DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Tiam1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001139358.1	Gene:	Tiam1 / 21844	MGIID:	103306	Length:	1591	Species:	Mus musculus

Alignment Length:	936	Identity:	184/936 - (19%)
Similarity:	312/936 - (33%)	Gaps:	322/936 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 EAIYKDLH-----STDLNMRKTSSIDASASSSAEYYDRTSQSG-------SLDENSDITIENGTE 214
            |.:||::.     :.::::.|:   ||:|.:.........:.|       |:.| :.:..:.|.:
Mouse   830 ELLYKEIEICPKVTQNIHIEKS---DAAADNYGFLLSSVDEDGIRRLYVNSVKE-TGLASKKGLK 890

  Fly   215 DIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASNAVTP 279
            ..|:.:|          |:|.|  ||.               |:..:..|.:|..:.|......|
Mouse   891 AGDEILE----------INNRA--AGT---------------LNSSMLKDFLSQPSLGLLVRTYP 928

  Fly   280 TPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSM 344
            .||......::|.......|.:..:|      |...:|:....|.||    |.::|       ..
Mouse   929 EPEGGVELLENPPHRVDGPVDLGESP------LAFLTSNPGHSLSSE----QGSSA-------ET 976

  Fly   345 ASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALH 409
            |..|.|...:.|.|:.                               ||::...|:|.....:||
Mouse   977 APEEGEGPDLESSDET-------------------------------DHSSKSTEQVAAFCRSLH 1010

  Fly   410 RTSRS------------QTASSTSFEQRD---YVIRELIDTESNYLDVLTALKTKFMGPLERH-- 457
            ..|.|            |.|::......|   .||.||::||..|:..|..|..:::.||::.
Mouse  1011 EMSPSDSSPSPQDATSPQLATTRQLSDADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETF 1075

  Fly   458 LNQDELRLIFPRIRELVDIHTKFLDKLRES--LTPNAKVKMAQV-------------FLDFREPF 507
            |.||||.::|..:.|:|:...:||..|.:.  |.|:.: |:.:|             ||.:.:.|
Mouse  1076 LTQDELDVLFGNLTEMVEFQVEFLKTLEDGVRLVPDLE-KLEKVDQFKKVLFSLGGSFLYYADRF 1139

  Fly   508 LIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERD------------YNVGKLQLRDILSVPM 560
            .:|..||:              .:..:.:::.|.:.|            .......|...|..|:
Mouse  1140 KLYSAFCA--------------SHTKVPKVLVKAKTDTAFKAFLDAQNPRQQHSSTLESYLIKPI 1190

  Fly   561 QRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDS-------DHLVIIQK-V 617
            ||:|||.|||.:|...|....:::..|:.|.:.|..|:.:|||:::..       |.|:..|. .
Mouse  1191 QRVLKYPLLLRELFALTDAESEEHYHLDVAIKTMNKVASHINEMQKIHEEFGAVFDQLIAEQTGE 1255

  Fly   618 KDSICDIHLLQNGNGSDLLQY------------GRLLLDGELHIKAHEDQKTKLRYAFVFDKILI 670
            |..:.|:.:      .|||.:            |:...:.||             .||||...::
Mouse  1256 KKEVADLSM------GDLLLHTSVIWLNPPASLGKWKKEPEL-------------AAFVFKTAVV 1301

  Fly   671 MVKALHIKTGDMQYTYRD----------SHNLADYR----------------------------- 696
            :|             |:|          ||.|:.|.
Mouse  1302 LV-------------YKDGSKQKKKLVGSHRLSIYEEWDPFRFRHMIPTEALQVRALPSADAEAN 1353

  Fly   697 --VEQSHSR-RTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHE--RDKWRKALTEAMESLEPPGC 756
              .|..|.: .:.||..|..:....:.:|.|.    :|||.|.  |||.|:.|.:. |||  |..
Mouse  1354 AVCEIVHVKSESEGRPERVFHLCCSSPESRKD----FLKSVHSILRDKHRRQLLKT-ESL--PSA 1411

  Fly   757 QSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVC 821
            |      :...|.....|.     |||                                 ..|..
Mouse  1412 Q------QYVPFGGKRLCA-----LKG---------------------------------ARPAM 1432

  Fly   822 DRQLSEFNWFAGNMDRETAAHR--LENRRIGTYLLRVRPQGPSTAHET------MYALS------ 872
            .|.:|..:...|...|..|.:|  :::..|........||.|:...:|      .:.|:
Mouse  1433 SRAVSAPSKSLGRRRRRLARNRFTIDSDAISASSPEKEPQQPAGGGDTDRWVEEQFDLAQYEEQD 1497

  Fly   873 -------LKTDDNVIKHMK---INQENSGDSMLYCLSSR-RHFKTIVELVSYYERNDLGENFAGL 926
                   |..||...:.:|   ::::.........:|.| |..:|:....|...:.......:|:
Mouse  1498 DIKETDILSDDDEFCESLKGASVDRDLQEQLQAASISQRARGRRTLDSHASRMTQLKKQAALSGI 1562

  Fly   927 NQSLQWPYKEVIATALYDYEPKAGSN 952
            |..|:...:|||.....|:.|....|
Mouse  1563 NGGLESASEEVIWVRREDFAPSRKLN 1588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	52/203 (26%)
		PH_Vav	624..753	CDD:269930	36/184 (20%)
		PH	641..749	CDD:278594	29/151 (19%)
		C1_1	761..804	CDD:278556	5/42 (12%)
		SH2_Vav_family	824..934	CDD:198193	23/134 (17%)
		SH3	940..993	CDD:302595	3/13 (23%)
Tiam1	NP_001139358.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..380
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..422
		PH1_Tiam1_2	432..558	CDD:269937
		Tiam_CC_Ex	572..669	CDD:408184
		RBD	766..832	CDD:128731	1/1 (100%)
		PDZ_signaling	846..925	CDD:238492	19/109 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	933..1034		25/148 (17%)
		RhoGEF	1044..1233	CDD:214619	52/203 (26%)
		PH2_Tiam1_2	1235..1406	CDD:269957	38/207 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1456..1481		4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910