DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and Stac2

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_666140.1 Gene:Stac2 / 217154 MGIID:2144518 Length:408 Species:Mus musculus


Alignment Length:335 Identity:87/335 - (25%)
Similarity:131/335 - (39%) Gaps:76/335 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   711 RFKYQLLLAR-KSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPG--CQSTD------------ 760
            |||..|.|.. ...|:....:|:|..|.....:.|......|.||.  ..|||            
Mouse    33 RFKRSLSLKTILRSKSVENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPASTDRGLPTPTPSPCP 97

  Fly   761 -------------HKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGC---------- 802
                         |..:.:.|...:.|..|.:.:.|...||.|||.|::|||..|          
Mouse    98 VPRPLAPLKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKTCKVSVHLWCSEEISHQQCP 162

  Fly   803 ---ISSTGRCKQNP--VSVPPPVCD-RQLSEFNWFAGNMDRETAAHRLENRRIGTYL-LRVRPQG 860
               .:|..|...:|  |..|||.|. .:.|.....:|.:|..     .|..|.||.| |..|...
Mouse   163 GKTSTSFRRNFSSPLLVHAPPPACAMNKESPPTGTSGKVDPV-----YETLRYGTSLALMNRSSF 222

  Fly   861 PSTAHETMYALSLK---TDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGEN 922
            .||:.....:||.:   |:|.. ..::.::|..|||:         |....|    .|.:...|.
Mouse   223 SSTSESPTRSLSERDELTEDGE-GSIRSSEEGPGDSV---------FTAPAE----SEGSGPEEK 273

  Fly   923 FAGLNQSLQWPYKEVIA-----TALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDT 982
            ..| .|..:.|.::.:.     .|||.:.|:. :|.|.|:...:::::  |..::.||:|||||.
Mouse   274 SPG-QQPPKLPLRKDVGPMYSYVALYKFLPQE-NNDLALQPGDRIMLV--DDSNEDWWKGKIGDR 334

  Fly   983 VGYFPKEYVQ 992
            ||:||..:||
Mouse   335 VGFFPANFVQ 344

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015
PH_Vav 624..753 CDD:269930 11/42 (26%)
PH 641..749 CDD:278594 10/38 (26%)
C1_1 761..804 CDD:278556 15/55 (27%)
SH2_Vav_family 824..934 CDD:198193 26/113 (23%)
SH3 940..993 CDD:302595 21/53 (40%)
Stac2NP_666140.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..29
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 64..97 7/32 (22%)
C1 111..161 CDD:237996 15/49 (31%)
STAC2_u1 167..292 CDD:293269 35/144 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..286 18/81 (22%)
SH3_Stac2_C 293..345 CDD:212918 21/55 (38%)
SH3 352..403 CDD:302595
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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