|:.|..|..|                        
Mouse   800 APQDVRAQATIPLLGYVVDDMPKSADLPHSFKLTQSKSVHS------------------------ 840

  Fly   918 DLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQL 954
                 ||..|:.|:..:.::|..|:....|...|..|
Mouse   841 -----FAADNEELKQKWLKIILLAVTGETPDGPSEHL 872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015 42/188 (22%)
PH_Vav 624..753 CDD:269930 30/138 (22%)
PH 641..749 CDD:278594 27/116 (23%)
C1_1 761..804 CDD:278556 11/60 (18%)
SH2_Vav_family 824..934 CDD:198193 23/148 (16%)
SH3 940..993 CDD:302595 4/15 (27%)
Fgd4NP_001288746.1 RhoGEF 331..512 CDD:279015 42/187 (22%)
PH 544..641 CDD:278594 27/108 (25%)
PH1_FDG4 544..637 CDD:275434 24/104 (23%)
FYVE_FGD1_2_4 675..739 CDD:277280 12/72 (17%)
PH2_FGD1-4 758..860 CDD:270056 18/130 (14%)
PH 776..860 CDD:278594 17/112 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.