DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and pix-1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001257227.1	Gene:	pix-1 / 181490	WormBaseID:	WBGene00010776	Length:	646	Species:	Caenorhabditis elegans

Alignment Length:	721	Identity:	127/721 - (17%)
Similarity:	260/721 - (36%)	Gaps:	185/721 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   343 SMASTEHEYAYIYSEDDEKVY--EDLCYVTFQA-----KAKPEVTTDNIACNGTGYDHTNTKEEE 400
            |..|...::.:..|.:||..:  :|:..:|.|.     :...|..|....|   .|....|::::
Worm     7 SPLSARAKFQFEGSNNDELSFDKDDIITITQQQEGGWWEGTHEGVTGWFPC---AYVTLITEKDK 68

  Fly   401 VYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPL--ERHLNQDEL 463
            :.:.....:.|::...:.....:.||.|::..|::|..|:..|.......:.|:  .:.|...|.
Worm    69 LQRSRSVPNATAKEVVSVGAQPDYRDLVLKSYIESEKEYMQSLLKTLQSLLIPIGASKILTAPEY 133

  Fly   464 RLIFPRIRELVDIHTKFLDKL-RESLTPNAKVKMAQVF----LDFREPFLIYGEFCSLLLGAIDY 523
            ..:......:..:.....::| ||......|:::..:|    |:.|...:.|.:      ...|.
Worm   134 CTLVGNFEVIYTLKRDLFEQLEREQNEELPKMRVGGMFMNAALELRTALMSYAD------NHPDA 192

  Fly   524 LADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLE 588
            :..:.||.:.::::|:..:|:|.  :|.|.  ||.|::.:.:|:.||.:|.:.....|.|...|:
Worm   193 VEVLKKKQKELEKVVKSQDREYK--ELVLG--LSEPLRHVERYYNLLQELERIVPANHPDRGDLQ 253

  Fly   589 RAKEAM---IDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIK 650
            |.....   .|:.:.:.:.|......:.:.|| |.:....           :.|.:|..|..:::
Worm   254 RGSAVFRETKDLCETLRKQKEAQLDFLFVSKV-DKVVSAS-----------ERGSILYVGVANVE 306

  Fly   651 AHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRR-TIGRDTRFKY 714
             ::......|:..:|.|.::..:.    |.||.|..::...::.:.|.:..:.. :..|....::
Worm   307 -YKKADAVDRFVALFTKYIMFFEV----TKDMTYDIKEKFTVSGFIVRKKEATEISFDRPNTGEF 366

  Fly   715 QLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTT--CRHC 777
            .|.:....|            |.:::..||.:|             ..:.|.|   |||  .|..
Worm   367 TLTMVSTGG------------EVERFLVALAKA-------------ENVAIIT---PTTTILRRP 403

  Fly   778 SKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPV-----CDRQLSEFNWFAGNMDR 837
            ||.....::|                 |..:..:.|:...||:     .|:|.|..|....:.:.
Worm   404 SKNANDTMNQ-----------------SQTQGAETPLVAKPPLHPPGNSDQQYSMMNKRKSSKNF 451

  Fly   838 ETAAHRLENRRIGTYLLRVRPQG---PSTAHETMYALSLKTDDNV------------------IK 881
            :.:.: |.|.:....|..|.|:|   |:::..     |..|.||:                  .:
Worm   452 DDSLN-LGNMKFDHELGMVLPEGFELPTSSRN-----SRNTADNLQFSQFPSFFLSGNAGKRGDR 510

  Fly   882 HMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPY------------ 934
            ::::.::.:.|..:       .|:|:..|..|......|::....|:|.|.|:
Worm   511 NIRLRKDAARDEEI-------EFETLRILEGYCVETGGGQSDFHANESYQQPHLIVAEDEKILME 568

  Fly   935 ----------KEVIATALYDYEPKAGSNQLQ-LRTDCQVL-----------------------VI 965
                      ::.|..|:|     |..:||. |:|:.|.|                       ||
Worm   569 EMIGDEVVLQEKSIVDAVY-----AIKDQLSFLQTEFQKLAKVVESEQKARRRLEHNLPKMSGVI 628

  Fly   966 GKDGDS 971
            ..||.|
Worm   629 SPDGSS 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	36/184 (20%)
		PH_Vav	624..753	CDD:269930	18/129 (14%)
		PH	641..749	CDD:278594	17/108 (16%)
		C1_1	761..804	CDD:278556	9/44 (20%)
		SH2_Vav_family	824..934	CDD:198193	23/130 (18%)
		SH3	940..993	CDD:302595	14/56 (25%)
pix-1	NP_001257227.1	SH3_PIX	11..62	CDD:212810	10/53 (19%)
		RhoGEF	93..261	CDD:238091	37/177 (21%)
		betaPIX_CC	550..635	CDD:293131	18/90 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910