DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vav and tag-52

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_508633.1	Gene:	tag-52 / 180657	WormBaseID:	WBGene00006431	Length:	665	Species:	Caenorhabditis elegans

Alignment Length:	468	Identity:	100/468 - (21%)
Similarity:	182/468 - (38%)	Gaps:	106/468 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 YVTFQAKAK-------PEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQR 425
            |.|:|:.:.       |:..||..         |:.....:..|:..|:....:         ::
Worm     9 YYTYQSDSSQGSLQKAPDENTDYF---------THKMNSYLPFDMSTLYANQPT---------EK 55

  Fly   426 DYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDE--LRLIFPRIRELVDIHTKFLDKLRESL 488
            ..:::|:.|||..|:..||.:...|:..|.....:.:  .|.:|..|..:...|...|:.|:  .
Worm    56 IQILQEIYDTERTYVKALTIVDEIFIQQLNLWCPKSKKCFRSMFGEISAICKTHQILLESLQ--C 118

  Fly   489 TPNAKVKMAQVFLDFREPFL-IYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQL 552
            .|     :|:||..| .||| :|..:.|....::...|.:..:|.....|. |.|.|..|...:|
Worm   119 KP-----IAEVFTKF-VPFLKLYTSYASHYPNSLKIFAKLMSRNDFRKALT-KIEEDPRVDGKKL 176

  Fly   553 RDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINE---VKRDSDHLVII 614
            :..|.:|:|||.:|.:|:..|:..::. .||..:|.:|...|..:|..|..   ...:.:.|:.|
Worm   177 QTYLIMPIQRIPRYIMLIQNLMNYSTE-KDDMTNLYKALSGMQGLSDQIQSCMTAYENGERLLQI 240

  Fly   615 QKVKDSICDIHLLQNGNGSDLLQYGRLLL-DGELHIK----AHEDQKTKLRYAFVFDKILIM-VK 673
            |           |..|....:|:.||:|| :|.|:.:    :...|:|   ..|:|:.||:. :|
Worm   241 Q-----------LNFGLDGHILEPGRVLLKEGMLYKRELNGSANYQET---VVFLFNDILLYGIK 291

  Fly   674 ------------------------------ALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGR 708
                                          ::.|:.||:...: .:::|..  |.:.::......
Worm   292 RISVMPLCKYEPSAILSLRHCIVQLDDIGGSIFIRCGDVGVDF-TAYSLGG--VTEWYNEICDAI 353

  Fly   709 DTRFKYQLLLARKSGKTAFTLYLKS--EHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAP 771
            |...|.:..|.::|.|....::.|.  :..|||.|..:|..|          |.:...:.|...|
Worm   354 DNAKKLRDTLRKESFKQKSLIFDKGFWQRNRDKLRNMITADM----------TGNISRVLTRKKP 408

  Fly   772 TTCRHCSKFLKGR 784
            ......|.||:|:
Worm   409 APKLEESDFLRGQ 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	48/177 (27%)
		PH_Vav	624..753	CDD:269930	33/166 (20%)
		PH	641..749	CDD:278594	27/145 (19%)
		C1_1	761..804	CDD:278556	6/24 (25%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
tag-52	NP_508633.1	RhoGEF	58..224	CDD:279015	47/175 (27%)
tag-52	NP_508633.1	PH-like	232..>318	CDD:302622	19/99 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910