DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Fgd4

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001288746.1	Gene:	Fgd4 / 224014	MGIID:	2183747	Length:	887	Species:	Mus musculus

Alignment Length:	817	Identity:	151/817 - (18%)
Similarity:	281/817 - (34%)	Gaps:	195/817 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 LLSDCQGSHVRELSFDLALDVVSS----TTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAAP 305
            |:|..:|..|.....||..|...:    .|.|.....:..|..:..| .||..............
Mouse   144 LISHFEGGSVLSSYIDLQKDSTMNLNIPQTLGQPGLTSSPPRKFLPQ-HSPQKQENDPDQTQGQH 207

  Fly   306 GPPMGRLVSTSS-----SSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYED 365
            |.....:|:..:     ......:|....:|.|||:...:            .:..|.:|.:.:.
Mouse   208 GCLANGVVAAQNQMECEDEKETTLSPEMAIQTAAASPDTH------------VLNGERNETITDS 260

  Fly   366 LCYVTFQAKAKPEVTTDNIACNGTGYD------------HTNTKEEEVYQDLCALHRTSRSQTAS 418
            ...:   |.:..|..:|: :|...|.|            ....:|.|...:...|....:.....
Mouse   261 ASSI---ANSHDENASDS-SCRTPGTDLGLPSKEGEPGMDAELQERENGVNTMGLDTLDQHHEVK 321

  Fly   419 STSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQ-----DELRLIFPRIRELVDIHT 478
            .|:.::...:..||:.||..|:..|..|...|...|....|:     :.:..||..|..:...|:
Mouse   322 ETNEQKLHKIATELLLTERAYVSRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHS 386

  Fly   479 KFLDKLRESLTPNAKVKMAQ--------VFLDFREPFL-IYGEFCSLLLGAIDYLADVCKKNQII 534
            ||       |.|..:.:|.:        ..|....||| :|||:......|::.:..:.::....
Mouse   387 KF-------LLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAVELVKTMTERVPQF 444

  Fly   535 DQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQ 599
            ..:.::.::....|.|.|:..:..|:|||.:|.:||...:|:.||...|:...:::.|.:...:.
Mouse   445 KSVTEEIQKQKICGSLTLQHHMLEPIQRIPRYEMLLKDYLKKLSPDSPDWNDAKKSLEIISTAAS 509

  Fly   600 YINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQ-YGRLLLDGELHIKAHEDQKTKLRYAF 663
            :.|...|..::|..:.::.:.:        |...|::. ...|:.:|::...|..:...:.||.|
Mouse   510 HSNSAIRKMENLKKLLEIYEML--------GEEEDIVNPSNELIKEGQILKLAARNTSAQERYLF 566

  Fly   664 VFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFT 728
            :|:.:|:.........|. ::|.|....:...::.::|:     .:....:|:     |||.. |
Mouse   567 LFNNMLLYCVPRFSLVGS-KFTVRTRVGIDGMKIVETHN-----EEYPHTFQI-----SGKER-T 619

  Fly   729 LYLKSEHERDK--WRKALTEAM-------ESLEPPGCQSTDHKMEIYTFD----AP--------T 772
            |.|::..|:||  |.|||.|::       |:......:..|..:|:.|.:    ||        |
Mouse   620 LELQASSEQDKEEWIKALQESIDAFHQRHETFRNAIAKENDIPLEVSTAELGKRAPRWIRDNEVT 684

  Fly   773 TCRHCSKFLKGRIHQGYRCKVC------QISVHKGCISSTGR-----CKQNPVSVPPPVCDRQLS 826
            .|..|.:.......:.:.|:.|      :.|.:|..:...|.     ||.         |.:.:|
Mouse   685 MCMKCKESFNALTRRRHHCRACGHVVCWKCSDYKAQLEYDGGRLNKVCKD---------CYQIIS 740

  Fly   827 EFNWFAGNMDRETAAHR----LENRRIG---------TYLLRVRP----------QGPST----- 863
            .|.      |.|....|    :|:..:.         .|:.:.:|          |.|..
Mouse   741 GFT------DSEEKKRRGILEIESAEVSGNSEVCSFLQYMEKSKPWQKIWCVIPKQDPLVLYMYG 799

  Fly   864 ------AHETMYALSLKTDD-----NVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERN 917
                  |..|:..|....||     ::....|:.|..|..|
Mouse   800 APQDVRAQATIPLLGYVVDDMPKSADLPHSFKLTQSKSVHS------------------------ 840

  Fly   918 DLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQL 954
                 ||..|:.|:..:.::|..|:....|...|..|
Mouse   841 -----FAADNEELKQKWLKIILLAVTGETPDGPSEHL 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	42/188 (22%)
		PH_Vav	624..753	CDD:269930	30/138 (22%)
		PH	641..749	CDD:278594	27/116 (23%)
		C1_1	761..804	CDD:278556	11/60 (18%)
		SH2_Vav_family	824..934	CDD:198193	23/148 (16%)
		SH3	940..993	CDD:302595	4/15 (27%)
Fgd4	NP_001288746.1	RhoGEF	331..512	CDD:279015	42/187 (22%)
		PH	544..641	CDD:278594	27/108 (25%)
		PH1_FDG4	544..637	CDD:275434	24/104 (23%)
		FYVE_FGD1_2_4	675..739	CDD:277280	12/72 (17%)
		PH2_FGD1-4	758..860	CDD:270056	18/130 (14%)
		PH	776..860	CDD:278594	17/112 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910