Protein Alignment Vav and rhgf-2

DIOPT Version :9

• Sequence 1: NP_001097030.1
• Gene: Vav / 32920
• FlyBaseID: FBgn0040068
• Length: 1001
• Species: Drosophila melanogaster
• Sequence 2: NP_001368191.1
• Gene: rhgf-2 / 173748
• WormBaseID: WBGene00006476
• Length: 1149
• Species: Caenorhabditis elegans
• Alignment Length: 754
• Identity: 142/754 - (18%)
• Similarity: 265/754 - (35%)
• Gaps: 216/754 - (28%)

  Fly   214 EDIDDYIEDSLSNM---CDSTIDNDAEDAGVETPLLSDCQGSHVRELSFDLALDVVSSTTDGASN 275
            :|:||..:||:.::   |:..|..      |..|.|. .:|..:.::.|.|            ..
 Worm   193 KDLDDREKDSVEHIRFDCNQLIYE------VFEPFLR-IRGLTINDVEFFL------------EK 238

  Fly   276 AVTPTPES-----------------------YARQSQS----------PLAAAAPSVPVSAA--- 304
            :.||.||:                       :.|.:.|          .::|.|.|...|..
 Worm   239 SSTPIPENSGARFLAGQRIFVRGRGNMKVVRHTRATHSMDESNERATRKMSAEAVSRKSSFVNSR 303

  Fly   305 ---------PGPPMGRLVSTSSSSSSLLVSESQRLQRAAAAVY----NYRSSMASTEHEYAYIYS 356
                     ||..........|:.|||.|.:|.:....:.:..    ..|.:.:.|....:..:.
 Worm   304 ILNRGSRNHPGLNGSDDAECRSNDSSLSVRDSWQYDEPSCSEVPDDGGTRRARSVTSSRISLFFG 368

  Fly   357 EDDEKVYEDLCYVTFQAKAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTS 421
            ::..|:.:::..:..|.|            ..|..::...|.|:.::::...|     ::.|..|
 Worm   369 KETGKIEKEMFRILNQKK------------EDTDLEYPTYKLEKDWREIVHNH-----ESLSDKS 416

  Fly   422 FEQRDYVIRELIDTESNYLDVLTALK--TKFMGPLER--HLNQDELRLIFPRIRELVDIH----- 477
            .:|:: .|.|::.||..|:.:|..|.  :.::..|:.  .|...|.||:|.....|.:::
 Worm   417 IKQQE-AIWEIVTTEFRYIKLLRYLSNLSFYLTDLQNCGFLKDIENRLVFFNFVTLFNVNYDSLW 480

  Fly   478 ----TKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLV 538
                ...|.|.||:..|.....:...|.|.......|..|......::.::....|:::.....|
 Worm   481 LQSIEPILAKSRETGEPLDVNYLQNGFRDIENWSRCYTNFHLAHSDSLKHIQKKLKESENFRDFV 545

  Fly   539 QKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSL-----ERAKEAMIDVS 598
            ...|...|:.:.:|.|..||||||:.:|:|||..::|.|:  .::.|.:     :.|:.|...::
 Worm   546 TWAEAQENLDRQKLIDTFSVPMQRLTRYNLLLKAVLKVTT--DENEREMISNLVDCAESATAQLN 608

  Fly   599 QYIN---------EVKR--------DSDHLVIIQKVKDSICDIHL-LQNGNGSDLLQ-----YGR 640
            :.:|         :|.|        |.|.|       :.:.::.| |..|:...||.     :..
 Worm   609 KELNNNDLRAMLGDVMRTIEGPDYVDQDEL-------ERLFNLKLPLNLGDFMPLLHPRKPTHRT 666

  Fly   641 LLLDGELHIKAHEDQKTKLRYAFVF--------------DKILIMVKALHIKTGDMQYTYRDSHN 691
            |:..|:|.::..:.......:..:|              |::.|:...:|:  |.|.:.|....|
 Worm   667 LIYRGDLRMQEGKKGSKADVHCIIFTDMFLICRKVQGKKDRLKILKPPIHM--GKMMFHYFADQN 729

  Fly   692 ------LADYRVEQS-HSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKW--------- 740
                  |.|:...|: :|..|.|.:...::..:|     |.|...:.|.  .||.|
 Worm   730 GFYLVHLTDFHTAQALYSMHTSGPEDTLRWTDML-----KMALDEFKKI--HRDSWSQQNQQESP 787

  Fly   741 -----RKALTEA----MESLEPPG------------CQSTD--------HKMEIYTFDAPTTCRH 776
                 |..:.|.    .:.:.|||            |.|.|        |...::...|.::...
 Worm   788 LDEYGRGFIMEPSSFYSQRMLPPGYAQQQMPVIHRKCSSMDSQAVAAHAHLNYMHRSSAVSSTEQ 852

  Fly   777 CSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVS 815
            ..:      |.|.....|....||..::|   |..||:|
 Worm   853 LDR------HSGTDSMKCSPPRHKLSVAS---CHANPLS 882

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vav	NP_001097030.1	CH	20..132	CDD:278723
		RhoGEF	428..603	CDD:279015	45/201 (22%)
		PH_Vav	624..753	CDD:269930	31/173 (18%)
		PH	641..749	CDD:278594	26/146 (18%)
		C1_1	761..804	CDD:278556	7/42 (17%)
		SH2_Vav_family	824..934	CDD:198193
		SH3	940..993	CDD:302595
rhgf-2	NP_001368191.1	RBD_PLEKHG5	186..262	CDD:340588	17/87 (20%)
		RhoGEF	419..608	CDD:238091	45/191 (24%)
		PH_PLEKHG5_G6	665..765	CDD:270064	18/106 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910