DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and Stac

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_058549.1	Gene:	Stac / 20840	MGIID:	1201400	Length:	403	Species:	Mus musculus

Alignment Length:	273	Identity:	59/273 - (21%)
Similarity:	99/273 - (36%)	Gaps:	67/273 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   754 PGCQSTDHKMEIYTFDAPTTCRHCSKFLKG-RIHQGYRCKVCQISVHKGCISSTG--RCK----- 810
            ||..|..|..:.:.|..||.|..|:..:.| ....|.||..|::|:|..|.....  ||.
Mouse   102 PGSNSKLHAFQEHVFKKPTFCDVCNHMIVGTHAKHGLRCGACKMSIHHKCADGLAPQRCMGKLPK 166

  Fly   811 ------QNPV----------SVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLL-RVRP 858
                  .:|:          .|.|..|..::...               .|..|.||.|. |.:.
Mouse   167 GFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPV---------------YEALRFGTSLAQRTKK 216

  Fly   859 QGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGE-- 921
            .|..:..::    ..:|..:.:..:....:..||.        ...:|....|..|..|.:.:
Mouse   217 GGSGSGSDS----PPRTSTSELVDVPEEADGPGDG--------SDMRTRSNSVFTYPENGMDDFR 269

  Fly   922 ------NFAG-LNQSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSKGWWRGKI 979
                  |..| |::.   |.:.....|||.:.|:. :..|::|....:.::  :..::.||:|||
Mouse   270 DQMKTTNHQGPLSKD---PLQMNTYVALYRFIPQE-NEDLEMRPGDMITLL--EDSNEDWWKGKI 328

  Fly   980 GDTVGYFPKEYVQ 992
            .|.||:||..:||
Mouse   329 QDRVGFFPANFVQ 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556	14/43 (33%)
		SH2_Vav_family	824..934	CDD:198193	17/119 (14%)
		SH3	940..993	CDD:302595	18/53 (34%)
Stac	NP_058549.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		C1	109..160	CDD:237996	14/50 (28%)
		STAC2_u1	167..>262	CDD:293269	17/121 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..264		8/63 (13%)
		SH3_Stac_1	290..342	CDD:212767	18/55 (33%)
		SH3	349..399	CDD:302595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910