DRSC/TRiP Functional Genomics Resources

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Protein Alignment Vav and dkf-2

DIOPT Version :9

Sequence 1:NP_001097030.1 Gene:Vav / 32920 FlyBaseID:FBgn0040068 Length:1001 Species:Drosophila melanogaster
Sequence 2:NP_001256725.1 Gene:dkf-2 / 180121 WormBaseID:WBGene00012019 Length:1095 Species:Caenorhabditis elegans


Alignment Length:849 Identity:161/849 - (18%)
Similarity:271/849 - (31%) Gaps:281/849 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 TTDGASNAVTPT-----PESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSSSSSLLVSESQ 328
            ||...|.:.:|:     .|::.|.|.|.||..                  :.|.|..|..:.|:.
 Worm    23 TTTRFSTSFSPSIPCHRQENFRRHSTSALAKR------------------NGSESEKSAEIRENP 69

  Fly   329 RLQRAAAAVYNYRSSMA--STEHEYAYIYSEDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGY 391
            . :...:.|....||:|  :|.||.:.:.|.|..                               
 Worm    70 D-EIEVSRVSGRDSSLAFYTTAHETSSMLSRDSR------------------------------- 102

  Fly   392 DHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLER 456
            |.|.|..|.::|      .:||..:|:.:.||. .||  :.:|....:    .:.:..|....:|
 Worm   103 DETLTPNEHIHQ------ASSRRVSANDSVFED-GYV--DFVDEPREH----GSRRKSFEKFTDR 154

  Fly   457 HLNQDELRLIF------PRIRELVDIHTKFLDKLRESLTPNAKVKMA--QVFLDFR-EPFLIYGE 512
            :..:.|.| :|      |........|...|..|..:.||......:  :|:..:| .|...|..
 Worm   155 NGEEKEGR-VFELSTPQPTREAAPGAHQFQLPTLLVTSTPTTVFDHSDDEVWTPYRPPPNREYSS 218

  Fly   513 FCSLLLGAIDY--LADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVK 575
            ....::|.:.:  .:.:.||:..::..           ::.|||:.:..:|           .:|
 Worm   219 SSEPMMGDLTFRLQSGIHKKSIAVEGT-----------EIALRDLRNEALQ-----------FIK 261

  Fly   576 ETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDS--ICDIHLLQNGNGSDLLQY 638
            |..|        |:...::.|   ||...|.|...:.|:|.:..|  :.|..|::...|| ..|.
 Worm   262 EIYP--------EKGCSSLED---YILLYKHDLRSINILQLITTSSDVTDGTLVEVVIGS-CPQN 314

  Fly   639 GRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVK-ALHIKTGDMQYTYR--------------- 687
            .|:::  ..|.......|......|..:.:..:|| .|......:.|..|               
 Worm   315 ERIVV--HPHTLFVHSYKVPTFCDFCGELLFGLVKQGLKCFGCGLNYHKRCASKIPNNCNGSKQR 377

  Fly   688 ---------DSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTL-------------- 729
                     .:.|:.:.. |:.||||.         ..|.|..:.:.:.||              
 Worm   378 RPSAIPLSPSNSNILNLN-ERRHSRRE---------SCLEALDAARPSSTLGGAATPNIFITSDD 432

  Fly   730 --------YLKSEHE--------RDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCS 778
                    ||:...:        |..|.:........|:.|      |..:::::..||.|:||.
 Worm   433 CGDAVGGNYLQMPRKDRSCSWSGRPLWMEIAEATRVKLQVP------HTFQVHSYKLPTVCQHCK 491

  Fly   779 KFLKGRIHQGYRCKVCQISVHKGCISSTGR-CKQNPVSVPPPVCDRQLSEFNWFAGNMDR----- 837
            |.|||.|.||.:|:.|:.:.||.|.....: |..| ..........|..:.....|:||.     
 Worm   492 KLLKGLIRQGMQCRDCKYNCHKKCSEHVAKDCSGN-TKASQFFLGSQADDGTSLTGSMDNLRMCS 555

  Fly   838 ------ETAAHRLENR------RIGTYLLRVRPQGPSTAHE--------------TMYALSLKTD 876
                  ::.:...|:|      |.|:...:.....||...:              ...|||...|
 Worm   556 VPFGSDQSTSGASEDRDDDLSLRSGSGAHKKAQNTPSAPLQGSEGSGSPGPVVSFAANALSNMPD 620

  Fly   877 DNVIKHMKINQENSGDSMLYCLSSRRHFKT----------IVELVS------------------- 912
            |:|     |:.|::...::..:.|::..|.          ||....                   
 Worm   621 DDV-----ISSESANIPLMRVVMSKKQTKRKNNKLLKEGWIVHYTDQQNMRKKHYWRLDTKGITM 680

  Fly   913 --------YYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQVLVIGKDG 969
                    ||:...|.|.   ||.|:..|.|    ||.|.:|.:.|.        |...:.|...
 Worm   681 YQDENTTRYYKEIPLNEI---LNVSMSPPDK----TADYLFEIRTGV--------CVYFISGSPS 730

  Fly   970 DSKG 973
            |.||
 Worm   731 DEKG 734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
VavNP_001097030.1 CH 20..132 CDD:278723
RhoGEF 428..603 CDD:279015 31/185 (17%)
PH_Vav 624..753 CDD:269930 28/183 (15%)
PH 641..749 CDD:278594 22/162 (14%)
C1_1 761..804 CDD:278556 18/42 (43%)
SH2_Vav_family 824..934 CDD:198193 29/177 (16%)
SH3 940..993 CDD:302595 10/34 (29%)
dkf-2NP_001256725.1 C1_1 326..371 CDD:278556 7/44 (16%)
C1 474..523 CDD:237996 18/48 (38%)
PH_PKD 643..753 CDD:269945 22/107 (21%)
STKc_PKD 791..1050 CDD:270984
Pkinase 798..1051 CDD:278497
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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