DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Vav2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	XP_006497917.1	Gene:	Vav2 / 22325	MGIID:	102718	Length:	878	Species:	Mus musculus

Alignment Length:	1109	Identity:	278/1109 - (25%)
Similarity:	442/1109 - (39%)	Gaps:	372/1109 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQ 85
            ||:|..||..|||:||:|:...|.|.:..||..||||||||.|:.:|.|.|:|.::.|.:|||:|
Mouse     4 WRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDINFRPQMSQ 68

  Fly    86 FLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNL 150
            |||.|||:.||.|||:.||:|:::||:|..|:|:.:|.:|:..:|:||
Mouse    69 FLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLS----------------- 116

  Fly   151 QLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTED 215
                             |||.                       ....|.....|:.|.||
Mouse   117 -----------------LHSI-----------------------AQSKGIRPFPSEETAEN---- 137

  Fly   216 IDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPT 280
             ||.:..||..:.|.      .|.|.:   :.||
Mouse   138 -DDDVYRSLEELADE------HDLGED---IYDC------------------------------- 161

  Fly   281 PESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMA 345
                              ||.
Mouse   162 ------------------VPC-------------------------------------------- 164

  Fly   346 STEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHR 410
                      .::.:.:|||:..|                              ||.|.:...
Mouse   165 ----------EDEGDDIYEDIIKV------------------------------EVQQPMIRY-- 187

  Fly   411 TSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELVD 475
               .|....|..::|...:.|:.:||:.|...|..::..:||||...|:..::..:|..:.:|:.
Mouse   188 ---MQKMGMTEDDKRSCCLLEIQETEAKYYRTLEDIEKNYMGPLRLVLSPADMAAVFINLEDLIK 249

  Fly   476 IHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQK 540
            :|..||..:..|:...... :|:|||:|:|..|||||:||.:..|...|..:....:...|.|::
Mouse   250 VHHSFLRAIDVSMMAGGST-LAKVFLEFKERLLIYGEYCSHMEHAQSTLNQLLASREDFRQKVEE 313

  Fly   541 CERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVK 605
            |......||.:|:|:|.|||||:|||||||.:|:..::. ..:.:.|:.|.|||.|::.||||||
Mouse   314 CTLRVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAD-RPERQQLKEALEAMQDLAMYINEVK 377

  Fly   606 RDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILI 670
            ||.:.|   :|:.:..|.|..||    ..|.::||..:||||.:::..:...:.||.|:|||::|
Mouse   378 RDKETL---KKISEFQCSIENLQ----VKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVI 435

  Fly   671 MVKALHIKTGDMQYTYRDS-------HNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFT 728
            :.|    :.|   |:|...       |.:.|..:.....:::.|:  .:.|...|....||..|.
Mouse   436 VCK----RKG---YSYELKEVIELLFHKMTDDPMHNKDIKKSHGK--MWSYGFYLIHLQGKQGFQ 491

  Fly   729 LYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKV 793
            .:.|:|..:.||.:....||.:::|....:..|..::||||..|.|:.|..||:|..:|||.|..
Mouse   492 FFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQGYLCTR 556

  Fly   794 CQISVHKGCISSTGRCK---------------------QN------------------------- 812
            |.:..||.|:.....||                     ||
Mouse   557 CGVGAHKECLEVIPPCKMSSPADVDAPGAGPGPKMVAVQNYHGNPAPPGKPVLTFQTGDVIELLR 621

  Fly   813 ----------------------------------PVSVPPPVCDRQLSEFNWFAGNMDRETAAHR 843
                                              |.:..||..:...:.:.||||||:|:...:.
Mouse   622 GDPDSPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPTGRPPSREIDYTAYPWFAGNMERQQTDNL 686

  Fly   844 LENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIV 908
            |::...||||:|.||     |....:|:|:|.:|.| ||:|:.::   ||.:: ::..:.|::::
Mouse   687 LKSHASGTYLIRERP-----AEAERFAISIKFNDEV-KHIKVVEK---DSWIH-ITEAKKFESLL 741

  Fly   909 ELVSYYERNDLGENFAGLNQSLQWPYK-------------------------------------- 935
            |||.||:.:.|.|:|..|:.:|::|||
Mouse   742 ELVEYYQCHSLKESFKQLDTTLKFPYKSRERTTSRASSRSPASCASYNFSFLSPQGLSFAPQAPS 806

  Fly   936 ---------EVIATALYDYEPKA-GSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEY 990
                     .||.||:..|...| ...:|.||....|.:..:.|..:|||:|:....:|:||..|
Mouse   807 APFWSVFTPRVIGTAVARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKGETNGRIGWFPSTY 871

  Fly   991 VQEQ 994
            |:|:
Mouse   872 VEEE 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	55/110 (50%)
		RhoGEF	428..603	CDD:279015	60/174 (34%)
		PH_Vav	624..753	CDD:269930	35/135 (26%)
		PH	641..749	CDD:278594	28/114 (25%)
		C1_1	761..804	CDD:278556	19/42 (45%)
		SH2_Vav_family	824..934	CDD:198193	37/109 (34%)
		SH3	940..993	CDD:302595	18/53 (34%)
Vav2	XP_006497917.1	CAMSAP_CH	18..103	CDD:314792	44/84 (52%)
		RhoGEF	202..375	CDD:214619	60/174 (34%)
		PH_Vav	389..516	CDD:269930	36/139 (26%)
		C1	524..571	CDD:237996	19/46 (41%)
		SH3_VAV2_1	590..649	CDD:212913	2/58 (3%)
		SH2_Vav2	667..769	CDD:198269	39/111 (35%)
		SH3_VAV2_2	819..876	CDD:212910	19/57 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5031
eggNOG	1	0.900	-	-		E1_KOG2996
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1680
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52258
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001414
OrthoInspector	1	1.000	-	-		otm43078
orthoMCL	1	0.900	-	-		OOG6_103071
Panther	1	1.100	-	-	O	PTHR45818
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	1	1.000	-	-		X1295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860