Protein Alignment Vav and Plekhg1

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_006512502.1
• Gene: Plekhg1 / 213783
• MGIID: 2676551
• Length: 1487
• Species: Mus musculus
• Alignment Length: 564
• Identity: 139/564 - (24%)
• Similarity: 245/564 - (43%)
• Gaps: 113/564 - (20%)

  Fly   261 LALDVVSSTTDGASNAVTPTPESYARQSQSP----LAAAAPSVPVSAAPGPPMGRLVSTSSSSSS 321
            |.|||.|:.      ::.|.|.:.|..|:||    :..:....|:|..         |||||:||
Mouse    69 LQLDVPSAV------SLVPDPRTTAEPSESPEPKTMELSDSDRPISFG---------STSSSASS 118

  Fly   322 LLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIAC 386
                      |.:...:..|.::.|..|  ..::.:|.|.....|..|..:..:..|:..|..|
Mouse   119 ----------RDSHGSFGSRMTLVSNSH--LGLFHQDKEAGAIKLELVPARPFSSSELQRDKPA- 170

  Fly   387 NGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQR----DYVIRELIDTESNYLDVLTALK 447
               |..:.|...|:..:....:..:...||.:.::...:    |.|::|:::||..|:.   .||
Mouse   171 ---GPQNMNGVSEKQPRTPWRMDTSGTPQTTADSATSPKLLYVDRVVQEILETERTYVQ---DLK 229

  Fly   448 TKFMGPLERHLNQDELRLI-------FPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFRE 505
            :...|.||...:|.:|.|:       |..|:::...:::.|..|..  ..|..|.:|:.|:...|
Mouse   230 SIVEGYLECIRDQTKLPLVTEDRAALFGNIQDIYHFNSELLQDLEN--CENDPVAIAECFVSKSE 292

  Fly   506 PFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNV-GKLQLRDILSVPMQRILKYHLL 569
            .|.||.::|:....::..|.: |.:|:|:.:..:  ||...: ..|.|...|..|:|||||||||
Mouse   293 EFHIYTQYCTNYPRSVAVLTE-CMRNKILTKFFR--ERQETLRHSLPLGSYLLKPVQRILKYHLL 354

  Fly   570 LDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSD 634
            |.::........:.|..:..|.:.|..|:.:||::||..:|.|.:|:::.      ||.|..|.|
Mouse   355 LHEIENHLDKATEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQS------LLTNWEGPD 413

  Fly   635 LLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLAD--YRV 697
            |..||.|:|:|...|:..:.::|    .|:.|::|::.     |..|..:||: :|.|..  ..|
Mouse   414 LTSYGELVLEGTFRIQKAKKERT----LFLLDQLLLIT-----KKRDDTFTYK-AHILCGNLMLV 468

  Fly   698 EQSHSRRTIGRD----TRFKYQLLLARKSGKTAFTLYLKSEHERDKW------------------ 740
            |      .|.::    :.|.|      |:.|...|:..||:.::..|
Mouse   469 E------VIPKEPLSFSVFHY------KNPKLQHTVQAKSQQDKRLWVLHLKRLILENHAAAAKI 521

  Fly   741 ----RKALTEAMESLEPPG-CQSTDHKMEIYTFDAPTTCRHCSK 779
                ::|:.| |:::..|| |.|.:.:|:.....||...|..|:
Mouse   522 PAKAKQAILE-MDAIHYPGFCYSPEGEMKTPCGSAPHRLRRKSE 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050
		RhoGEF	428..602	CDD:459876	50/181 (28%)
		PH_Vav	624..753	CDD:269930	36/156 (23%)
		C1_VAV	759..810	CDD:410360	5/21 (24%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:473055
Plekhg1	XP_006512502.1	RhoGEF	213..387	CDD:459876	50/181 (28%)
		PH_PLEKHG1_G2_G3	369..514	CDD:270063	44/172 (26%)