Protein Alignment Vav and vav-1

DIOPT Version :10

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_001359918.1
• Gene: vav-1 / 181153
• WormBaseID: WBGene00006887
• Length: 1007
• Species: Caenorhabditis elegans
• Alignment Length: 1199
• Identity: 285/1199 - (23%)
• Similarity: 441/1199 - (36%)
• Gaps: 430/1199 - (35%)

  Fly     4 SSSSNSFGGVAGVNG--DLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIH 66
            |||:..|  ...:||  |||..|..||...||:..|......:     .|..||||:|||.|...
 Worm    23 SSSTAVF--KVPMNGGCDLWIGCARWLRDMKVLTTDKNGTMLE-----FASVLRDGILLCRLANT 80

  Fly    67 LDPSSLDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSK 131
            |.|:.:|.::..|..|.:.|||..||..|...|...|.:.|||||....||.:..|.:||.|||.
 Worm    81 LVPNGIDQKKIMRTNQPSPFLCCNNINYFAMFCKTYFNLEDADLFTAEDLYYMNGFQKVLKTLSF 145

  Fly   132 LSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLH---STDLNMRKTSSIDASASSSAEYYD 193
            |                         ||:.|::.:.:.   .||.|...||
 Worm   146 L-------------------------SHTKESLSRGVDPFPDTDNNQEGTS-------------- 171

  Fly   194 RTSQSGSLDENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLLSDCQGSHVRELS 258
                             ||:|..||
 Worm   172 -----------------NGSEFEDD---------------------------------------- 179

  Fly   259 FDLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLL 323
                :::..|..|...| |.|....|     .|:.:|.|.
 Worm   180 ----VEIYQSLHDNIEN-VDPNRTIY-----GPITSADPE------------------------- 209

  Fly   324 VSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNG 388
                                            .:..|::|:.:.
 Worm   210 --------------------------------EQQSEQLYDRIV--------------------- 221

  Fly   389 TGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYL--DVLTALKTKFM 451
                 ||.|......||            .:|...:|:..||||.|||.||:  .::|.:|| |.
 Worm   222 -----TNRKPSMNENDL------------QNTPTLKRNRCIRELYDTEKNYVAQALVTIIKT-FY 268

  Fly   452 GPLERHLNQDELRLIFPRIRELVDIHTKFLDKLR---------ESLTPNAKVKM--------AQV 499
            .||:..:...:..:||..|.|:..:||..|..|.         ...||...:.:        .:|
 Worm   269 EPLKGIIPTSDYNIIFGNIEEINVLHTALLADLEYPVKVALGLSDATPPRPISLNECVPQTIGEV 333

  Fly   500 FLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRIL 564
            |:.:|:.||.||::||.|..:.....::.|.|:.|.:.:.:.....|. |..:.|:|.||.||:.
 Worm   334 FIKYRDQFLAYGKYCSNLPDSRKLSNELLKTNEFISRNINELTAQGNC-KFGMNDLLCVPFQRLT 397

  Fly   565 KYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQN 629
            ||.|||.:|.|:|.....|.:|||.|.|.|.||..||||..||::.:.:|.:::.||.|:.:..|
 Worm   398 KYPLLLKELQKKTDLASPDRKSLEEAVEVMEDVCNYINEESRDTNAIKVIDEIEQSITDLSMPLN 462

  Fly   630 GNGSDLLQYGRLLLDGELHIKAHEDQ-----KTKLRYAFVFDKILIMVKA----LHIKTGDMQ-- 683
               ..|..|||:.||||  :|..|..     |.|.||.|:|||::::.||    :..||....
 Worm   463 ---VKLHDYGRVNLDGE--VKMAESTLTQAGKPKQRYIFLFDKVIVVCKAANKVMAAKTTGASAR 522

  Fly   684 ---YTYRDSHNLADYRVEQS-----HSRRTIGRDTRFKYQLLLARKSGK----TAFTLYLKSEHE 736
               :||::::.:::..::::     .|..||.|  |.:|.:::.|...:    |..|.|.|:|..
 Worm   523 TNTFTYKNAYVMSELTIDKNASLDVKSGGTITR--RTQYVIIMTRDRNENNEITQLTFYFKNEAT 585

  Fly   737 RDKWRKALTEAMESLEPPG-CQSTDHKMEIYTFDA----PTTCRHCSKFLKGRIHQGYRCKVCQI 796
            |:.|..||..:..::.|.. .:.|:||:..::|..    |.||..|.|.:||..:|||:|:.|.:
 Worm   586 RNNWMTALLLSKSNVSPTDYLRDTNHKVAFHSFRVDVKNPATCDVCDKLMKGLQYQGYKCESCNM 650

  Fly   797 SVHKGCI-----------------SSTGRCKQ--------------------------------- 811
            |:||.|:                 |.:..|.:
 Worm   651 SMHKECLGLKKCEAVRKSTHETRSSQSFNCNRPRFHIHEGDIVVANSNSTPSDLSYLQFAKGDRI 715

  Fly   812 -----------------------------------------NPV-----SVPPPV---------- 820
                                                     :|:     |:.|.|
 Worm   716 EVIKMQGHNRFTGCLINNRNRTGLVHLDHVSQSRTTSMIGLSPIDSPAGSIAPRVVRNESTVLPN 780

  Fly   821 -----------------------------------------CDRQLSEFNWFAGNMDRETAAHRL 844
                                                     .:.::|||.|:.|.|:|..|...|
 Worm   781 KLLSDGSSRSLSGPHGSRSSRNSSSSTINGSMDSVPRQQDYVNTEISEFLWYMGEMERAKAESTL 845

  Fly   845 ENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVE 909
            :....||:|:|.......||    .:||.|.|   :|||.|  |.:.|..:| |.....|.:.||
 Worm   846 KGTPNGTFLVRYSKNRKQTA----ISLSYKND---VKHMII--EQNSDGKVY-LDEDYIFNSTVE 900

  Fly   910 LVSYYERNDLGENFAGLNQSLQWPYKEV-IATALYDYEPKAGSNQ---LQLRTDCQVLVIGKDGD 970
            ||.||..|:|.|.||.|:..|:.||.:. :..|::||:..:.:|:   |..:|...|:::...|:
 Worm   901 LVQYYRSNNLIEIFAALDTCLKNPYSQCKVFKAVHDYDAPSPNNEGKFLSFKTGDIVVLLDTVGE 965

  Fly   971 SKGWWRGKIGDTVGYFPKEYVQEQKLASE 999
            .:|||:|::.:..|:||..||:....|:|
 Worm   966 DRGWWKGQVNNKSGFFPLSYVKPYDPATE 994

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH_VAV	19..135	CDD:409050	45/115 (39%)
		RhoGEF	428..602	CDD:459876	64/192 (33%)
		PH_Vav	624..753	CDD:269930	41/151 (27%)
		C1_VAV	759..810	CDD:410360	21/71 (30%)
		SH2_Vav_family	824..934	CDD:198193	41/109 (38%)
		SH3	940..993	CDD:473055	17/55 (31%)
vav-1	NP_001359918.1	CH_VAV	38..149	CDD:409050	46/140 (33%)
		RhoGEF	241..435	CDD:238091	65/195 (33%)
		PH_Vav	453..602	CDD:269930	44/155 (28%)
		C1_VAV	609..662	CDD:410360	20/52 (38%)
		SH2_Vav_family	825..925	CDD:198193	41/109 (38%)
		SH3	927..987	CDD:214620	16/59 (27%)