DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vav and dkf-2

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001256725.1	Gene:	dkf-2 / 180121	WormBaseID:	WBGene00012019	Length:	1095	Species:	Caenorhabditis elegans

Alignment Length:	849	Identity:	161/849 - (18%)
Similarity:	271/849 - (31%)	Gaps:	281/849 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 TTDGASNAVTPT-----PESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQ 328
            ||...|.:.:|:     .|::.|.|.|.||..                  :.|.|..|..:.|:.
Worm    23 TTTRFSTSFSPSIPCHRQENFRRHSTSALAKR------------------NGSESEKSAEIRENP 69

  Fly   329 RLQRAAAAVYNYRSSMA--STEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGY 391
            . :...:.|....||:|  :|.||.:.:.|.|..
Worm    70 D-EIEVSRVSGRDSSLAFYTTAHETSSMLSRDSR------------------------------- 102

  Fly   392 DHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLER 456
            |.|.|..|.::|      .:||..:|:.:.||. .||  :.:|....:    .:.:..|....:|
Worm   103 DETLTPNEHIHQ------ASSRRVSANDSVFED-GYV--DFVDEPREH----GSRRKSFEKFTDR 154

  Fly   457 HLNQDELRLIF------PRIRELVDIHTKFLDKLRESLTPNAKVKMA--QVFLDFR-EPFLIYGE 512
            :..:.|.| :|      |........|...|..|..:.||......:  :|:..:| .|...|..
Worm   155 NGEEKEGR-VFELSTPQPTREAAPGAHQFQLPTLLVTSTPTTVFDHSDDEVWTPYRPPPNREYSS 218

  Fly   513 FCSLLLGAIDY--LADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVK 575
            ....::|.:.:  .:.:.||:..::..           ::.|||:.:..:|           .:|
Worm   219 SSEPMMGDLTFRLQSGIHKKSIAVEGT-----------EIALRDLRNEALQ-----------FIK 261

  Fly   576 ETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDS--ICDIHLLQNGNGSDLLQY 638
            |..|        |:...::.|   ||...|.|...:.|:|.:..|  :.|..|::...|| ..|.
Worm   262 EIYP--------EKGCSSLED---YILLYKHDLRSINILQLITTSSDVTDGTLVEVVIGS-CPQN 314

  Fly   639 GRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVK-ALHIKTGDMQYTYR--------------- 687
            .|:::  ..|.......|......|..:.:..:|| .|......:.|..|
Worm   315 ERIVV--HPHTLFVHSYKVPTFCDFCGELLFGLVKQGLKCFGCGLNYHKRCASKIPNNCNGSKQR 377

  Fly   688 ---------DSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTL-------------- 729
                     .:.|:.:.. |:.||||.         ..|.|..:.:.:.||
Worm   378 RPSAIPLSPSNSNILNLN-ERRHSRRE---------SCLEALDAARPSSTLGGAATPNIFITSDD 432

  Fly   730 --------YLKSEHE--------RDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCS 778
                    ||:...:        |..|.:........|:.|      |..:::::..||.|:||.
Worm   433 CGDAVGGNYLQMPRKDRSCSWSGRPLWMEIAEATRVKLQVP------HTFQVHSYKLPTVCQHCK 491

  Fly   779 KFLKGRIHQGYRCKVCQISVHKGCISSTGR-CKQNPVSVPPPVCDRQLSEFNWFAGNMDR----- 837
            |.|||.|.||.:|:.|:.:.||.|.....: |..| ..........|..:.....|:||.
Worm   492 KLLKGLIRQGMQCRDCKYNCHKKCSEHVAKDCSGN-TKASQFFLGSQADDGTSLTGSMDNLRMCS 555

  Fly   838 ------ETAAHRLENR------RIGTYLLRVRPQGPSTAHE--------------TMYALSLKTD 876
                  ::.:...|:|      |.|:...:.....||...:              ...|||...|
Worm   556 VPFGSDQSTSGASEDRDDDLSLRSGSGAHKKAQNTPSAPLQGSEGSGSPGPVVSFAANALSNMPD 620

  Fly   877 DNVIKHMKINQENSGDSMLYCLSSRRHFKT----------IVELVS------------------- 912
            |:|     |:.|::...::..:.|::..|.          ||....
Worm   621 DDV-----ISSESANIPLMRVVMSKKQTKRKNNKLLKEGWIVHYTDQQNMRKKHYWRLDTKGITM 680

  Fly   913 --------YYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQVLVIGKDG 969
                    ||:...|.|.   ||.|:..|.|    ||.|.:|.:.|.        |...:.|...
Worm   681 YQDENTTRYYKEIPLNEI---LNVSMSPPDK----TADYLFEIRTGV--------CVYFISGSPS 730

  Fly   970 DSKG 973
            |.||
Worm   731 DEKG 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	31/185 (17%)
		PH_Vav	624..753	CDD:269930	28/183 (15%)
		PH	641..749	CDD:278594	22/162 (14%)
		C1_1	761..804	CDD:278556	18/42 (43%)
		SH2_Vav_family	824..934	CDD:198193	29/177 (16%)
		SH3	940..993	CDD:302595	10/34 (29%)
dkf-2	NP_001256725.1	C1_1	326..371	CDD:278556	7/44 (16%)
		C1	474..523	CDD:237996	18/48 (38%)
		PH_PKD	643..753	CDD:269945	22/107 (21%)
		STKc_PKD	791..1050	CDD:270984
		Pkinase	798..1051	CDD:278497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910