DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and SPATA13

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001273721.1	Gene:	SPATA13 / 221178	HGNCID:	23222	Length:	1339	Species:	Homo sapiens

Alignment Length:	860	Identity:	198/860 - (23%)
Similarity:	323/860 - (37%)	Gaps:	239/860 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 CHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEA 163
            ||:|                    |..|...|:.|:.|..:....:....:|| .|.|.:|.||.
Human   549 CHSN--------------------HSALSANSEESEGRAEEPAQREPGPVSLQ-DPLEATHGDEG 592

  Fly   164 IYKDLHST-----------------DLNMRKTSSIDASASSS-------------------AEYY 192
             .|||...                 |...|::||.|...:.:                   ::|.
Human   593 -SKDLLVNIGVAAGPEEKEKEEVVPDGPWRRSSSQDEERTEAQRTPKRRWGSGRRPRPRPFSDYG 656

  Fly   193 DRTSQSGSLDENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVREL 257
            ...|:|.|:.|:| :..:...||..|  ||..::|..::.::  ::|.|..|     :|:..|.
Human   657 QLASRSLSIPEDS-VAADPQKEDRVD--EDPQASMTSASPED--QNAPVGCP-----KGARRRR- 710

  Fly   258 SFDLALDVV-------SSTTDGASNAVT------PTPESYARQSQSPLAAAAPSVPVSAAPGPPM 309
                .:.|:       ::.|:...|.:|      |.|   |.|.....|.:|...|.:.:...|:
Human   711 ----PISVIGGVSLYGTNQTEELDNLLTQPASRPPMP---AHQVPPYKAVSARFRPFTFSQSTPI 768

  Fly   310 GRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYI---YSEDDEKVYEDLCYVTF 371
            |            |....:|.|..|:.|    ||...||.. |.:   .||:|.. |||||
Human   769 G------------LDRVGRRRQMRASNV----SSDGGTEPS-ALVDDNGSEEDFS-YEDLC---- 811

  Fly   372 QAKAKP-------------EVTTD-NIACNGTGYDHTNTKEEE-------VYQDLCA-------- 407
              :|.|             |:.:| |:.|....:||....::|       |.|.|.|
Human   812 --QASPRYLQPGGEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWG 874

  Fly   408 -----------------LHRTSRSQTASSTSFEQRD-------------------YVIRELIDTE 436
                             :::...|:.:|||..|::|                   .||||::|||
Human   875 RSEDKEAWFPASFVRLRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTE 939

  Fly   437 SNYLDVLTALKTKFMGPLERHLNQ---DELRLIFPRIRELVDIHTKFLDKLRESLT---PNAKVK 495
            ..|:..|..:...::....:|...   .:|..||..|.::.....|||..|.:...   |:.. :
Human   940 RVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLS-E 1003

  Fly   496 MAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKN---------QIIDQLVQKCERDYNVGKLQ 551
            :...||..:|.|.||.|:|:...||...||::.|:.         :::.|::.          :.
Human  1004 IGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMID----------IA 1058

  Fly   552 LRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQK 616
            :...|..|:|:|.||.|.|.:|:|.|:..|.||.:::.|.|||.:|:..|||.||..:.:..|.:
Human  1059 IDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIAR 1123

  Fly   617 VKDSICDIHLLQNGNGSDLL-QYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTG 680
            .:.||.      ...|.|:| :...|:..||| .|..:..|::.|..|:||..|:..|...::..
Human  1124 WQVSIV------GWEGLDILDRSSELIHSGEL-TKITKQGKSQQRTFFLFDHQLVSCKKDLLRRD 1181

  Fly   681 DMQYTYR---DSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARK-SGKTAFTLYL---KSEHERD 738
            .:.|..|   |...|.|.         ..|||......:..|.| ..:|...:||   |.:.::.
Human  1182 MLYYKGRLDMDEMELVDL---------GDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKA 1237

  Fly   739 KWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGY-RCKVCQISVHKGC 802
            :|.:|..:....::    :..:..|||..........:..|...|: .:|| ||.|.  ..|:|.
Human  1238 RWLQACADERRRVQ----EDKEMGMEISENQKKLAMLNAQKAGHGK-SKGYNRCPVA--PPHQGL 1295

  Fly   803 ISSTGRCKQNPVSVP 817
            .....|....|.|||
Human  1296 HPIHQRHITMPTSVP 1310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	6/32 (19%)
		RhoGEF	428..603	CDD:279015	53/189 (28%)
		PH_Vav	624..753	CDD:269930	31/136 (23%)
		PH	641..749	CDD:278594	28/114 (25%)
		C1_1	761..804	CDD:278556	12/43 (28%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
SPATA13	NP_001273721.1	SH3_ASEF	821..892	CDD:212906	11/70 (16%)
		RhoGEF	931..1110	CDD:279015	53/189 (28%)
		PH_Collybistin_ASEF	1115..1253	CDD:269931	34/157 (22%)
		PH	1143..1242	CDD:278594	27/108 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1291
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940