Protein Alignment Vav and Rasgrf2

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: XP_036013814.1
• Gene: Rasgrf2 / 19418
• MGIID: 109137
• Length: 1190
• Species: Mus musculus
• Alignment Length: 564
• Identity: 124/564 - (21%)
• Similarity: 232/564 - (41%)
• Gaps: 139/564 - (24%)

  Fly   317 SSSSSLLVSESQRLQRAAAAVYNYRSSMASTE--------HEYAYIYSEDDEKVYEDLCYVTFQA 373
            :|.:.:|:.....:|:     |.:...:..||        |:.     ||.:...|.|
Mouse   131 ASYADILIEREVLMQK-----YIHLVQIVETEKIATNQLRHQL-----EDQDTEIERL------- 178

  Fly   374 KAKPEVTTDNIACNGT-----GYDHTNTKEEE------------------------VYQD-LCAL 408
              |.|:    :|.|.|     .| |.:.:||:                        :.|| :|:.
Mouse   179 --KSEI----VALNKTKERMRPY-HVHQEEEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSP 236

  Fly   409 HRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPL-------ERHLNQDELRLI 466
            |         :.|..:|:.::..:::.|:.|:..|..|...|:.||       :..:|.|::..|
Mouse   237 H---------AESMRKRNQIVFTMVEAETEYVHQLYILVNGFLRPLRMAASSKKPPINHDDVSSI 292

  Fly   467 FPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFL-IYGEFCSLLLGAIDYLADVCKK 530
            |.....::.:|..|...|:..|.....:.:|.:| |...|.| ||.||......::..||: ||:
Mouse   293 FLNSETIMFLHEIFHQGLKARLANWPTLVLADLF-DILLPMLNIYQEFVRNHQYSLQVLAN-CKQ 355

  Fly   531 NQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMI 595
            |:..|:|:::.|.:.......|...|:.||.:|.:|.:.|.:|:..|...|.:.:|||.||..:.
Mouse   356 NRDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLE 420

  Fly   596 DVSQYINEVKRDSDHL---VIIQKVKDSICDIHL------LQNGNGSDLLQY-----GRL--LLD 644
            ::|:.:::...|::::   :.|:::....|||.|      ::.|:   |:|.     |:|  :..
Mouse   421 ELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGS---LIQVPSVERGKLSKVRL 482

  Fly   645 GELHIKAHEDQKTKLRYAFVFDK-ILIMVKA----LH-IKTGD----MQYTYRDSHNLADYRVEQ 699
            |.|.:|     |...|..|:|.| .||..::    || :|||.    :|.|..:..:.:|  .:.
Mouse   483 GSLSLK-----KEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIQCTLIEEPDGSD--DDP 540

  Fly   700 SHSRRTIGRDTRFKYQLLLARKSGKTAFTLYL--KSEHERDKWRKALTEAMESLEPPGCQSTDHK 762
            ..|....|. ..||   ::.......:||:.|  .|..|:..|...:::.::::...|..:.
Mouse   541 KGSGHMFGH-LDFK---IVVEPPDAASFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTI--- 598

  Fly   763 MEIYTFDAPTTCRHCSKFLKGRIHQG----------YRCKVCQI 796
              ::..::..|..|..| ...|:|:.          ..|||.||
Mouse   599 --VFEENSKVTVPHMIK-SDARLHKDDTDICFSKTLNSCKVPQI 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/182 (26%)
		PH_Vav	624..753	CDD:269930	35/153 (23%)
		PH	641..749	CDD:278594	29/121 (24%)
		C1_1	761..804	CDD:278556	10/46 (22%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
Rasgrf2	XP_036013814.1	PH_RasGRF1_2	19..158	CDD:270081	5/31 (16%)
		RhoGEF	247..428	CDD:214619	48/182 (26%)
		PH	480..588	CDD:214574	28/118 (24%)
		RasGEF_N	638..>686	CDD:395493	2/2 (100%)
		REM	<853..925	CDD:413353
		RasGEF	951..1187	CDD:214539

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910