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Protein Alignment Vav and Mcf2l

DIOPT Version :9

Sequence 1:	NP_001097030.1	Gene:	Vav / 32920	FlyBaseID:	FBgn0040068	Length:	1001	Species:	Drosophila melanogaster
Sequence 2:	NP_001357978.1	Gene:	Mcf2l / 17207	MGIID:	103263	Length:	1178	Species:	Mus musculus

Alignment Length:	1000	Identity:	199/1000 - (19%)
Similarity:	351/1000 - (35%)	Gaps:	328/1000 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 KLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHST-DLNMRKTSSIDASASSSAEYYDR 194
            ||.||              |||...|:.      ::::.:| |...:|.::.....:|.|.....
Mouse   316 KLEQC--------------LQLRHFEQG------FREVKTTLDSMSQKIAAFTDVGNSLAHVQHL 360

  Fly   195 TSQSGSLDENSDITIE-------NGTEDIDD--YIEDS-------LSNMCDSTIDNDAEDAG--- 240
            .....:.:|.|.:.::       .|.:.|::  |..||       |.::||..........|
Mouse   361 LKDLTAFEEKSSVAVDKARALSLEGQQLIENRHYAVDSIHPKCEELQHLCDHFASEVTRRRGLLS 425

  Fly   241 --------VETPL--------------LSDCQGSHVRELSFDLALDVVSSTTDGASNAVTPTPES 283
                    :||.:              :..||.....|.:..   ::......||.|.:....|.
Mouse   426 KSLELHSLLETSMKWSDEGIFLLASQPVDKCQSQDGAEAALQ---EIEKFLETGAENKIQELNEI 487

  Fly   284 Y------------------------------ARQSQSPLAAAAPSVPV----------SAAPGPP 308
            |                              .||:.....||..:.||          :.:|.|.
Mouse   488 YKEYECILNQDLLEHVQKVFQKQESTEEMFHRRQASLKKLAAKQTRPVQPVAPRPEALTKSPSPS 552

  Fly   309 MGRLVSTSSSSSSLLVSESQRLQRAAAAVYNYRSSMASTEHEYAYIYSEDDEKVYEDLCYVTFQA 373
            .|...|:.:||     ||...|:|..     ||
Mouse   553 PGSWRSSENSS-----SEGNALRRGP-----YR-------------------------------- 575

  Fly   374 KAKPEVTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESN 438
            :||.|::.......      ::|.|||  :.|..|.|                :|:.||:|||..
Mouse   576 RAKSEMSEPRQGRT------SSTGEEE--ESLAILRR----------------HVMNELLDTERA 616

  Fly   439 YLD----VLTALKTKFMGPLERHL----NQDELRLIFPRIRELVDIHTK-FLDKLRESLTPNAKV 494
            |::    ||.....:...||..||    .|::..::|..:.|:...|.: ||.:|...:  :...
Mouse   617 YVEELLCVLEGYAAEMDNPLMAHLISTGLQNKKNILFGNMEEIYHFHNRIFLRELESCI--DCPE 679

  Fly   495 KMAQVFLDFREPFLIYGEFC-------SLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQL 552
            .:.:.||:..|.|.||.::|       ||.....|     |       ...|:|::..: .||.|
Mouse   680 LVGRCFLERMEEFQIYEKYCQNKPRSESLWRQCSD-----C-------PFFQECQKKLD-HKLSL 731

  Fly   553 RDILSVPMQRILKYHLLLDKLVKETSPLH-DDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQK 616
            ...|..|:|||.||.|||.:::|.:.  | :....|:.|..:::.:.:.:|    ||.||:.|..
Mouse   732 DSYLLKPVQRITKYQLLLKEMLKYSK--HCEGAEDLQEALSSILGILKAVN----DSMHLIAITG 790

  Fly   617 VKDSICDIHLLQNGNGSDLLQYGRLLLDGEL-----HIKAHEDQKTKLRY------AFVFDKILI 670
                       .:||..||   |:||:.|..     |.|.|...|...|:      .|:.:|.::
Mouse   791 -----------YDGNLGDL---GKLLMQGSFSVWTDHKKGHTKVKELARFKPMQRHLFLHEKAVL 841

  Fly   671 MVKALHIKTGD-----MQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLL-ARKSGKTAFTL 729
            ..|... :.|:     ..|:|:.|.|:....:.::     :..||: |:::.. ||:.   .:.:
Mouse   842 FCKKRE-ENGEGYEKAPSYSYKQSLNMTAVGITEN-----VKGDTK-KFEIWYNAREE---VYII 896

  Fly   730 YLKSEHERDKW----RKALTEAMESLEPPGCQSTDHKM--EIYTFDAPT---------TCRHCSK 779
            ...:...:..|    ||.||..:::..    :::.|:.  :.::...||         ..|:..|
Mouse   897 QAPTPEIKAAWVNEIRKVLTSQLQACR----EASQHRALEQSHSLPLPTPSSTSPTKGNTRNVKK 957

  Fly   780 FLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRL 844
             |:.|       |...:|: :|.:||         |:|.|   .:..:.:....:....:|..|.
Mouse   958 -LEDR-------KTDPLSL-EGYVSS---------SLPKP---PEKGKDDAVPSSTSESSALSRK 1001

  Fly   845 ENRRIGTYLLRVRPQGP---STAHE-----TMYALS--LKTDDNVIKHMKINQENSGDSMLYCLS 899
            .....|...|:..|..|   :..||     |.:.|.  .||..:    ::..:|:.|
Mouse  1002 RFTLQGLANLKASPTSPDKKAKRHEVKSDPTPFGLRGWSKTSHS----LEAPEEDGG-------- 1054

  Fly   900 SRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQVLV 964
                :.:..||::..:..:.|    |:......|.|   .|.:.|.| |.|.:.|.:|:...|.|
Mouse  1055 ----WSSAEELINSSDAEEDG----GVGPKKLVPGK---YTVVMDDE-KGGPDTLAMRSGDMVEV 1107

  Fly   965 IGKDGDSKGWW--RGKIGDTVGYFP 987
            : ::| ::|.|  |.......|:.|
Mouse  1108 V-EEG-AEGLWYVRDLTSSKEGWVP 1130

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.