DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Vav and Vav1

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_035821.3 Gene:Vav1 / 22324 MGIID:98923 Length:845 Species:Mus musculus


Alignment Length:1082 Identity:286/1082 - (26%)
Similarity:444/1082 - (41%) Gaps:351/1082 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 DLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQM 83
            :|||:|..||.:|:|:||.|:.....|::..||..||||||||.|:.:|.|.:::.||.|.:|||
Mouse     2 ELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLCQLLNNLLPQAINLREVNLRPQM 66

  Fly    84 AQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGF 148
            :||||.|||:.||..|...||::.::|||...|:|:.:|.:|:.|||.||.....|  :..::.|
Mouse    67 SQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQ--NKGIMPF 129

  Fly   149 NLQLSPTERSH-SDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENG 212
                 |||.|. :||.||..|                                            
Mouse   130 -----PTEDSALNDEDIYSGL-------------------------------------------- 145

  Fly   213 TEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAV 277
                .|.|:|:                                                      
Mouse   146 ----SDQIDDT------------------------------------------------------ 152

  Fly   278 TPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRS 342
                                                                             
Mouse   153 ----------------------------------------------------------------- 152

  Fly   343 SMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCA 407
                         :|:||.:|:  |....:|:.                       :|:|:||..
Mouse   153 -------------AEEDEDLYD--CVENEEAEG-----------------------DEIYEDLMR 179

  Fly   408 LHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRE 472
            |.  |.......|.:::|...:||:..||..|.|.|.:::..||.||:|.|...::..||..|.|
Mouse   180 LE--SVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVNIEE 242

  Fly   473 LVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQL 537
            |..:||.||.:|:::|.......:.|||:.::|.||:||.:||.:..|..:|..|....:.:...
Mouse   243 LFSVHTHFLKELKDALAGPGATTLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREDVQMK 307

  Fly   538 VQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYIN 602
            :::|.:..|.|:..|||:|.|||||:|||||||.:|||.|... .:..:|..|.:||.|::|.:|
Mouse   308 LEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDA-TEKENLRLALDAMRDLAQCVN 371

  Fly   603 EVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDK 667
            |||||::.|..|...:.||.::       ...|..|||..:||||.|.:.|.:....||||:.||
Mouse   372 EVKRDNETLRQITNFQLSIENL-------DQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDK 429

  Fly   668 ILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDT-RFKYQLLLARKSGKTAFTLYL 731
            .|::.|    :.|| .|..:.|.||..::|....|..   ||. ::.:..||....|...:.|:.
Mouse   430 ALLICK----RRGD-SYDLKASVNLHSFQVRDDSSGE---RDNKKWSHMFLLIEDQGAQGYELFF 486

  Fly   732 KSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQI 796
            |:...:.||.:....|:.::.|....:..|..::::|:..|:|:.|...|:|..:|||||..|:.
Mouse   487 KTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRA 551

  Fly   797 SVHKGCISSTGRC-----------------------KQNPV------------SVPPP------- 819
            ..||.|:.....|                       |:|.:            .:|||       
Mouse   552 PAHKECLGRVPPCGRHGQDFAGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGIPPPPGAFGPF 616

  Fly   820 ----------------------------------VCDR----------QLSEFNWFAGNMDRETA 840
                                              .|:|          .||...|:||.|:|..|
Mouse   617 LRLNPGDIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVHPYVHGPPQDLSVHLWYAGPMERAGA 681

  Fly   841 AHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNV-IKHMKINQENSGDSMLYCLSSRRHF 904
            ...|.||..||||:|.|.:  .||.   :|:|:|.  || :||:||.....    ||.::.::.|
Mouse   682 EGILTNRSDGTYLVRQRVK--DTAE---FAISIKY--NVEVKHIKIMTSEG----LYRITEKKAF 735

  Fly   905 KTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGS------------------ 951
            :.::|||.:|::|.|.:.|..|:.:||:||||....|:  .:|.|||                  
Mouse   736 RGLLELVEFYQQNSLKDCFKSLDTTLQFPYKEPERRAI--SKPPAGSTKYFGTAKARYDFCARDR 798

  Fly   952 NQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQE 993
            ::|.|:....:.::.|.| .:|||||:|...:|:||..||:|
Mouse   799 SELSLKEGDIIKILNKKG-QQGWWRGEIYGRIGWFPSNYVEE 839

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723 53/111 (48%)
RhoGEF 428..603 CDD:279015 66/174 (38%)
PH_Vav 624..753 CDD:269930 36/129 (28%)
PH 641..749 CDD:278594 32/108 (30%)
C1_1 761..804 CDD:278556 16/42 (38%)
SH2_Vav_family 824..934 CDD:198193 41/110 (37%)
SH3 940..993 CDD:302595 20/70 (29%)
Vav1NP_035821.3 CH 18..102 CDD:320720 39/83 (47%)
RhoGEF 195..371 CDD:238091 67/176 (38%)
PH_Vav 385..508 CDD:269930 38/137 (28%)
C1_1 516..567 CDD:278556 17/50 (34%)
SH3_VAV1_1 596..658 CDD:212912 5/61 (8%)
SH2_Vav1 665..767 CDD:198268 43/112 (38%)
SH3_VAV1_2 786..839 CDD:212909 15/53 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 133 1.000 Domainoid score I5031
eggNOG 1 0.900 - - E1_KOG2996
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3961
Inparanoid 1 1.050 435 1.000 Inparanoid score I1680
Isobase 1 0.950 - 0 Normalized mean entropy S4299
OMA 1 1.010 - - QHG52258
OrthoDB 1 1.010 - - D313065at33208
OrthoFinder 1 1.000 - - FOG0001414
OrthoInspector 1 1.000 - - otm43078
orthoMCL 1 0.900 - - OOG6_103071
Panther 1 1.100 - - LDO PTHR45818
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1291
SonicParanoid 1 1.000 - - X1295
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.820

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