DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and frm-3

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001361874.1	Gene:	frm-3 / 186110	WormBaseID:	WBGene00001490	Length:	1091	Species:	Caenorhabditis elegans

Alignment Length:	500	Identity:	94/500 - (18%)
Similarity:	168/500 - (33%)	Gaps:	159/500 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 PTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDENSDITIENGTEDIDD 218
            |..|:.:...|..|..:.||:.|::.:  |:.:::..|.:.|:   ::...|.:...:|.
Worm   616 PFARNANIVPIEIDGPNVDLSARRSPA--ATTTTTRTYANTTT---TVTTTSKVLTSSGA----- 670

  Fly   219 YIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGA-----SNAVT 278
                  ..|....|.||.|.:          .|:|...:|       ..|.|.||     ...:|
Worm   671 ------VLMKPKVISNDHEPS----------SGTHSSRVS-------PESGTYGALGPLPGRVIT 712

  Fly   279 P-----TPESYARQSQSPLAAAAPSVPVSAAPG-PPMGRLVSTSSSSSSLLVSESQRLQRAAAAV 337
            .     |||.:..:...|.....||.||.|... ..:.|.:.|..:||..||...:.:..:.|.:
Worm   713 KENMMITPEGFKEKKAKPNPPPKPSFPVQAVHSETEVVREIKTERASSHPLVHMQEEIPFSRAPL 777

  Fly   338 -YNYRSSMASTEHEYAYI--YSEDDEKVYEDLCYVTFQAKAKPEVTTDNI----ACNGTGYDHTN 395
             :..:....|:....|.|  .|||:..|.:  |:: |.:.....:|..|:    :...:.:...:
Worm   778 KFEDKKERKSSLSRPALISVQSEDNPDVQK--CHL-FNSDIPYTLTMRNVENTQSLPYSSFKDVS 839

  Fly   396 TKEEEVYQDLCALHRTSRSQTASSTSFEQR---DYVIRELIDTESNY-------------LDVLT 444
            |.:::.|:.      .|..:.:.|..|::|   |.|.|:.:.:..|:             .|||.
Worm   840 TAKKQGYES------NSLKRVSKSPEFKRRKSLDLVPRKRLPSPGNFSAQDHTISPTTPDSDVLE 898

  Fly   445 ALKTKFMGPLERHLNQDELRLIFPRIRELVDIHTKFLDKLRES------LTPNAKVKMAQVFLDF 503
            .|..:      |.|..|         :.::...:|..|..|::      |.|:.
Worm   899 YLLRR------RSLLGD---------KSVIKTKSKRTDPRRQTQPVRFDLPPSP----------- 937

  Fly   504 REPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHL 568
                      ||...|.                                    |.|...||...
Worm   938 ----------CSPTAGG------------------------------------STPFISILNDD- 955

  Fly   569 LLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKR----DSD 609
            |.|:.|.|:..||:|...|::.......:|.::::..|    |||
Worm   956 LFDECVSESRSLHEDMDRLDKTTPHNQSISSFMSQKSRRDSEDSD 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	31/193 (16%)
		PH_Vav	624..753	CDD:269930
		PH	641..749	CDD:278594
		C1_1	761..804	CDD:278556
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
frm-3	NP_001361874.1	B41	26..219	CDD:214604
		FERM_C_FARP1-like	206..327	CDD:270014
		FA	320..>353	CDD:370090
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910