DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and Vav1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_035821.3	Gene:	Vav1 / 22324	MGIID:	98923	Length:	845	Species:	Mus musculus

Alignment Length:	1082	Identity:	286/1082 - (26%)
Similarity:	444/1082 - (41%)	Gaps:	351/1082 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQM 83
            :|||:|..||.:|:|:||.|:.....|::..||..||||||||.|:.:|.|.:::.||.|.:|||
Mouse     2 ELWRQCTHWLIQCRVLPPSHRVTWEGAQVCELAQALRDGVLLCQLLNNLLPQAINLREVNLRPQM 66

  Fly    84 AQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGF 148
            :||||.|||:.||..|...||::.::|||...|:|:.:|.:|:.|||.||.....|  :..::.|
Mouse    67 SQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPIAQ--NKGIMPF 129

  Fly   149 NLQLSPTERSH-SDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENG 212
                 |||.|. :||.||..|
Mouse   130 -----PTEDSALNDEDIYSGL-------------------------------------------- 145

  Fly   213 TEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAV 277
                .|.|:|:
Mouse   146 ----SDQIDDT------------------------------------------------------ 152

  Fly   278 TPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRS 342

Mouse   153 ----------------------------------------------------------------- 152

  Fly   343 SMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCA 407
                         :|:||.:|:  |....:|:.                       :|:|:||..
Mouse   153 -------------AEEDEDLYD--CVENEEAEG-----------------------DEIYEDLMR 179

  Fly   408 LHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRE 472
            |.  |.......|.:::|...:||:..||..|.|.|.:::..||.||:|.|...::..||..|.|
Mouse   180 LE--SVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMKPLQRFLKPQDMETIFVNIEE 242

  Fly   473 LVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQL 537
            |..:||.||.:|:::|.......:.|||:.::|.||:||.:||.:..|..:|..|....:.:...
Mouse   243 LFSVHTHFLKELKDALAGPGATTLYQVFIKYKERFLVYGRYCSQVESASKHLDQVATAREDVQMK 307

  Fly   538 VQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYIN 602
            :::|.:..|.|:..|||:|.|||||:|||||||.:|||.|... .:..:|..|.:||.|::|.:|
Mouse   308 LEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDA-TEKENLRLALDAMRDLAQCVN 371

  Fly   603 EVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDK 667
            |||||::.|..|...:.||.::       ...|..|||..:||||.|.:.|.:....||||:.||
Mouse   372 EVKRDNETLRQITNFQLSIENL-------DQSLANYGRPKIDGELKITSVERRSKTDRYAFLLDK 429

  Fly   668 ILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDT-RFKYQLLLARKSGKTAFTLYL 731
            .|::.|    :.|| .|..:.|.||..::|....|..   ||. ::.:..||....|...:.|:.
Mouse   430 ALLICK----RRGD-SYDLKASVNLHSFQVRDDSSGE---RDNKKWSHMFLLIEDQGAQGYELFF 486

  Fly   732 KSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQI 796
            |:...:.||.:....|:.::.|....:..|..::::|:..|:|:.|...|:|..:|||||..|:.
Mouse   487 KTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRGTFYQGYRCYRCRA 551

  Fly   797 SVHKGCISSTGRC-----------------------KQNPV------------SVPPP------- 819
            ..||.|:.....|                       |:|.:            .:|||
Mouse   552 PAHKECLGRVPPCGRHGQDFAGTMKKDKLHRRAQDKKRNELGLPKMEVFQEYYGIPPPPGAFGPF 616

  Fly   820 ----------------------------------VCDR----------QLSEFNWFAGNMDRETA 840
                                              .|:|          .||...|:||.|:|..|
Mouse   617 LRLNPGDIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVHPYVHGPPQDLSVHLWYAGPMERAGA 681

  Fly   841 AHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNV-IKHMKINQENSGDSMLYCLSSRRHF 904
            ...|.||..||||:|.|.:  .||.   :|:|:|.  || :||:||.....    ||.::.::.|
Mouse   682 EGILTNRSDGTYLVRQRVK--DTAE---FAISIKY--NVEVKHIKIMTSEG----LYRITEKKAF 735

  Fly   905 KTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGS------------------ 951
            :.::|||.:|::|.|.:.|..|:.:||:||||....|:  .:|.|||
Mouse   736 RGLLELVEFYQQNSLKDCFKSLDTTLQFPYKEPERRAI--SKPPAGSTKYFGTAKARYDFCARDR 798

  Fly   952 NQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQE 993
            ::|.|:....:.::.|.| .:|||||:|...:|:||..||:|
Mouse   799 SELSLKEGDIIKILNKKG-QQGWWRGEIYGRIGWFPSNYVEE 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	53/111 (48%)
		RhoGEF	428..603	CDD:279015	66/174 (38%)
		PH_Vav	624..753	CDD:269930	36/129 (28%)
		PH	641..749	CDD:278594	32/108 (30%)
		C1_1	761..804	CDD:278556	16/42 (38%)
		SH2_Vav_family	824..934	CDD:198193	41/110 (37%)
		SH3	940..993	CDD:302595	20/70 (29%)
Vav1	NP_035821.3	CH	18..102	CDD:320720	39/83 (47%)
		RhoGEF	195..371	CDD:238091	67/176 (38%)
		PH_Vav	385..508	CDD:269930	38/137 (28%)
		C1_1	516..567	CDD:278556	17/50 (34%)
		SH3_VAV1_1	596..658	CDD:212912	5/61 (8%)
		SH2_Vav1	665..767	CDD:198268	43/112 (38%)
		SH3_VAV1_2	786..839	CDD:212909	15/53 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5031
eggNOG	1	0.900	-	-		E1_KOG2996
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3961
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1680
Isobase	1	0.950	-	0	Normalized mean entropy	S4299
OMA	1	1.010	-	-		QHG52258
OrthoDB	1	1.010	-	-		D313065at33208
OrthoFinder	1	1.000	-	-		FOG0001414
OrthoInspector	1	1.000	-	-		otm43078
orthoMCL	1	0.900	-	-		OOG6_103071
Panther	1	1.100	-	-	LDO	PTHR45818
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	1	1.000	-	-		X1295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.820