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Protein Alignment Vav and uig-1

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001256489.1	Gene:	uig-1 / 179808	WormBaseID:	WBGene00009337	Length:	972	Species:	Caenorhabditis elegans

Alignment Length:	906	Identity:	185/906 - (20%)
Similarity:	334/906 - (36%)	Gaps:	251/906 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 KLSQCRKVQQLHPDLIGFNLQLSPTERSHS-DEAIYKDLHSTDLNMRKTSSIDASASSSAEYYDR 194
            :.|:|....:....|.|:..:    :|.|. |..:.:.:.|..: .|..|.:|.|.
Worm    20 QFSECANDDEPTVQLQGYRQR----DREHEVDPRMTQSMISERI-QRSQSPVDVSL--------- 70

  Fly   195 TSQSGSLDENSDITIENGTEDIDDYIEDSLSNMCDSTIDNDAEDAGVETPLL--SDCQGSHVREL 257
                 :|.|:|.|||   ||         |:|...||.:.::.:|   ||::  ...|.|.||:.
Worm    71 -----ALSEDSTITI---TE---------LNNRNGSTFNANSINA---TPVMRRRRSQMSGVRQR 115

  Fly   258 SFDLALDVVSSTTDGASNAVTPTPESYARQSQSPLAAAAPSVPVSAAPGPPMGRLVSTSSS---- 318
            ::.: ||...|              .|..|.||           :||.....|.|:...||
Worm   116 NYRI-LDQNES--------------KYILQQQS-----------AAAIEEKKGTLLRRKSSKKLI 154

  Fly   319 -------SSSLLVSESQRLQRAAAAVYNYRS---SMASTEHEYAYIYSEDDEKVYEDLCYVTFQA 373
                   :..:|::.:|    ..|..|..:|   |::|....|.          .|.:..||...
Worm   155 EPLPMIITPPVLMARTQ----CCAVCYKEKSTGYSVSSRTQSYP----------LEAMSSVTTDR 205

  Fly   374 KAKPEVTTDNIACNGTGY-------------DHTNT----KEEEVYQDLCALHRTS---RSQTAS 418
            ..:.|....:...:.|||             |.:|.    ..:....:..:|...|   ||...:
Worm   206 STEEETARLSFVSSSTGYSSARSSLRSSDGGDESNNNSAGNRDSAISNTFSLSSQSSARRSALLT 270

  Fly   419 STSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPL-----ERHLNQDELRLIFPRIRELVDIHT 478
            ..|....|.:..||:|||..|::.|.|:...:|..|     :..:..|.:..:|..|..:...:.
Worm   271 KGSLTHLDRIAIELLDTERTYVEDLNAVIKGYMDFLVEDREKLKVTLDAISSLFGCIERIFAFNK 335

  Fly   479 KFLDKLRESLTPNAK----VKMAQVFLDFREPFLIYGEFCS---LLLGAIDYLADVCKKNQIIDQ 536
            :..::|      :|.    |||::.|::....|..|.|:|:   .::..:.:|    ::..::.:
Worm   336 QLYNQL------DAADLDCVKMSRCFVESSGKFEDYIEYCTNYHRMMSTLYHL----QQQPLVAR 390

  Fly   537 LVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKE-TSPLH-DDYRSLERAKEAMIDVSQ 599
            .:|:.:...| ..|||...|..|:||||||||.|:.::|. .|..| ::...::||.|.|...:.
Worm   391 ALQERQLALN-HSLQLSAYLLKPVQRILKYHLFLENILKNMPSTTHPEELIQVKRAHEVMTSQAA 454

  Fly   600 YINEVKRDSDHLVIIQKVKDSICDIHLLQNGNG-----SDLLQYGRLLLDGELHIKAHEDQKTKL 659
            .||:.|:.::|:..:.:::.:      ||....     |:|..||.|||:....   ....|| .
Worm   455 RINDEKKKAEHIERVGQLQST------LQKWKADEIQISNLSAYGDLLLEATFR---QAGSKT-T 509

  Fly   660 RYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGK 724
            |..|:|:::|::||    :.| ..|..:|....::..:.:     .|..:....:| :|:..:.:
Worm   510 RLLFLFEEMLLIVK----QRG-ANYVCKDYIMCSNLMLNE-----WICPEEPLSFQ-VLSFDNPR 563

  Fly   725 TAFTLYLKSEHERDKWRKALTEAM---ESLEPPGCQSTDHKM------EIYTFDAPTTC------ 774
            ..:.....|..::..|.:.|...|   .|:|.|  :.|...|      .|..|..|...
Worm   564 AQYVFMASSMEQKRTWMQELKRMMLDHYSVEIP--EKTKQLMLSIDNTRIVPFGRPEFAEVSMKN 626

  Fly   775 -RHCSKFLKGR--------------------------------IHQGYRCKVCQIS--VHKGCIS 804
             :...|:|:.|                                |.:..:| .|.::  ::.|...
Worm   627 HKKVPKYLEKRRKSVDAKEESNRRRSLSASRLLGGSKTSISEPIKEEQKC-TCHMNGGIYNGANP 690

  Fly   805 STGRC----------------KQNPVSVPPPVCDRQ-----------LSEFNWFAGNMDRETAAH 842
            :|.:.                ..:|....||||..|           ::|.| .|..|...:...
Worm   691 TTSKSIISHPSLTYQQSHPTQSTDPNYCRPPVCRTQSAATIDLNQVHITEPN-SAAVMSSRSRYQ 754

  Fly   843 RLENRRIGTYLLRVRPQGPSTAHETMYALSL-KTDDNVIKHMKINQENSGDSMLYCLSSRR 902
            :..|||:..   |...:..||:...|....: :|.|.:.:.:    .:.|||....::|.|
Worm   755 QARNRRLPP---RHNQESRSTSSRRMGEEEIDRTFDQLYEEL----VSFGDSTKPTVTSNR 808

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.