DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and cgef-1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_741736.2	Gene:	cgef-1 / 180571	WormBaseID:	WBGene00006496	Length:	1055	Species:	Caenorhabditis elegans

Alignment Length:	832	Identity:	159/832 - (19%)
Similarity:	290/832 - (34%)	Gaps:	246/832 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DAEIRILAM--------------TLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIKL 94
            |:..|||.:              .:|.|..|...|          |:.::||...|
Worm   310 DSTARILELQTAEKMAIKEEFKIAVRKGFTLLKSV----------RQLDKKPTPEQ--------- 355

  Fly    95 FLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLS---------------KLSQCRKVQQLHPD 144
                            ..||.|:::|...|:|:.|.               :|..|.:::|
Worm   356 ----------------LSPTRLHNVTAIERMLVQLEETERSFDSFWTKHERRLRYCLELRQ---- 400

  Fly   145 LIGFNLQLSPTERSHSDEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDRTSQSGSLDE-NSDIT 208
               |.......:.:.:...:|.:.|      |:..:....|...||.: |....|:::| .:...
Worm   401 ---FEDSFRKLQAAFARHMLYLEEH------REVGNCTEKALHLAEQH-RQYAEGAMEEVEASRN 455

  Fly   209 IENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLL---SDCQGSHVRELSFDLALDVVSS-- 268
            ::...||:.:..|..||...:...:.....|...|..|   .||.   .|..:....:...:|
Worm   456 LKKAGEDLINSNEAELSGSLEPKCEELERMAAALTSALERRGDCL---KRSATMHEQIAKANSWC 517

  Fly   269 ------TTDGASNAVTPTPES------------------YARQSQSPLAAAAPSVPVSAAPGPPM 309
                  .|:|.::...|.|.|                  :.:.:.||:...
Worm   518 TRGADLLTNGMTDFTNPNPSSSLTTLDAFIEEGTNLNIEFLKDTTSPMNQL-------------- 568

  Fly   310 GRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQAK 374
              |:.|:..:|:||....:|:....      |.|:|..: :...::.:....|.    .||.:.|
Worm   569 --LLLTTIETSTLLNLIEERIGDIR------RMSLAKRD-QLTKLHLQKPPPVQ----VVTPEKK 620

  Fly   375 AKPEVTTDNI------ACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELI 433
            :|...:.:.:      :|:|          |.......:..|.:|..|   .:|:       |:|
Worm   621 SKKNSSKNELDSKDVPSCSG----------ESTPAGTLSPRRETREVT---NAFD-------EMI 665

  Fly   434 DTESNYLDVLTALKTKFMGPLERHLNQ----DELR----LIFPRIRELVDIHTKFLDKLRESLTP 490
            .||.:|:..|..:...::.|.|...||    |.||    .:|..:|||...|.:.:  |.:.:..
Worm   666 ATEISYVADLKDIIIHYLEPFEATENQNSLPDTLRGKPDCLFGNVRELYKFHHRTV--LEDLVAA 728

  Fly   491 NAKVKMAQVFLDFR-EPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRD 554
            .:..:|.:|.:..| :.::.|..:|. :.|:...:.|..|.:...    ::|:|:.| ..:.:..
Worm   729 RSTAEMCRVLMQHRNQIYVTYRTYCQ-IHGSNQKVRDSVKNHPFF----KECQRNAN-HNMDMSS 787

  Fly   555 ILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKD 619
            .|..|:|||:||.|||..::       ||..:..|.:.||          .||| .:.::.::..
Worm   788 YLLKPIQRIMKYQLLLGNIM-------DDCPADVRDEVAM----------TRDS-MVELLNQIDA 834

  Fly   620 SICDIHLLQNGNGSDLLQYGRLLLDGELHIKAH-EDQKTKL-----RYAFVFD------------ 666
            |:..:|:  :|...||...|.|.|..|..:..: ..:|.||     |:.|.||
Worm   835 SMQQLHI--SGYNGDLKSLGLLRLQTECDVFTYNRKKKAKLSRAQKRFIFFFDGAVMFCKKRVSN 897

  Fly   667 --------------KILIMVKAL----HIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFK 713
                          |..|.:.:|    ..:||..::...|......|.:|      ||.:..|.|
Worm   898 PGTTLNSEPEYFEHKFCIPIISLGYDTSSRTGASRFEVWDDAKTDAYVIE------TIDQTARTK 956

  Fly   714 YQLLLARKSGKTAFTLYLKSEHERDKWRKALT-EAMESLEPPGCQSTDHKME 764
            :...|.:  .:||....|::......|...:: |:..|.......|||..|:
Worm   957 WIQRLGK--SETAQDACLENRQRPKSWASTVSNESSCSSSTRESDSTDSTMD 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723	19/116 (16%)
		RhoGEF	428..603	CDD:279015	45/183 (25%)
		PH_Vav	624..753	CDD:269930	34/165 (21%)
		PH	641..749	CDD:278594	28/144 (19%)
		C1_1	761..804	CDD:278556	1/4 (25%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
cgef-1	NP_741736.2	CRAL_TRIO_2	141..269	CDD:372686
		RhoGEF	658..833	CDD:238091	50/210 (24%)
		PH-like	841..968	CDD:388408	28/136 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910